scholarly journals MKL1 overexpression predicts poor prognosis in patients with papillary thyroid cancer and promotes nodal metastasis

2019 ◽  
Vol 132 (16) ◽  
pp. jcs231399 ◽  
Author(s):  
Xian Cheng ◽  
Shichen Xu ◽  
Jie Pan ◽  
Jiangxia Zheng ◽  
Xiaowen Wang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Poor Prognosis ◽  
Nodal Metastasis ◽  
Papillary Thyroid

scholarly journals Preoperative Low 25-hydroxyvitamin D Level Is Associated With Poor Prognosis of Papillary Thyroid Cancer

2021 ◽  
Author(s):  
Munire Abuduwaili ◽  
Zhichao Xing ◽  
Yuan Fei ◽  
Baoying Xia ◽  
Jingqiang Zhu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Poor Prognosis ◽  
Central Area ◽  
Papillary Thyroid ◽  
Prognosis Factors ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
D 20

Abstract Purpose: To evaluate the relationship between preoperative 25-hydroxyvitamin D (25[OH]D) level and poor prognosis factors of papillary thyroid cancer.Methods: A total of 1198 patients diagnosed of papillary thyroid cancer were analyzed retrospectively. Patients were categorized into vitamin D deficiency (VDD) group and normal group according to preoperative 25(OH)D＜20 ng/mL and 25(OH)D≥20 ng/mL. Differences of demographic date and clinicopathological characteristics were analyzed between two groups. Liner and logistic regression analysis to determine the effect of 25(OH)D on the established poor prognosis factors of papillary thyroid cancer were also applied.Results: We observed a negative liner correlation between 25(OH)D levels and tumor size and an independent relationship between VDD and lymph node metastasis in central area. Additionally, there was a significant correlation between preoperative 25(OH)D and thyroid-stimulating hormone (TSH) levels.Conclusions: 25(OH)D level significantly associated with certain poor prognosis factors of papillary thyroid cancer. Assessing and supplementing vitamin D may be an important addition to preoperative management of patients with papillary thyroid cancer.

scholarly journals Blood prognostic predictors of treatment response for patients with papillary thyroid cancer

2020 ◽  
Vol 40 (10) ◽  
Author(s):  
Xiangxiang Liu ◽  
Zhongke Huang ◽  
Xianghui He ◽  
Xiangqian Zheng ◽  
Qiang Jia ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Poor Prognosis ◽  
Response To Therapy ◽  
Prognostic Indicators ◽  
High Morbidity ◽  
American Thyroid Association ◽  
Papillary Thyroid ◽  
Distribution Width ◽  
Prognosis Group

Abstract Background: Papillary thyroid cancer (PTC) is a very common malignant disease with high morbidity. We needed some pretreatment indicators to help us predict prognosis and guide treatment. We conducted a study about some pretreatment prognostic indicators. Methods: This clinical study recruited 705 postoperative PTC patients (211 males, 494 females). Clinical data before radioactive iodine (RAI) treatment were collected. Patients’ response to therapy were classified into two categories: ‘Good Prognosis Group’ (GPG) and ‘Poor Prognosis Group’ (PPG), according to ‘2015 American Thyroid Association Guidelines’. Differences of indicators between different prognosis groups were compared. Odds ratios (ORs) were calculated by univariate/multiple binary logistic regression models. Difference of body mass index (BMI) changes before and after RAI treatment between different prognosis groups was also compared. Results: A total of 546 (77.45%) belonged to GPG, and 159 (22.55%) belonged to PPG. Platelet (PLT), neutrophil (NEUT), PLT subgroups, and combination of red blood cell distribution width (RDW) and BMI (COR-BMI) were different between two prognosis groups. The significance of the difference between the two groups of BMI disappeared after the Bonferroni correction. PLT and PLT subgroups had detrimental effects on the risk of PPG; T stage had a positive effect on the risk of PPG. PLT subgroup showed a detrimental effect on the risk of PPG when we included additional covariates. Conclusions: We found that lower pretreatment PLT levels may indicate a poor prognosis for PTC. The relationship between platelet-derived growth factor (PDGF) and radiation sensitivity may be the key to this association.

