scholarly journals β1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion

2020 ◽  
Vol 133 (9) ◽  
pp. jcs239152 ◽  
Author(s):  
Olivia R. Grafinger ◽  
Genya Gorshtein ◽  
Tyler Stirling ◽  
Megan I. Brasher ◽  
Marc G. Coppolino
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Β1 Integrin ◽  
Promote Tumor Cell ◽  
Promote Tumor Cell Invasion

scholarly journals Single-Cell Transcriptomic Analysis Reveals Two Molecularly and Clinically Distinct Subtypes of Intrahepatic Cholangiocarcinoma

2021 ◽  
Author(s):  
Song Guohe ◽  
Yang Shi ◽  
Lu Meng ◽  
Siyuan Huang ◽  
Jiaqiang Ma ◽  
...  
Keyword(s):  
T Cells ◽  
Single Cell ◽  
Tumor Cells ◽  
Cell Invasion ◽  
Intrahepatic Cholangiocarcinoma ◽  
Tumor Cell Invasion ◽  
Hepatocyte Differentiation ◽  
Single Cell Rna Sequencing ◽  
Promote Tumor Cell ◽  
Promote Tumor Cell Invasion

Abstract Intrahepatic cholangiocarcinoma (iCCA) is a highly heterogeneous cancer with limited understanding of its classification and tumor microenvironment. Here, we performed single-cell RNA sequencing on 144,878 cells from 14 pairs of iCCA tumors and non-tumor liver tissues. We found that S100P and SPP1 are two reliable markers for iCCA perihilar large duct type (iCCAphl) and peripheral small duct type (iCCApps). S100P + SPP1- iCCAphl has significantly reduced levels of infiltrating CD3+ T cells, CD56+ NK cells, and increased CCL18+ macrophages compared to S100P-SPP1 + iCCApps. The transcriptor CREB3L1 is identified to regulate the S100P expression and promote tumor cell invasion. S100P-SPP1 + iCCApps has significantly more SPP1+ macrophage infiltration, less aggressiveness and better survival than S100P + SPP1- iCCAphl. Moreover, S100P-SPP1 + iCCApps harbors tumor cells at different status of differentiation, such as ALB + hepatocyte differentiation and ID3 + stemness. Our study extends our understanding of the diversity of tumor cells in iCCA and provides clearer understanding of iCCA classification.

CUTL1–a modulator of tumor cell invasion and target of TGF-beta which is highly expressed in colon cancer

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
P Michl ◽  
M Ei'Bahrawy ◽  
R Poulsom ◽  
A Ramjaun ◽  
J Downward
Keyword(s):  
Colon Cancer ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Tgf Beta

Tumor Cell Invasion Assay

BIO-PROTOCOL ◽  
2012 ◽  
Vol 2 (3) ◽  
Author(s):  
Yanling Chen
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Invasion Assay
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