scholarly journals CREB regulates the expression of Type 1 Inositol 1,4,5-trisphosphate receptors

2021 ◽  
Author(s):  
Vikas Arige ◽  
Lara E. Terry ◽  
Sundeep Malik ◽  
Taylor R. Knebel ◽  
Larry E. Wagner ◽  
...  
Keyword(s):  
Long Term Effects ◽  
Ip3 Receptors ◽  
Chronic Stimulation ◽  
Interacting Protein ◽  
Post Translational Modifications ◽  
Over Expression ◽  
Pathological Conditions ◽  
Inositol 1,4,5 Trisphosphate

Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) play a central role in regulating intracellular calcium signals in response to a variety of internal/external cues. Dysregulation of IP3R signaling is the underlying cause for numerous pathological conditions. It is well established that the activities of IP3Rs are governed by several post-translational modifications including phosphorylation by protein kinase A (PKA). However, the long-term effects of PKA activation on expression of IP3R sub-types, remains largely unexplored. In this report, we investigate the effects of more chronic stimulation and tonic activity of PKA on the expression of IP3R sub-types. We demonstrate that the expression of IP3R1 is augmented upon prolonged activation of PKA or upon ectopic over-expression of CREB without altering IP3R2 and IP3R3 abundance. Conversely, inhibition of PKA or blocking CREB diminished IP3R1 expression. We also demonstrate that agonist-induced Ca2+-release mediated by IP3R1 is significantly attenuated upon blocking CREB. Moreover, CREB by regulating the expression of KRAS-induced actin-interacting protein (KRAP) ensures proper localization and licensing of IP3R1. Overall, we report a crucial role for CREB in governing both the expression and proper localization of IP3R1.

Treatments for Pathological Gambling and Other Impulse Control Disorders

2007 ◽  
pp. 561-578 ◽  
Author(s):  
Jon E. Grant ◽  
Marc N. Potenza
Keyword(s):  
Pathological Gambling ◽  
Pharmacological Treatment ◽  
Impulse Control ◽  
Behavioral Therapy ◽  
Impulse Control Disorders ◽  
Long Term Effects ◽  
Drug Treatments

Several controlled outcome studies (Type 1 and Type 2) suggest that specific behavioral (e.g., cognitive-behavioral therapy [CBT]) and pharmacological (e.g., naltrexone, nalmefene, lithium) treatments significantly reduce the symptoms of pathological gambling in the short term compared with wait-list or placebo. Although long-term effects of manual-based CBT have been observed in several small studies, the long-term benefits of pharmacological treatment have not been adequately tested. No studies combining behavioral and pharmacological therapies have been published to date. Thus, the potential benefit of combining behavioral and drug treatments for pathological gambling remains to be investigated systematically. Although several studies (Type 1 and Type 2) suggest that CBT is effective for trichotillomania, pharmacological treatment studies for this disorder have shown mixed results. Similarly, controlled pharmacological studies (Type 1 and Type 2) of compulsive buying have demonstrated mixed results. Limited treatment studies exist for other impulse control disorders (kleptomania, intermittent explosive disorder), although various pharmacological and psychological treatments have shown promise in uncontrolled studies.

Tyrosinemia Type I

2016 ◽  
Author(s):  
David Cassiman ◽  
Wouter Meersseman
Keyword(s):  
Bone Disease ◽  
Type I ◽  
Long Term Effects ◽  
Liver Malignancy ◽  
Tyrosinemia Type I ◽  
Plasma Tyrosine ◽  
Rare Metabolic Disorder

Tyrosinemia type 1 (HT-1) is a rare metabolic disorder affecting degradation pathways of the amino acid tyrosine. HT-1 presents with liver, kidney and/or bone disease and can cause acute porphyria attacks. Biochemical diagnosis is made by measuring raised plasma tyrosine and detection of succinylacetone in urine. Long-term management with diet and nitisinone leads to excellent short term results, but since long term effects are largely unknown, life-long treatment and follow-up for liver malignancy, bone disease and kidney disease seem necessary. HT-1 is treatable by liver transplantation.

