scholarly journals The Tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3

2013 ◽  
Vol 126 (16) ◽  
pp. 3664-3677 ◽  
Author(s):  
M. Sabra ◽  
P. Texier ◽  
J. El Maalouf ◽  
P. Lomonte
Keyword(s):  
Motor Neuron ◽  
Binding Protein ◽  
Histone H3 ◽  
Survival Motor Neuron ◽  
Chromatin Binding ◽  
Methylated Lysine

Fugu rubripes and human survival motor neuron genes: Structural and functional similarities in comparative genome studies

Gene ◽  
2008 ◽  
Vol 424 (1-2) ◽  
pp. 108-114 ◽  
Author(s):  
Paramasivam Kathirvel ◽  
Wei-Ping Yu ◽  
Byrappa Venkatesh ◽  
Chui-Chin Lim ◽  
Poh-San Lai ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Survival Motor Neuron ◽  
Fugu Rubripes ◽  
Comparative Genome ◽  
Human Survival

scholarly journals The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival

Chromosoma ◽  
2021 ◽  
Author(s):  
Philipp A. Steffen ◽  
Christina Altmutter ◽  
Eva Dworschak ◽  
Sini Junttila ◽  
Attila Gyenesei ◽  
...  
Keyword(s):  
Transcriptional Profiling ◽  
Histone H3 ◽  
Chromatin Binding ◽  
Set Domain ◽  
Trithorax Group ◽  
Trxg Protein ◽  
Group Protein ◽  
Bah Domain ◽  
Mitotic Chromatin

AbstractThe Drosophila Trithorax group (TrxG) protein ASH1 remains associated with mitotic chromatin through mechanisms that are poorly understood. ASH1 dimethylates histone H3 at lysine 36 via its SET domain. Here, we identify domains of the TrxG protein ASH1 that are required for mitotic chromatin attachment in living Drosophila. Quantitative live imaging demonstrates that ASH1 requires AT hooks and the BAH domain but not the SET domain for full chromatin binding in metaphase, and that none of these domains are essential for interphase binding. Genetic experiments show that disruptions of the AT hooks and the BAH domain together, but not deletion of the SET domain alone, are lethal. Transcriptional profiling demonstrates that intact ASH1 AT hooks and the BAH domain are required to maintain expression levels of a specific set of genes, including several involved in cell identity and survival. This study identifies in vivo roles for specific ASH1 domains in mitotic binding, gene regulation, and survival that are distinct from its functions as a histone methyltransferase.

scholarly journals A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein

Cell Reports ◽  
2021 ◽  
Vol 35 (6) ◽  
pp. 109125
Author(s):  
Nikki M. McCormack ◽  
Mahlet B. Abera ◽  
Eveline S. Arnold ◽  
Rebecca M. Gibbs ◽  
Scott E. Martin ◽  
...  
Keyword(s):  
Motor Neuron ◽  
High Throughput ◽  
Rnai Screen ◽  
Survival Motor Neuron ◽  
Survival Motor Neuron Protein ◽  
Genome Wide ◽  
Motor Neuron Protein

scholarly journals Stabilization of the survival motor neuron protein by ASK1

FEBS Letters ◽  
2011 ◽  
Vol 585 (9) ◽  
pp. 1287-1292 ◽  
Author(s):  
Jeong Eun Kwon ◽  
Eun Kyung Kim ◽  
Eui-Ju Choi
Keyword(s):  
Motor Neuron ◽  
Survival Motor Neuron ◽  
Survival Motor Neuron Protein ◽  
Motor Neuron Protein
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