scholarly journals Supply chain logistics – the role of the Golgi complex in extracellular matrix production and maintenance

2022 ◽  
Vol 135 (1) ◽  
Author(s):  
John Hellicar ◽  
Nicola L. Stevenson ◽  
David J. Stephens ◽  
Martin Lowe
Keyword(s):  
Extracellular Matrix ◽  
Golgi Complex ◽  
Secretory Pathway ◽  
Biochemical Properties ◽  
Vital Role ◽  
Proteolytic Processing ◽  
Post Translational Modification ◽  
Matrix Components ◽  
The Impact

ABSTRACT The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi complex plays a vital role in directing matrix output by co-ordinating the post-translational modification and proteolytic processing of matrix components prior to their secretion. These modifications have broad impacts on the secretion and subsequent assembly of matrix components, as well as their function in the extracellular environment. In this Review, we highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes. We then discuss the impact of Golgi dysfunction on connective tissue in the context of human disease and ageing.

scholarly journals The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1046
Author(s):  
Jorge Martinez ◽  
Patricio C. Smith
Keyword(s):  
Extracellular Matrix ◽  
Type I Collagen ◽  
Cell Metabolism ◽  
Breast Tumors ◽  
Extracellular Matrix Remodeling ◽  
Type I ◽  
Matrix Remodeling ◽  
Desmoplastic Reaction ◽  
The Impact

Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation and early detection. Fibrillar type I collagen is a major component of tumor desmoplasia and its accumulation is causally linked to tumor cell survival and metastasis. For many years, the desmoplastic phenomenon was considered to be a reaction and response of the host tissue against tumor cells and, accordingly, designated as “desmoplastic reaction”. This notion has been challenged in the last decades when desmoplastic tissue was detected in breast tissue in the absence of tumor. This finding suggests that desmoplasia is a preexisting condition that stimulates the development of a malignant phenotype. With this perspective, in the present review, we analyze the role of extracellular matrix remodeling in the development of the desmoplastic response. Importantly, during the discussion, we also analyze the impact of obesity and cell metabolism as critical drivers of tissue remodeling during the development of desmoplasia. New knowledge derived from the dynamic remodeling of the extracellular matrix may lead to novel targets of interest for early diagnosis or therapy in the context of breast tumors.

The role of tendon derived stem/progenitor cells and extracellular matrix components in the bone tendon junction repair

Bone ◽  
2021 ◽  
Vol 153 ◽  
pp. 116172
Author(s):  
Qin Shengnan ◽  
Samuel Bennett ◽  
Wang Wen ◽  
Li Aiguo ◽  
Xu Jiake
Keyword(s):  
Extracellular Matrix ◽  
Progenitor Cells ◽  
Extracellular Matrix Components ◽  
Matrix Components

Role of Extracellular Matrix Components in Adult Rat Adrenal Gland Homeostasis

2004 ◽  
Vol 30 (4) ◽  
pp. 609-610
Author(s):  
Shirley Campbell ◽  
Mélissa Otis ◽  
Nicole Gallo‐Payet ◽  
Marcel Daniel Payet
Keyword(s):  
Extracellular Matrix ◽  
Adrenal Gland ◽  
Adult Rat ◽  
Extracellular Matrix Components ◽  
Matrix Components

The Role Of Social Networking Between Knowledge Donating And Productivity Among Service Sector Employees

2021 ◽  
Vol 3 (1) ◽  
pp. 1-21
Author(s):  
Sarah Khan ◽  
Dr. Nasir Mehmood
Keyword(s):  
Social Networking ◽  
Knowledge Sharing ◽  
Structural Equation ◽  
Service Sector ◽  
Business Environment ◽  
Vital Role ◽  
Mediating Role ◽  
Networking Technologies ◽  
The Impact