scholarly journals Long-Term Effects of Highly Active Antiretroviral Therapy in Pretreated, Vertically HIV Type 1-Infected Children: 6 Years of Follow-Up

2006 ◽  
Vol 42 (6) ◽  
pp. 862-869 ◽  
Author(s):  
S. Resino ◽  
R. Resino ◽  
D. Micheloud ◽  
D. Gurbindo-Gutierrez ◽  
J. A. Leon ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Long Term Effects ◽  
Highly Active ◽  
Hiv Type 1

Long-term effects of the ketogenic diet on growth in children with resistant drug epilepsy and Glucose Transporter Type 1 Deficiency Syndrome

2019 ◽  
Vol 29 (8) ◽  
pp. 884
Author(s):  
Cinzia Ferraris ◽  
Valentina De Giorgis ◽  
Ilaria Brambilla ◽  
Monica Guglielmetti ◽  
Claudia Trentani ◽  
...  
Keyword(s):  
Ketogenic Diet ◽  
Glucose Transporter ◽  
Deficiency Syndrome ◽  
Long Term Effects

Reactive oxygen species participate in acute renal vasoconstrictor responses induced by ETA and ETB receptors

2008 ◽  
Vol 294 (4) ◽  
pp. F719-F728 ◽  
Author(s):  
Armin Just ◽  
Christina L. Whitten ◽  
William J. Arendshorst
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Long Term Effects ◽  
Vasomotor Tone ◽  
Chronic Stimulation ◽  
Renal Vasoconstriction ◽  
Oxidase Inhibition

Reactive oxygen species (ROS) play important roles in renal vasoconstrictor responses to acute and chronic stimulation by angiotensin II and norepinephrine, as well as in long-term effects of endothelin-1 (ET-1). Little is known about participation of ROS in acute vasoconstriction produced by ET-1. We tested the influence of NAD(P)H oxidase inhibition by apocynin [4 mg·kg−1·min−1, infused into the renal artery (ira)] on ETA and ETB receptor signaling in the renal microcirculation. Both receptors were stimulated by ET-1, ETA receptors by ET-1 during ETB antagonist BQ-788, and ETB by ETB agonist sarafotoxin 6C. ET-1 (1.5 pmol injected ira) reduced renal blood flow (RBF) 17 ± 4%. Apocynin raised baseline RBF (+10 ± 1%, P < 0.001) and attenuated the ET-1 response to 10 ± 2%, i.e., 35 ± 9% inhibition ( P < 0.05). Apocynin reduced ETA-induced vasoconstriction by 42 ± 12% ( P < 0.05) and that of ETB stimulation by 50 ± 8% ( P < 0.001). During nitric oxide (NO) synthase inhibition ( Nω-nitro-l-arginine methyl ester), apocynin blunted ETA-mediated vasoconstriction by 60 ± 8% ( P < 0.01), whereas its effect on the ETB response (by 87 ± 8%, P < 0.001) was even larger without than with NO present ( P < 0.05). The cell-permeable superoxide dismutase mimetic tempol (5 mg·kg−1·min−1 ira), which reduces O2− and may elevate H2O2, attenuated ET-1 responses similar to apocynin (by 38 ± 6%, P < 0.01). We conclude that ROS, O2− rather than H2O2, contribute substantially to acute renal vasoconstriction elicited by both ETA and ETB receptors and to basal renal vasomotor tone in vivo. This physiological constrictor action of ROS does not depend on scavenging of NO. In contrast, scavenging of O2− by NO seems to be more important during ETB stimulation.

Long-term effects of eating sucrose on metabolic control of type 1 (insulin-dependent) diabetic outpatients

1990 ◽  
Vol 27 (4) ◽  
pp. 365-370 ◽  
Author(s):  
Giovanna Santacroce ◽  
Gabriele Forlani ◽  
Silvio Giangiulio ◽  
Valeria Galuppi ◽  
Manuela Pagani ◽  
...  
Keyword(s):  
Metabolic Control ◽  
Long Term Effects ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic
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