Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells

2012 ◽  
Vol 125 (22) ◽  
pp. 5280-5287 ◽  
Author(s):  
Asao Noda ◽  
Yuko Hirai ◽  
Kanya Hamasaki ◽  
Hiroshi Mitani ◽  
Nori Nakamura ◽  
...  
Keyword(s):  
Human Cells ◽  
Double Strand Breaks ◽  
Ionising Radiation ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Normal Human ◽  
Normal Human Cells

Wortmannin Inhibits Repair of DNA Double-Strand Breaks in Irradiated Normal Human Cells

1998 ◽  
Vol 149 (5) ◽  
pp. 440 ◽  
Author(s):  
Ryuichi Okayasu ◽  
Katsutoshi Suetomi ◽  
Robert L. Ullrich
Keyword(s):  
Human Cells ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Normal Human ◽  
Normal Human Cells

Age-dependent decline in rejoining of X-ray-induced DNA double-strand breaks in normal human lymphocytes

1989 ◽  
Vol 219 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Peter J. Mayer ◽  
Christopher S. Lange ◽  
Matthews O. Bradley ◽  
Warren W. Nichols
Keyword(s):  
Human Lymphocytes ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
X Ray ◽  
Age Dependent ◽  
Normal Human

Induction and Repair of DNA Double-Strand Breaks in Human Cells: Dephosphorylation of Histone H2AX and its Inhibition by Calyculin A

2005 ◽  
Vol 164 (4) ◽  
pp. 514-517 ◽  
Author(s):  
Francesca Antonelli ◽  
Mauro Belli ◽  
Giacomo Cuttone ◽  
Valentina Dini ◽  
Giuseppe Esposito ◽  
...  
Keyword(s):  
Human Cells ◽  
Double Strand Breaks ◽  
Calyculin A ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Histone H2ax

scholarly journals The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Lei Zhao ◽  
Chengyu Bao ◽  
Yuxuan Shang ◽  
Xinye He ◽  
Chiyuan Ma ◽  
...  
Keyword(s):  
Dna Repair ◽  
Double Strand Breaks ◽  
Ionising Radiation ◽  
Repair Pathway ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Dsb Repair ◽  
Strand Breaks ◽  
Dna Dsbs ◽  
Repair Pathways

Ionising radiation- (IR-) induced DNA double-strand breaks (DSBs) are considered to be the deleterious DNA lesions that pose a serious threat to genomic stability. The major DNA repair pathways, including classical nonhomologous end joining, homologous recombination, single-strand annealing, and alternative end joining, play critical roles in countering and eliciting IR-induced DSBs to ensure genome integrity. If the IR-induced DNA DSBs are not repaired correctly, the residual or incorrectly repaired DSBs can result in genomic instability that is associated with certain human diseases. Although many efforts have been made in investigating the major mechanisms of IR-induced DNA DSB repair, it is still unclear what determines the choices of IR-induced DNA DSB repair pathways. In this review, we discuss how the mechanisms of IR-induced DSB repair pathway choices can operate in irradiated cells. We first briefly describe the main mechanisms of the major DNA DSB repair pathways and the related key repair proteins. Based on our understanding of the characteristics of IR-induced DNA DSBs and the regulatory mechanisms of DSB repair pathways in irradiated cells and recent advances in this field, We then highlight the main factors and associated challenges to determine the IR-induced DSB repair pathway choices. We conclude that the type and distribution of IR-induced DSBs, chromatin state, DNA-end structure, and DNA-end resection are the main determinants of the choice of the IR-induced DNA DSB repair pathway.

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