Purpose: The purpose of this study is to examine the direct impact of knowledge donating behaviour on employees’ productivity and an indirect effect through social networking technologies. Social networking technologies play a vital role in the growth and learning of individuals and organizations in today’s competitive business environment. Recently, advancement in social networking technologies has brought a paradigm shift in the overall business environment and specific operational requirements. This study aimed to investigate the role of social networking (SN) between knowledge donating behaviour (KD) and employees’ productivity (EP). Methodology: For this purpose, data were gathered from targeted respondents belonged to the Universities and Banks located in the Northern Punjab region of Pakistan. Structural Equation Modelling technique using the SmartPLS was carried to statistically analyse the responses. Findings: The results showed that the hypothesized relationship between knowledge sharing behaviour (KSB) and employee’s productivity was significant and positively related, while social networking played a significant mediating role between this relationship. Implications: The findings provided useful insight to the managers and policymakers for planning effective use of social networking technologies to craft knowledge sharing behaviour among employees to create efficiencies and intended outcomes. Originality: The study has uniquely focused merging phenomenon of knowledge sharing behaviour in the service sector of Pakistan, specifically among academic and financial sector by exploring the impact of social networking technologies and provide valuable future direction for researchers to further extend the underlined idea in the wake of current Covid-19 Pandemic.

scholarly journals Post-Translational Modification-Dependent Activity of Matrix Metalloproteinases

2019 ◽  
Vol 20 (12) ◽  
pp. 3077 ◽  
Author(s):  
Elizabeta Madzharova ◽  
Philipp Kastl ◽  
Fabio Sabino ◽  
Ulrich auf dem Keller
Keyword(s):  
Matrix Metalloproteinases ◽  
Transcriptional Control ◽  
Proteolytic Processing ◽  
Post Translational Modification ◽  
Proteolytic Activation ◽  
Control Of Gene Expression ◽  
Post Translational Modifications ◽  
Binding Partners ◽  
Secreted Proteases

Due to their capacity to process different proteins of the extracellular matrix (ECM), matrix metalloproteinases (MMPs) were initially described as a family of secreted proteases, functioning as main ECM regulators. However, through proteolytic processing of various biomolecules, MMPs also modulate intra- and extracellular pathways and networks. Thereby, they are functionally implicated in the regulation of multiple physiological and pathological processes. Consequently, MMP activity is tightly regulated through a combination of epigenetic, transcriptional, and post-transcriptional control of gene expression, proteolytic activation, post-translational modifications (PTMs), and extracellular inhibition. In addition, MMPs, their substrates and ECM binding partners are frequently modified by PTMs, which suggests an important role of PTMs in modulating the pleiotropic activities of these proteases. This review summarizes the recent progress towards understanding the role of PTMs (glycosylation, phosphorylation, glycosaminoglycans) on the activity of several members of the MMP family.

scholarly journals Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1600
Author(s):  
Nguyen Minh Tuan ◽  
Chang Hoon Lee
Keyword(s):  
Prognostic Biomarker ◽  
Tumour Microenvironment ◽  
Vital Role ◽  
Actin Binding ◽  
Cell Proliferation And Migration ◽  
Novel Target ◽  
And Migration ◽  
The Impact ◽  
Proliferation And Migration

Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here, we gather evidence to determine the applicability of ANLN as a prognostic tool for some types of cancer, and the impact that ANLN has on the hallmarks of cancer. We searched academic repositories including PubMed and Google Scholar to find and review studies related to cancer and ANLN. The conclusion is that ANLN could be a potent target for cancer treatment, but the roles ANLN, other than in cytokinesis and its influence on tumour microenvironment remodeling in cancer development, must be further elucidated, and specific ANLN inhibitors should be found.

scholarly journals Autophagy plays a protective role during Pseudomonas aeruginosa-induced apoptosis via ROS–MAPK pathway

