Caveolae Intracellulares and Sarcoplasmic Reticulum in Smooth Muscle

1971 ◽  
Vol 8 (3) ◽  
pp. 601-609
Author(s):  
G. GABELLA
Keyword(s):  
Skeletal Muscle ◽  
Smooth Muscle ◽  
Plasma Membrane ◽  
Sarcoplasmic Reticulum ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Guinea Pig Ileum ◽  
Intracellular Store ◽  
Similar Role ◽  
Close Relationship

In the smooth-muscle cells from guinea-pig ileum a highly developed sarcoplasmic reticulum has been observed immediately underneath the plasma membrane in close relationship to the caveolae intracellulares. It is suggested that sarcoplasmic reticulum in smooth muscle may play a similar role as in skeletal muscle, constituting the main intracellular store for calcium.

scholarly journals Changes in Ca2+ Signaling and Contractile Protein Isoforms in Smooth Muscle Cells from Guinea Pig Ileum during Culture.

2001 ◽  
Vol 37 (2) ◽  
pp. 53-66 ◽  
Author(s):  
Michiko Iijima ◽  
Junko Yamamoto ◽  
Noriko Takada ◽  
Hisayuki Ohata ◽  
Kazutaka Momose
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Protein Isoforms ◽  
Contractile Protein ◽  
Guinea Pig Ileum

scholarly journals Nexuses between the smooth muscle cells of the guinea-pig ileum.

1979 ◽  
Vol 82 (1) ◽  
pp. 239-247 ◽  
Author(s):  
G Gabella ◽  
D Blundell
Keyword(s):  
Smooth Muscle ◽  
Cell Surface ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cell ◽  
Packing Density ◽  
Freeze Fracture ◽  
Muscle Cells ◽  
Guinea Pig Ileum ◽  
Average Cell

The circular musculature of the guinea-pig ileum has been studied by freeze-fracture to analyze quantitatively the gap junctions (nexuses) between its smooth muscle cells. The average cell surface area and cell volume are 5,074 micron 2 and 3,260 micron 3. The packing density of nexuses is 48/1,000 micron 2 of cell surface or approximately 244/muscle cell. Nexuses range in area from less than 0.1 to approximately 1.5 micron 2 and they occupy 0.212% of the cell surface. The average packing density of intramembrane particles or pits in nexuses is approximately 7,200/micron 2 of nexal surface, indicating that there may be approximately 77,000 intercellular channels in the full complement of nexuses of one muscle cell.

scholarly journals Freeze-fracture studies of nexuses between smooth muscle cells. Close relationship to sarcoplasmic reticulum.

1977 ◽  
Vol 72 (1) ◽  
pp. 26-34 ◽  
Author(s):  
G N Fry ◽  
C E Devine ◽  
G Burnstock
Keyword(s):  
Smooth Muscle ◽  
Sarcoplasmic Reticulum ◽  
Guinea Pig ◽  
Hexagonal Lattice ◽  
Freeze Fracture ◽  
Minimum Size ◽  
Mouse Vas Deferens ◽  
Chicken Gizzard ◽  
Close Relationship ◽  
Fracture Appearance

The freeze-fracture appearance of the nexus was compared in the smooth muscle of guinea pig sphincter pupillac, portal vein, pulmonary artery, taenia coli, uretzr, and vas diferens, mouse vas deferens, chicken gizzard and anterior mesenteric artery, and toad stomach. Nexuses are particularly numerous in the guinea pig sphincter pupillae; they are usually oval and their average area is 0.15 mum2, although some as large as 0.6 mum2 were seen. Small aggregations of particles were observed which would not be recognizable as nexuses in thin section. What constitutes the minimum size of a nexus is discussed. It is estimated that the number of nexuses per cell in this preparation is of the order of tens rather than hundreds. All nexuses examined had 6-9-nm particles in the PF face, with corresponding 3-4-nm pits on the EF face forming a polygonal tending towards a hexagonal lattice. The nexuses are arranged in rows parallel to the main axis of the cell, usually alternating with longitudinal rows of plasmalemmal vesicles. Many nexuses in the guinea pig sphincter pupillae, chicken gizzard, and toad stomach show a close relationship with sarcoplasmic reticulum. The possibility that this may have some role in current flow across this specialized junction is discussed.

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