scholarly journals TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages

2013 ◽  
Vol 126 (24) ◽  
pp. 5704-5713 ◽  
Author(s):  
Lin Gao ◽  
Tzong-jen Sheu ◽  
Yufeng Dong ◽  
Donna M. Hoak ◽  
Michael J. Zuscik ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Growth Plate ◽  
Sox9 Expression ◽  
Articular Cartilages

Microbiota‐derived lipopolysaccharide retards chondrocyte hypertrophy in the growth plate through elevating Sox9 expression

2018 ◽  
Vol 234 (3) ◽  
pp. 2593-2605 ◽  
Author(s):  
Xin Cheng ◽  
Pei‐Zhi Li ◽  
Guang Wang ◽  
Yu Yan ◽  
Ke Li ◽  
...  
Keyword(s):  
Growth Plate ◽  
Sox9 Expression ◽  
Chondrocyte Hypertrophy

Targeted Expression of SHH Affects Chondrocyte Differentiation, Growth Plate Organization, and Sox9 Expression

2004 ◽  
Vol 19 (10) ◽  
pp. 1678-1688 ◽  
Author(s):  
Sara Tavella ◽  
Roberta Biticchi ◽  
Anna Schito ◽  
Eleonora Minina ◽  
Davide Di Martino ◽  
...  
Keyword(s):  
Growth Plate ◽  
Chondrocyte Differentiation ◽  
Sox9 Expression ◽  
Targeted Expression

scholarly journals Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate

2002 ◽  
Vol 173 (3) ◽  
pp. 407-414 ◽  
Author(s):  
O Nilsson ◽  
V Abad ◽  
D Chrysis ◽  
EM Ritzen ◽  
L Savendahl ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Postnatal Development ◽  
Growth Plate ◽  
Estrogen Receptor Alpha ◽  
Proximal Tibia ◽  
Distal Humerus ◽  
Receptor Alpha ◽  
Hypertrophic Zone ◽  
Proliferative Zone ◽  
Epiphyseal Fusion

Estrogen regulates skeletal growth and promotes epiphyseal fusion. To explore the mechanisms underlying these effects we investigated the expression of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) in rat and rabbit growth plates during postnatal development, using immunohistochemistry. Immunoreactivity for ERalpha and ERbeta was observed in resting zone and proliferative zone chondrocytes at all ages studied for both rat (7, 14, 28 and 70 days of age) and rabbit (1, 7, 28 and 120 days of age). In the rat distal humerus and the rabbit proximal tibia, expression of both receptors in the hypertrophic zone was minimal at early ages, increasing only at the last time point prior to epiphyseal fusion. Expression was rarely seen in the hypertrophic zone of the rat proximal tibia, a growth plate that does not fuse until late in life. Therefore, we conclude that ERalpha and ERbeta are both expressed in the mammalian growth plate. The temporal and anatomical pattern suggests that ER expression in the hypertrophic zone in particular may play a role in epiphyseal fusion.

Effects of Hypophysectomy on the Occurrence and Calcifiability of Matrix Vesicles in the Epiphyseal Growth Plate of Immature Rats

1980 ◽  
Vol 38 ◽  
pp. 578-579
Author(s):  
S. I. Coleman ◽  
W. J. Dougherty
Keyword(s):  
Growth Plate ◽  
Matrix Vesicles ◽  
Epiphyseal Growth Plate ◽  
Hard Tissue ◽  
Hormonal Factors ◽  
Post Surgery ◽  
Mineral Deposition ◽  
Thin Sectioning ◽  
Integral Role ◽  
Cellular Secretion

In the cellular secretion theory of mineral deposition, extracellular matrix vesicles are believed to play an integral role in hard tissue mineralization (1). Membrane limited matrix vesicles arise from the plasma membrane of epiphyseal chondrocytes and tooth odontoblasts by a budding process (2, 3). Nutritional and hormonal factors have been postulated to play essential roles in mineral deposition and apparently have a direct effect on matrix vesicles of calcifying cartilage as concluded by Anderson and Sajdera (4). Immature (75-85 gm) Long-Evans hooded rats were hypophysectomized by the parapharyngeal approach and maintained fourteen (14) days post-surgery. At this time, the animals were anesthetized and perfusion fixed in cacodylate buffered 2.5% glutaraldehyde. The proximal tibias were quickly dissected out and split sagittally. One half was used for light microscopy (LM) and the other for electron microscopy (EM). The halves used for EM were cut into blocks approximately 1×3 mm. The tissue blocks were prepared for ultra-thin sectioning and transmission EM. The tissue was oriented so as to section through the epiphyseal growth plate from the zone of proliferating cartilage on down through the hypertrophic zone and into the initial trabecular bone. Sections were studied stained (double heavy metal) and unstained.

Continuous VA deficiency during postnatal development decreases rat learning and memory function via excitatory Ca2+neuron

2010 ◽  
Vol 34 (8) ◽  
pp. S18-S18
Author(s):  
Wei Jiang ◽  
Enyi Wen ◽  
Min Gong ◽  
Yang Bi ◽  
Xiaojuan Zhang ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Learning And Memory ◽  
Memory Function
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