scholarly journals A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation

2016 ◽  
Vol 129 (16) ◽  
pp. 3167-3177 ◽  
Author(s):  
Simon Gemble ◽  
Géraldine Buhagiar-Labarchède ◽  
Rosine Onclercq-Delic ◽  
Denis Biard ◽  
Sarah Lambert ◽  
...  
Keyword(s):  
Anaphase Bridge ◽  
Bridge Formation

Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines

2005 ◽  
Vol 45 (3) ◽  
pp. 277-289 ◽  
Author(s):  
Juliet D. French ◽  
Jasmyn Dunn ◽  
Chanel E. Smart ◽  
Nathan Manning ◽  
Melissa A. Brown
Keyword(s):  
Cell Lines ◽  
Anaphase Bridge ◽  
Bridge Formation ◽  
Immortalized Cell Lines ◽  
Immortalized Cell ◽  
Telomere Lengthening

DNA repair pathways involved in anaphase bridge formation

2007 ◽  
Vol 46 (6) ◽  
pp. 522-531 ◽  
Author(s):  
Ceyda Acilan ◽  
Douglas M. Potter ◽  
William S. Saunders
Keyword(s):  
Dna Repair ◽  
Anaphase Bridge ◽  
Bridge Formation ◽  
Repair Pathways

Introductory Remarks

1980 ◽  
Vol 38 ◽  
pp. 598-599
Author(s):  
H. Mohri
Keyword(s):  
Muscle Contraction ◽  
Experimental Evidence ◽  
Sea Urchin ◽  
Constant Length ◽  
Thin Filaments ◽  
Bridge Formation ◽  
Thick Filaments ◽  
Sliding Mechanism ◽  
Radial Spokes ◽  
Cilia And Flagella

In 1959, Afzelius observed the presence of two rows of arms projecting from each outer doublet microtubule of the so-called 9 + 2 pattern of cilia and flagella, and suggested a possibility that the outer doublet microtubules slide with respect to each other with the aid of these arms during ciliary and flagellar movement. The identification of the arms as an ATPase, dynein, by Gibbons (1963)strengthened this hypothesis, since the ATPase-bearing heads of myosin molecules projecting from the thick filaments pull the thin filaments by cross-bridge formation during muscle contraction. The first experimental evidence for the sliding mechanism in cilia and flagella was obtained by examining the tip patterns of molluscan gill cilia by Satir (1965) who observed constant length of the microtubules during ciliary bending. Further evidence for the sliding-tubule mechanism was given by Summers and Gibbons (1971), using trypsin-treated axonemal fragments of sea urchin spermatozoa. Upon the addition of ATP, the outer doublets telescoped out from these fragments and the total length reached up to seven or more times that of the original fragment. Thus, the arms on a certain doublet microtubule can walk along the adjacent doublet when the doublet microtubules are disconnected by digestion of the interdoublet links which connect them with each other, or the radial spokes which connect them with the central pair-central sheath complex as illustrated in Fig. 1. On the basis of these pioneer works, the sliding-tubule mechanism has been established as one of the basic mechanisms for ciliary and flagellar movement.

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