Regional mapping of the gene coding for enolase-2 on human chromosome 12

1982 ◽  
Vol 53 (1) ◽  
pp. 245-254
Author(s):  
M.L. Law ◽  
F.T. Kao
Keyword(s):  
Human Chromosome ◽  
Linear Order ◽  
Segregation Pattern ◽  
Chromosome 12 ◽  
Regional Mapping ◽  
Neuronal Tissue ◽  
Gene Coding ◽  
Mapping Analysis ◽  
Chromosome Breaking ◽  
Hybrid Clones

Enolase-2 (ENO2), previously termed 14-3-2 protein, is an isozyme of enolase that is enriched in neuronal tissue. The gene coding for ENO2 was previously assigned to human chromosome 12. The present study presents data for a regional mapping of gene ENO2 using cell hybrids containing various deletions of human chromosome 12. These deletions were produced by treatment with chromosome-breaking agents. Cytogenetic analysis has allowed assignment of ENO2 to the short arm of chromosome 12, in the region of pter-p1205. This assignment is consistent with the segregation pattern of the 93 hybrid clones analysed. The segregation pattern has also established the linear order of 6 genes on chromosome 12:pter-TPI-GAPD-LDHB-ENO2-centromere-SHMT-PEPB-qter. Estimation of the relative distances between the 6 genes on chromosome 12 has been made by a statistical mapping analysis of the segregation data of the hybrid clones. A set of deletion hybrids containing various combinations of these 6 markers has been established for a rapid regional mapping of genes in one of these regions on chromosome 12.

Confirmation of the assignment of the gene coding for the BA-2 antigen to human chromosome 12

1984 ◽  
Vol 68 (4) ◽  
pp. 351-352 ◽  
Author(s):  
J. J. M. van Dongen ◽  
I. L. M. Tettero ◽  
A. H. M. Geurts van Kessel ◽  
M. A. Versnel ◽  
H. Hooijkaas ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 12 ◽  
Gene Coding

Localization of MODY3 to a 5-cM region of human chromosome 12

Diabetes ◽  
1995 ◽  
Vol 44 (12) ◽  
pp. 1408-1413 ◽  
Author(s):  
S. Menzel ◽  
K. Yamagata ◽  
J. B. Trabb ◽  
J. Nerup ◽  
M. A. Permutt ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 12

Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter

1993 ◽  
Vol 90 (5) ◽  
Author(s):  
M.W. Berchtold ◽  
M. Koller ◽  
R. Egli ◽  
J.A. Rhyner ◽  
H. Hameister ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Intronless Gene ◽  
Gene Coding

scholarly journals Inhibition of prostate cancer metastatic colonization by ?4.2 Mb of human chromosome 12

2003 ◽  
Vol 108 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Erich B. Jaeger ◽  
Marina A. Chekmareva ◽  
Thelma R. Tennant ◽  
Hue H. Luu ◽  
Jonathan A. Hickson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Human Chromosome ◽  
Chromosome 12 ◽  
Metastatic Colonization

Comparative mapping of genes flanking the human chromosome 12 evolutionary breakpoint in the pig

2003 ◽  
Vol 102 (1-4) ◽  
pp. 139-144 ◽  
Author(s):  
C.R. Farber ◽  
N.E. Raney ◽  
V.D. Rilington ◽  
P.J. Venta ◽  
C.W. Ernst
Keyword(s):  
Human Chromosome ◽  
Comparative Mapping ◽  
Chromosome 12 ◽  
Evolutionary Breakpoint

Regional mapping of a liver α-subunit gene of phosphorylase kinase (PHKA) to the distal region of human chromosome Xp

1992 ◽  
Vol 60 (3-4) ◽  
pp. 194-196 ◽  
Author(s):  
J.G. Wauters ◽  
P.J. Bossuyt ◽  
J. Davidson ◽  
J. Hendrickx ◽  
M.W. Kilimann ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Distal Region ◽  
Alpha Subunit ◽  
Phosphorylase Kinase ◽  
Regional Mapping ◽  
Subunit Gene

A Notch-related Gene Located on the Long Arm of Human Chromosome 12

2002 ◽  
pp. 30-31
Author(s):  
David Adamah ◽  
Paul J. Gokhale ◽  
James Walsh ◽  
Peter W. Andrews
Keyword(s):  
Human Chromosome ◽  
Chromosome 12 ◽  
Related Gene

scholarly journals The gene coding for the p68 calcium-binding protein is localised to bands q32?q34 of human chromosome 5, and to mouse chromosome 11

1989 ◽  
Vol 82 (3) ◽  
pp. 234-238 ◽  
Author(s):  
Adelina A. Davies ◽  
Stephen E. Moss ◽  
Mark R. Crompton ◽  
Tania A. Jones ◽  
Nigel K. Spurr ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Chromosome 11 ◽  
Chromosome 5 ◽  
Gene Coding ◽  
Mouse Chromosome 11 ◽  
Human Chromosome 5

The analysis of malignancy by cell fusion. VIII. Evidence for the intervention of an extra-chromosomal element

1977 ◽  
Vol 24 (1) ◽  
pp. 255-263
Author(s):  
J. Jonasson ◽  
H. Harris
Keyword(s):  
Human Chromosome ◽  
Gamma Radiation ◽  
Cell Fusion ◽  
Human Fibroblasts ◽  
Melanoma Cells ◽  
Human Chromosomes ◽  
Mouse Melanoma ◽  
Human Diploid Cells ◽  
Diploid Cells ◽  
Hybrid Clones

Diploid human fibroblasts and lymphocytes were fused with the cells of a malignant mouse melanoma and a range of hybrid clones selected for study. The ability of these clones to produce progressive tumours was assayed in nude mice. Although human chromosomes were preferentially eliminated in all the hybrid clones, the human diploid cells were as effective as mouse diploid cells in suppressing the malignancy of the mouse melanoma cells. The suppression produced by fibroblasts was again more profound than that produced by lymphocytes. Malignancy was also found to be suppressed in a hybrid clone in which a single X was the only human chromosome present; and this clone continued to give a very low take incidence even after the human X had been eliminated by back selection. Hybrids were made between the melanoma cells and diploid human fibroblasts that had been given 100 J kg-1 of gamma radiation before cell fusion. These hybrids contained no recognizable human chromosomes, but their ability to produce progressive tumours was greatly reduced compared to that of the melanoma parent cells. The take incidences given by the crosses between the melanoma cells and the irradiated human fibroblasts were, however, substantially higher than those given by the crosses between the melanoma cells and unirradiated fibroblasts. These findings suggest that the suppression of malignancy involves the activity of some extra-chromosomal element and that this element is radio-sensitive.

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