scholarly journals Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling

2018 ◽  
Vol 131 (14) ◽  
pp. jcs217406 ◽  
Author(s):  
Qiuling Li ◽  
Jie Jiao ◽  
Huijun Li ◽  
Huajing Wan ◽  
Caihong Zheng ◽  
...  
Keyword(s):  
Branching Morphogenesis ◽  
Arginine Methylation ◽  
Bmp Signaling ◽  
Histone Arginine Methylation ◽  
Lung Branching

scholarly journals Abrogation of Transforming Growth Factor-β Type II Receptor Stimulates Embryonic Mouse Lung Branching Morphogenesis in Culture

1996 ◽  
Vol 180 (1) ◽  
pp. 242-257 ◽  
Author(s):  
Jingsong Zhao ◽  
Ding Bu ◽  
Matt Lee ◽  
Harold C. Slavkin ◽  
Frederick L. Hall ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Branching Morphogenesis ◽  
Mouse Lung ◽  
Type Ii ◽  
Embryonic Mouse ◽  
Lung Branching

scholarly journals Impaired Lung Branching Morphogenesis in the Absence of Functional EGF Receptor

1997 ◽  
Vol 186 (2) ◽  
pp. 224-236 ◽  
Author(s):  
Päivi J. Miettinen ◽  
David Warburton ◽  
Ding Bu ◽  
Jing-Song Zhao ◽  
Joel E. Berger ◽  
...  
Keyword(s):  
Egf Receptor ◽  
Branching Morphogenesis ◽  
Lung Branching

scholarly journals Models of lung branching morphogenesis

2015 ◽  
Vol 157 (3) ◽  
pp. 121-127 ◽  
Author(s):  
T. Miura
Keyword(s):  
Branching Morphogenesis ◽  
Lung Branching

scholarly journals Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors

Development ◽  
2013 ◽  
Vol 140 (18) ◽  
pp. 3731-3742 ◽  
Author(s):  
T. Volckaert ◽  
A. Campbell ◽  
E. Dill ◽  
C. Li ◽  
P. Minoo ◽  
...  
Keyword(s):  
Branching Morphogenesis ◽  
Fgf10 Expression ◽  
Lung Branching

scholarly journals PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Stephan Kolodziej ◽  
Olga N. Kuvardina ◽  
Thomas Oellerich ◽  
Julia Herglotz ◽  
Ingo Backert ◽  
...  
Keyword(s):  
Arginine Methylation ◽  
Histone Arginine Methylation

PDGF-AA and its receptor influence early lung branching via an epithelial-mesenchymal interaction

Development ◽  
1995 ◽  
Vol 121 (8) ◽  
pp. 2559-2567 ◽  
Author(s):  
P. Souza ◽  
M. Kuliszewski ◽  
J. Wang ◽  
I. Tseu ◽  
A.K. Tanswell ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Critical Role ◽  
Polymerase Chain Reaction Analysis ◽  
Branching Morphogenesis ◽  
Inhibitory Effect ◽  
Embryonic Lung ◽  
Morphometric Analyses ◽  
Terminal Buds ◽  
Lung Branching

The biological role of platelet-derived growth factor (PDGF)-AA in lung morphogenesis was investigated by incubating embryonic lung explants with phosphorothioate antisense PDGF-A oligonucleotides, which decreased PDGF-AA but not PDGF-BB protein content. Antisense PDGF-A oligonucleotides inhibited DNA synthesis. This inhibitory effect of antisense PDGF-A was reversed by the addition of exogenous PDGF-AA but not PDGF-BB. Morphometric analyses of antisense-treated cultures showed a significant reduction in lung size. The number of terminal buds of the lung explants was significantly decreased by antisense PDGF-A oligonucleotides. PDGF-AA but not PDGF-BB attenuated the inhibitory effect of antisense PDGF-A on early lung branching. Sense PDGF-A had no effect on DNA synthesis and early lung branching. Reverse transcriptase-polymerase chain reaction analysis revealed PDGF-A mRNA expression in the epithelial component of the embryonic lung, while message for PDGF alpha-receptor was expressed in the mesenchyme. Incubation of explants with neutralizing PDGF-AA antibodies also reduced DNA synthesis and early branching morphogenesis. We conclude that PDGF-AA and its receptor represent an important epithelial-mesenchymal interaction which plays a critical role in early lung branching morphogenesis.

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