scholarly journals Cell Scientist to Watch – Eurico Morais-de-Sá

2020 ◽  
Vol 133 (23) ◽  
pp. jcs256040
Keyword(s):  
Cell Division ◽  
Epithelial Cell ◽  
Cell Polarity ◽  
Research Group ◽  
Cell Biology ◽  
Epithelial Tissue ◽  
Marie Curie ◽  
Regulatory Processes ◽  
Spatial Asymmetry ◽  
The University

ABSTRACTEurico Morais-de-Sá graduated in biochemistry from the University of Porto, Portugal. After a research internship in protein crystallography at the Institute for Molecular and Cell Biology (IBMC) in Porto, Eurico moved to Cambridge, UK, to do his PhD with Daniel St Johnston at the Gurdon Institute. During this time, he studied cell polarity in the context of epithelial tissue and body-axis specification. In 2011, he was awarded EMBO and Marie Curie fellowships to return to Porto for his postdoctoral work with Claudio Sunkel at IBMC, where he used his cell polarity expertise to understand the regulatory processes of epithelial cell division. In 2018, Eurico established his own research group at Instituto de Inovação e Investigação em Saúde (i3S) focusing on the mechanisms by which epithelial cells modulate spatial asymmetry during cell division to maintain the function and integrity of proliferative tissues.

scholarly journals Cell scientist to watch – Romain Levayer

2021 ◽  
Vol 134 (2) ◽  
pp. jcs256487
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Cell Biology ◽  
Young Scientist ◽  
Epithelial Morphogenesis ◽  
Cell Competition ◽  
Master's Degrees ◽  
Johns Hopkins University ◽  
University Of Bern ◽  
The University

ABSTRACTRomain Levayer did his bachelor's and master's degrees at École Normale Supérieure in Paris, France. In between these degrees, he did an internship in the lab of Geraldine Seydoux, at Johns Hopkins University in Baltimore, MD, USA. He then moved to Marseille, France, to join the laboratory of Thomas Lecuit at the Institut de Biologie du Développement de Marseille (IBDM) for his PhD. There, he studied epithelial morphogenesis during the early development of the Drosophila embryo. Postdoctoral work followed in the lab of Eduardo Moreno at the Institute of Cell Biology (IZB) at the University of Bern, Switzerland, where Romain investigated the mechanisms of epithelial cell competition. At the end of 2016, Romain returned to Paris to establish his research group at Institut Pasteur. His lab is trying to understand how the plasticity of behaviour of epithelial cells and the regulation of cell death modulate tissue morphogenesis and homeostasis. Romain was awarded an ERC Starting Grant in 2017 and the SBCF Young Scientist Award in 2018, and he was one of the laureates of La Fondation Schlumberger pour l'Education et la Recherche (FSER) in 2019.

scholarly journals Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

2008 ◽  
Vol 183 (4) ◽  
pp. 625-633 ◽  
Author(s):  
Aron B. Jaffe ◽  
Noriko Kaji ◽  
Joanne Durgan ◽  
Alan Hall
Keyword(s):  
Cell Division ◽  
Epithelial Cell ◽  
Three Dimensional ◽  
Epithelial Morphogenesis ◽  
Spindle Orientation ◽  
Epithelial Cell Line ◽  
Epithelial Tissue ◽  
Apical Surface ◽  
Apical Domain ◽  
Underlying Mechanisms

The establishment of apical–basal polarity within a single cell and throughout a growing tissue is a key feature of epithelial morphogenesis. To examine the underlying mechanisms, the human intestinal epithelial cell line Caco-2 was grown in a three-dimensional matrix to generate a cystlike structure, where the apical surface of each epithelial cell faces a fluid-filled central lumen. A discrete apical domain is established as early as the first cell division and between the two daughter cells. During subsequent cell divisions, the apical domain of each daughter cell is maintained at the center of the growing structure through a combination of mitotic spindle orientation and asymmetric abscission. Depletion of Cdc42 does not prevent the establishment of apical–basal polarity in individual cells but rather disrupts spindle orientation, leading to inappropriate positioning of apical surfaces within the cyst. We conclude that Cdc42 regulates epithelial tissue morphogenesis by controlling spindle orientation during cell division.

The Bastion of Christendom

2020 ◽  
Vol 25 (2) ◽  
pp. 281-304
Author(s):  
Orsolya Száraz
Keyword(s):  
Cultural Studies ◽  
Collective Memory ◽  
Research Group ◽  
Basic Hypothesis ◽  
And Function ◽  
The University ◽  
Meaning And Function

The Institute of Hungarian Literary and Cultural Studies at the University of Debrecen formed a research group in 2010 in order to launch the research of Hungarian realms of memory. This paper was written within the frameworks of the research group. Its basic hypothesis is that the identification of Hungary as the Bastion of Christendom is an established part of Hungarian collective memory. This paper attempts to demonstrate the changes of this realm of memory, regarding its meaning and function, from its formation up to the present day.

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