scholarly journals SNAP-25 gene family members differentially support secretory vesicle fusion

2017 ◽  
Vol 130 (11) ◽  
pp. 1877-1889 ◽  
Author(s):  
Swati Arora ◽  
Ingrid Saarloos ◽  
Robbelien Kooistra ◽  
Rhea van de Bospoort ◽  
Matthijs Verhage ◽  
...  
Keyword(s):  
Gene Family ◽  
Family Members ◽  
Secretory Vesicle ◽  
Vesicle Fusion

scholarly journals Isolation and Characterization of Rat Cytochrome P-450IIB Gene Family Members

1989 ◽  
Vol 264 (12) ◽  
pp. 7046-7053 ◽  
Author(s):  
C M Giachelli ◽  
J Lin-Jones ◽  
C J Omiecinski
Keyword(s):  
Gene Family ◽  
Family Members ◽  
Isolation And Characterization

scholarly journals Cloning and functional analysis of the FAD2 gene family from desert shrub Artemisia sphaerocephala

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiumei Miao ◽  
Lijing Zhang ◽  
Xiaowei Hu ◽  
Shuzhen Nan ◽  
Xiaolong Chen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Gene Family ◽  
Fatty Acid Biosynthesis ◽  
Family Members ◽  
Pcr Analysis ◽  
Mrna Levels ◽  
Acid Biosynthesis ◽  
Desert Shrub ◽  
Artemisia Sphaerocephala

Abstract Background Linoleic acid is an important polyunsaturated fatty acid, required for all eukaryotes. Microsomal delta-12 (Δ12) oleate desaturase (FAD2) is a key enzyme for linoleic acid biosynthesis. Desert shrub Artemisia sphaerocephala is rich in linoleic acid, it has a large FAD2 gene family with twenty-six members. The aim of this work is to unveil the difference and potentially functionality of AsFAD2 family members. Results Full-length cDNAs of twenty-one AsFAD2 genes were obtained from A. sphaerocephala. The putative polypeptides encoded by AsFAD2 family genes showed a high level of sequence similarity and were relatively conserved during evolution. The motif composition was also relatively conservative. Quantitative real-time PCR analysis revealed that the AsFAD2–1 gene was strongly expressed in developing seeds, which may be closely associated with the high accumulating ability of linoleic acid in A. sphaerocephala seeds. Although different AsFAD2 family members showed diverse response to salt stress, the overall mRNA levels of the AsFAD2 family genes was stable. Transient expression of AsFAD2 genes in the Nicotiana benthamiana leaves revealed that the encoded proteins were all located in the endoplasmic reticulum. Heterologous expression in Saccharomyces cerevisiae suggested that only three AsFAD2 enzymes, AsFAD2–1, − 10, and − 23, were Δ12 oleate desaturases, which could convert oleic acid to linoleic acid, whereas AsFAD2–1 and AsFAD2–10 could also produce palmitolinoleic acid. Conclusions This research reported the cloning, expression studies, subcellular localization and functional identification of the large AsFAD2 gene family. These results should be helpful in understanding fatty acid biosynthesis in A. sphaerocephala, and has the potential to be applied in the study of plant fatty acids traits.

Distinguishing CPT gene family members and vetting the sequence structure of a putative rubber synthesizing variant in Hevea brasiliensis

Gene ◽  
2019 ◽  
Vol 689 ◽  
pp. 183-193
Author(s):  
Thomas Kadampanattu Uthup ◽  
Anantharamanan Rajamani ◽  
Minimol Ravindran ◽  
Thakurdas Saha
Keyword(s):  
Gene Family ◽  
Hevea Brasiliensis ◽  
Family Members ◽  
Sequence Structure

scholarly journals Functional study of CHS gene family members in citrus revealed a novel CHS gene affecting the production of flavonoids

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Zhibin Wang ◽  
Qibin Yu ◽  
Wanxia Shen ◽  
Choaa A. El Mohtar ◽  
Xiaochun Zhao ◽  
...  
Keyword(s):  
Gene Family ◽  
Family Members ◽  
Functional Study

scholarly journals Avian apolipoprotein A-V binds to LDL receptor gene family members

2007 ◽  
Vol 48 (7) ◽  
pp. 1451-1456 ◽  
Author(s):  
Andrea Dichlberger ◽  
Larry A. Cogburn ◽  
Johannes Nimpf ◽  
Wolfgang J. Schneider
Keyword(s):  
Gene Family ◽  
Receptor Gene ◽  
Family Members ◽  
Ldl Receptor ◽  
Apolipoprotein A ◽  
Receptor Gene Family

Mapping of tyrosine kinase gene family members in aXiphophorus melanoma model

1998 ◽  
Vol 22 (3) ◽  
pp. 150-157 ◽  
Author(s):  
Donald C. Morizot ◽  
Brenda B. McEntire ◽  
Luis Della Coletta ◽  
Steven Kazianis ◽  
Manfred Schartl ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Gene Family ◽  
Family Members ◽  
Kinase Gene ◽  
Melanoma Model ◽  
Tyrosine Kinase Gene

scholarly journals Expression Profile and Prognostic Values of SMC Family Members in HCC

2021 ◽  
Author(s):  
Wei Yan ◽  
Dan-dan Wang ◽  
He-da Zhang ◽  
Jinny Huang ◽  
Jun-Chen Hou ◽  
...  
Keyword(s):  
Gene Family ◽  
Expression Profile ◽  
Proportional Hazards ◽  
Wide Spectrum ◽  
Clinical Stage ◽  
Family Members ◽  
Enrichment Analysis ◽  
Cox Proportional Hazards ◽  
Gene Set Enrichment Analysis ◽  
The Cancer Genome Atlas

Abstract Background: The structural maintenance of chromosome (SMC) gene family, comprising 6 members, is involved in a wide spectrum of biological functions in many types of human cancers. However, there is little research on the expression profile and prognostic values of SMC genes in hepatocellular carcinoma (HCC). Based on updated public resources and integrative bioinformatics analysis, we tried to determine the value of SMC gene expression in predicting the risk of developing HCC. Methods and materials: The expression data of SMC family members were obtained from The Cancer Genome Atlas (TCGA). The prognostic values of SMC members and clinical features were identified. A gene set enrichment analysis (GSEA) was conducted to explore the mechanism underlying the involvement of SMC members in liver cancer. The associations between tumor immune infiltrating cells (TIICs) and the SMC family members were evaluated using the Tumor Immune Estimation Resource (TIMER) database. Results: Our analysis demonstrated that mRNA downregulation of SMC genes was common alteration in HCC patients. SMC1A, SMC2, SMC3, SMC4, SMC6 were upregulated in HCC. Upregulation of SMC2, SMC3 and SMC4, along with clinical stage, were associated with a poor HCC prognosis based on the results of univariate and multivariate Cox proportional hazards regression analyses. SMC2, SMC3 and SMC4 are also related to tumor purity and immune infiltration levels of HCC. The GSEA results indicated that SMC members participate in multiple biological processes underlying tumorigenesis. Conclusion: This study comprehensively analyzed the expression of SMC gene family members in patients with HCC. This can provide insights for further investigation of the SMC family members as potential targets in HCC and suggest that the use of SMC inhibitor targeting SMC2, SMC3 and SMC4 may be an effective strategy for HCC therapy.

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