scholarly journals Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila

2014 ◽  
Vol 127 (17) ◽  
pp. e1-e1
Author(s):  
L. T. Vuong ◽  
B. Mukhopadhyay ◽  
K.-W. Choi
Keyword(s):  
Wingless Signaling

scholarly journals Somatic mutations ofWNT/wingless signaling pathway components in primitive neuroectodermal tumors

2001 ◽  
Vol 93 (3) ◽  
pp. 445-449 ◽  
Author(s):  
Arend Koch ◽  
Anke Waha ◽  
J�rg C. Tonn ◽  
Nils S�rensen ◽  
Frank Berthold ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Somatic Mutations ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Wingless Signaling

scholarly journals The canonical Wingless signaling pathway is required but not sufficient for inflow tract formation in the Drosophila melanogaster heart

2016 ◽  
Vol 413 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Gloriana V. Trujillo ◽  
Dalea H. Nodal ◽  
Candice V. Lovato ◽  
Jill D. Hendren ◽  
Lynda A. Helander ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Signaling Pathway ◽  
Wingless Signaling

scholarly journals Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan

Development ◽  
2001 ◽  
Vol 128 (11) ◽  
pp. 2107-2117 ◽  
Author(s):  
Nicholas S. Tolwinski ◽  
Eric Wieschaus
Keyword(s):  
Drosophila Melanogaster ◽  
Plasma Membrane ◽  
Nuclear Import ◽  
Current Model ◽  
Cellular Distribution ◽  
Nuclear Retention ◽  
Binding Partners ◽  
Wingless Signaling ◽  
Anchoring System ◽  
Import And Export

Drosophila melanogaster Armadillo plays two distinct roles during development. It is a component of adherens junctions, and functions as a transcriptional activator in response to Wingless signaling. In the current model, Wingless signal causes stabilization of cytoplasmic Armadillo allowing it to enter the nucleus where it can activate transcription. However, the mechanism of nuclear import and export remains to be elucidated. In this study, we show that two gain-of-function alleles of Armadillo activate Wingless signaling by different mechanisms. The S10 allele was previously found to localize to the nucleus, where it activates transcription. In contrast, the ΔArm allele localizes to the plasma membrane, and forces endogenous Arm into the nucleus. Therefore, ΔArm is dependent on the presence of a functional endogenous allele of arm to activate transcription. We show that ΔArm may function by titrating Axin protein to the membrane, suggesting that it acts as a cytoplasmic anchor keeping Arm out of the nucleus. In axin mutants, Arm is localized to the nuclei. We find that nuclear retention is dependent on dTCF/Pangolin. This suggests that cellular distribution of Arm is controlled by an anchoring system, where various nuclear and cytoplasmic binding partners determine its localization.

scholarly journals Apical Localization of wingless Transcripts Is Required for Wingless Signaling

Cell ◽  
2001 ◽  
Vol 105 (2) ◽  
pp. 197-207 ◽  
Author(s):  
Andrew J. Simmonds ◽  
Gilbert dosSantos ◽  
Izhar Livne-Bar ◽  
Henry M. Krause
Keyword(s):  
Wingless Signaling ◽  
Apical Localization
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