Posterosuperior Lesion has a High Risk of Lateral and Central Nodal Metastasis in Solitary Papillary Thyroid Cancer

2014 ◽  
Vol 39 (2) ◽  
pp. 387-392 ◽  
Author(s):  
Dong Jin Lee ◽  
Kyu Ho Lee ◽  
Jin Hwan Kim ◽  
Kee Hwan Kwon ◽  
Dae Young Yoon ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
High Risk ◽  
Papillary Thyroid Cancer ◽  
Nodal Metastasis ◽  
Papillary Thyroid ◽  
Central Nodal Metastasis

High Risk of Lateral Nodal Metastasis in Lateral Solitary Solid Papillary Thyroid Cancer

2016 ◽  
Vol 42 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Xing-Jian Lai ◽  
Bo Zhang ◽  
Yu-Xin Jiang ◽  
Jian-Chu Li ◽  
Rui-Na Zhao ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
High Risk ◽  
Papillary Thyroid Cancer ◽  
Nodal Metastasis ◽  
Papillary Thyroid

scholarly journals Pattern of regional metastasis in papillary thyroid cancer: our experience of 86 cases

2019 ◽  
Vol 7 (9) ◽  
pp. 3362
Author(s):  
Rajjyoti Das ◽  
Jagannath D. Sharma ◽  
Amal Ch Kataki ◽  
Chandi R. Kalita ◽  
Nizara Baishya
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Neck Dissection ◽  
Papillary Thyroid Cancer ◽  
Nodal Metastasis ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Regional Metastasis

Background: Papillary thyroid cancer (PTC) have a high propensity for regional metastasis which ranges from 30- 80%. The objective of the study is to assess the pattern of lymph node metastasis and to plan the extent of neck dissection accordingly. Though central neck dissection (CND) is routinely done in PTC but the indication of extent of  neck dissection is still controversial.Methods: The medical records of   86 patients with PTC  who underwent total thyroidectomy (TT) and neck dissection at Dr. B. Borooah Cancer Institute(BBCI) from January 2010 to  December 2014 were retrospectively reviewed.Results: Out of 86 patients 22 were males and 64 were females. The median age of presentation was 40.0 years. 43 out of 86 patients (50%) had cervical lymph node metastasis. Ipsilateral nodal metastasis was found in 37 patients (43.0%) and contralateral metastasis was found in only 6 patients (7.0%).Tumors with size more than 3cm had ipsilateral nodal metastasis in 21(56.7%) patients which is statistically significant (p 0.03).A strong association was found between level VI and the ipsilateral group of lymph nodes involving level II,III,IV and V.Conclusions: Majority of patients present with multiple level nodal metastasis, with the central compartment commonly involved. In view of the high incidence of metastatic lymph nodes in levels II, III, IV and level VI ,our study  supports the recommendation  for posterolateral  and anterior  neck dissection in patients with clinically positive neck  nodes and tumor with aggressive criteria.

Overexpression of miR-127 Predicts Poor Prognosis and Contributes to the Progression of Papillary Thyroid Cancer by Targeting REPIN1

2020 ◽  
Author(s):  
Yinghe Sun ◽  
Wenhai Sun ◽  
Hui Hua ◽  
Jianhua Zhang ◽  
Qianqian Yu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Poor Prognosis ◽  
Cox Regression ◽  
Tnm Stage ◽  
Prognostic Indicators ◽  
Migration And Invasion ◽  
Papillary Thyroid ◽  
Cox Regression Analysis

AbstractPapillary thyroid cancer (PTC) is a major kind of thyroid cancer with increasing recurrence and metastasis. MiR-127 has been demonstrated to play roles in many cancers with dysregulation. However, the function of miR-127 is still unknown. This study aimed to explore a novel biomarker for the progression and prognosis of PTC. A set of 118 patients with PTC were collected from the Affiliated Hospital of Qingdao University. qRT-PCR was used to detect the expression of miR-127 in PTC tissues and cells. The association between miR-127 expression and the clinicopathological features of patients were evaluated by the χ2 test, and the prognostic value of miR-127 was evaluated by Kaplan–Meier analysis and Cox regression analysis. The effect of miR-127 on cell proliferation, migration, and invasion of PTC was analyzed by CCK-8 and transwell assay. miR-127 was found to be upregulated in PTC tissues and cells correlated with the TNM stage and poor prognosis of PTC patients. MiR-127 and the TNM stage were considered as two independent prognostic indicators for PTC. Moreover, overexpression of miR-127 significantly enhanced cell proliferation, migration, and invasion of PTC by targeting REPIN1. miR-127 may be involved in the progression of PTC, which provides a new therapeutic strategy for PTC.

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