scholarly journals The gap junction protein connexin 43 controls multiple aspects of cranial neural crest cell development

2020 ◽  
Vol 133 (4) ◽  
pp. jcs235440 ◽  
Author(s):  
Karyn Jourdeuil ◽  
Lisa A. Taneyhill
Keyword(s):  
Neural Crest ◽  
Gap Junction ◽  
Connexin 43 ◽  
Neural Crest Cell ◽  
Cell Development ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Junction Protein ◽  
Gap Junction Protein ◽  
Crest Cell

Inhibition of cranial neural crest cell development by vitamin A in the cultured chick embryo

Development ◽  
1977 ◽  
Vol 39 (1) ◽  
pp. 267-271
Author(s):  
John R. Hassell ◽  
Judith H. Greenberg ◽  
Malcolm C. Johnston
Keyword(s):  
Vitamin A ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Cell Development ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Neural Crest Cell Migration ◽  
Cranial Neural Crest Cells ◽  
Crest Cell ◽  
Whole Egg

Chick embryos at stage 8, prior to neural crest cell migration, were explanted on whole egg medium with or without vitamin A and cultured for 3 days. Sections through the head regions showed that the cranial neural crest cells had migrated into the first visceral arch in the controls but were absent from this structure in the treated embryos. These observations suggest that vitamin A inhibits neural crest cell development or migration, an effect which may in part account for the facial malformations produced by excess vitamin A.

scholarly journals Connexin 43 impacts the chick premigratory cranial neural crest cell population without affecting the neural crest cell epithelial-to-mesenchymal transition

2019 ◽  
Author(s):  
Karyn Jourdeuil ◽  
Lisa A. Taneyhill
Keyword(s):  
Gap Junctions ◽  
Neural Crest ◽  
Gap Junction ◽  
Neural Crest Cell ◽  
Neural Crest Cells ◽  
Cranial Neural Crest ◽  
Mesenchymal Transition ◽  
Junction Protein ◽  
Cranial Neural Crest Cells ◽  
Crest Cell

ABSTRACTGap junctions are intercellular channels that allow for the diffusion of small ions and solutes between coupled cells. Connexin 43 (Cx43), also known as Gap Junction Protein α1, is the most broadly expressed gap junction protein in vertebrate development. Cx43 is strongly expressed in premigratory cranial neural crest cells and is maintained throughout the neural crest cell epithelial-to-mesenchymal transition (EMT), but its function in these cells is not known. To this end, we have used a combination of in vivo and ex vivo live imaging with confocal microscopy, immunohistochemistry, and functional assays to assess gap junction formation, and Cx43 function, in chick premigratory cranial neural crest cells. Our results demonstrate that gap junctions exist between chick premigratory and migratory cranial neural crest cells, with Cx43 depletion inhibiting the function of gap junctions. While a reduction in Cx43 levels just prior to neural crest cell EMT did not affect EMT and subsequent emigration of neural crest cells from the neural tube, the size of the premigratory neural crest cell domain was decreased in the absence of any changes in cell proliferation or death. Collectively, these data identify a role for Cx43 within the chick premigratory cranial neural crest cell population prior to EMT and migration.

scholarly journals The tight junction protein claudin-1 influences cranial neural crest cell emigration

2012 ◽  
Vol 129 (9-12) ◽  
pp. 275-283 ◽  
Author(s):  
Katherine J. Fishwick ◽  
Theresa E. Neiderer ◽  
Sharon Jhingory ◽  
Marianne E. Bronner ◽  
Lisa A. Taneyhill
Keyword(s):  
Tight Junction ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Tight Junction Protein ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Junction Protein ◽  
Crest Cell

scholarly journals Proliferation dynamics associated with cranial neural crest cell migration

2011 ◽  
Vol 356 (1) ◽  
pp. 197
Author(s):  
Dennis A. Ridenour ◽  
Rebecca McLennan ◽  
Jessica M. Teddy ◽  
Katherine W. Prather ◽  
Craig L. Semerad ◽  
...  
Keyword(s):  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Neural Crest Cell Migration ◽  
Crest Cell

scholarly journals Ric-8A, a GEF for heterotrimeric G-proteins, controls cranial neural crest cell polarity during migration

2018 ◽  
Vol 154 ◽  
pp. 170-178 ◽  
Author(s):  
Juan Ignacio Leal ◽  
Soraya Villaseca ◽  
Andrea Beyer ◽  
Gabriela Toro-Tapia ◽  
Marcela Torrejón
Keyword(s):  
Neural Crest ◽  
G Proteins ◽  
Cell Polarity ◽  
Neural Crest Cell ◽  
Heterotrimeric G Proteins ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Crest Cell

Regulation of cranial neural crest cell fate by Irf6 and Twist1 interaction

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Walid D. Fakhouri ◽  
Jessica Wildgrube Bertol ◽  
Victoria K. Xie ◽  
Shelby Johnston ◽  
Kelsea Hubka ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Neural Crest Cell ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Crest Cell
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