2020 ◽  
Vol 26 (7) ◽  
pp. 580-591
Author(s):  
Lu Han ◽  
Qinmei Ma ◽  
Jialin Yu ◽  
Zhaoqian Gong ◽  
Chenjie Ma ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Mapk Pathway ◽  
Protective Role ◽  
Vital Role ◽  
Raw264.7 Cells ◽  
Cellular Reactive Oxygen Species ◽  
Induced Apoptosis ◽  
Related Proteins ◽  
The Impact

Pseudomonas aeruginosa infection can induce alveolar macrophage apoptosis and autophagy, which play a vital role in eliminating pathogens. These two processes are usually not independent. Recently, autophagy has been found to interact with apoptosis during pathogen infections. Nevertheless, the role of autophagy in P. aeruginosa-infected cell apoptosis is unclear. In this study, we explored the impact of P. aeruginosa infection on autophagy and apoptosis in RAW264.7 cells. The autophagy activator rapamycin was used to stimulate autophagy and explore the role of autophagy on apoptosis in P. aeruginosa-infected RAW264.7 cells. The results indicated that P. aeruginosa infection induced autophagy and apoptosis in RAW264.7 cells, and that rapamycin could suppress P. aeruginosa-induced apoptosis by regulating the expression of apoptosis-related proteins. In addition, rapamycin scavenged the cellular reactive oxygen species (ROS) and diminished p-JNK, p-ERK1/2 and p-p38 expression of MAPK pathways in RAW264.7 cells infected with P. aeruginosa. In conclusion, the promotion of autophagy decreased P. aeruginosa-induced ROS accumulation and further attenuated the apoptosis of RAW264.7 cells through MAPK pathway. These results provide novel insights into host–pathogen interactions and highlight a potential role of autophagy in eliminating P. aeruginosa.

scholarly journals Role of The Family in Entrepreneurship Develoment in Nepali Society

2016 ◽  
Vol 9 (1) ◽  
pp. 37-47 ◽  
Author(s):  
Sushil Kumar Pant
Keyword(s):  
Economic Growth ◽  
Statistical Tests ◽  
Job Creation ◽  
Vital Role ◽  
Ethnic Communities ◽  
Entrepreneurship Research ◽  
Entrepreneurship Development ◽  
The Family ◽  
The Impact

Entrepreneurship is the engine for social and economic growth of any society. It drives people toward wealth and job creation, which leads to better lives for people in the society. There has been growing interest in entrepreneurship research recently. This paper attempted to assess the impact of family in Nepalese society. This was viewed as essential in a country in which more than 125 ethnic communities are found. The findings show that family has some impact in people to become entrepreneurship but it was not strongly substantiated by statistical tests. It was found that entrepreneur’s parental profession plays some role in entrepreneurship development in Nepal which was similar to some findings that parental profession plays vital role in the choice of profession in children.Journal of Nepalese Bussiness Studies Vol. 9, No. 1, 2015 pp. 37-47

Toward a Perspective on R&D Outsourcing: RBV and Firm Performance

2018 ◽  
Vol 15 (05) ◽  
pp. 1850040 ◽  
Author(s):  
Anne W. Fuller
Keyword(s):  
Decision Making ◽  
Firm Performance ◽  
Research And Development ◽  
Competitive Advantage ◽  
Industrial Research ◽  
Vital Role ◽  
Decision Making Process ◽  
Resource Based View ◽  
The Impact

This paper looks at the vital role of industrial research and development (R&D). The increased outsourcing of industrial R&D is contrasted with a resource-based view of competitive advantage which maintains capabilities that are valuable, rare, imitable, and non-substitutable (VRIN), and should be internalized in the firm. Traditional business formation literature is also supportive of keeping R&D “inhouse”. R&D outsourcing research is leveraged to posit possible reasons for the increased amount of outsourced R&D. Testable propositions are included that look at factors for R&D outsource decisions and also the impact of these decisions on firm performance. An R&D entropy statistic is introduced as well as several R&D characteristics useful in the decision-making process to create R&D.

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