scholarly journals p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors

2011 ◽  
Vol 124 (17) ◽  
pp. 3006-3016 ◽  
Author(s):  
Yusuke Sekine ◽  
Shuichi Takagahara ◽  
Ryo Hatanaka ◽  
Takeshi Watanabe ◽  
Haruka Oguchi ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Dopamine Synthesis ◽  
Expression Of Genes ◽  
P38 Mapks ◽  
Nr4a Nuclear Receptors

Abstract 191: Transcriptional Regulation of Renin by Nuclear Receptors Co-regulated With Renin

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Ko-Ting Lu ◽  
Eric T Weatherford ◽  
Pimonrat Ketsawatsomkron ◽  
Justin L Grobe ◽  
Curt D Sigmund
Keyword(s):  
Gene Expression ◽  
Nuclear Receptors ◽  
Estrogen Receptor Alpha ◽  
Hormone Receptors ◽  
Cell Types ◽  
Negative Control ◽  
Sirna Duplex ◽  
Expression Of Genes ◽  
Renin Gene ◽  
Genes Encoding

Expression of the renin gene is required to maintain normal morphological and physiological identity of renal juxtaglomerular (JG) cells, yet the mechanisms regulating renin gene transcription remain elusive. We re-examined data from Brunskill et. al (JASN 22:2213, 2011), investigating genome-wide gene expression in JG and other renal cell types. Based on our previous data implicating nuclear receptors (RAR, RXR, VDR, PPARG, Nr2f2 and Nr2f6) in the regulation of mouse and human renin gene expression, we focused our analysis on the expression of genes encoding the 48 nuclear hormone receptors and their co-regulation with renin. Several nuclear receptors have an expression pattern emulating that of renin, that is, they were similarly enriched in JG cells but not in other cell types. These include Esr1, Nr1h4, Ppara, VDR, Nr1i2, Ppard, Hnf4g, Nr1h3, Thrb, Hnf4a, Esrrg, Nr4a3, Nr3c2, and Ar. We tested the hypothesis that a nuclear receptor that is co-regulated with renin may participate in renin gene regulation. To accomplish this, endogenous renin expression was evaluated in renin-expressing As4.1 cells after siRNA-mediated knock down of selected nuclear receptors. Each experiment included a negative control siRNA duplex (NC) that does not target any known genes. By way of example, siRNA-mediated inhibition of estrogen receptor alpha (Esr1) by 70-80% resulted in a 2-fold decrease in renin mRNA (fold change ± SEM: siEsr1: 0.4±0.2, p<0.001 vs NC). Similar results were obtained with a different siRNA targeting Esr1. Interestingly, loss of Esr1 also caused up-regulation of vitamin D receptor (VDR, 2.8±0.7 fold, p<0.001 vs NC) and Nr2f6 (2.0±0.2 fold, p<0.05 vs NC), both of which are known to be negative regulators of renin. Similarly, both renin (0.1±0.02, p<0.001 vs untreated) and Esr1 (0.3±0.1, p<0.05 vs untreated) mRNA were reduced in the kidney from mice treated with deoxycorticosterone acetate (50mg) and receiving 0.15 M NaCl in drinking water for 21 days (DOCA-salt). These data suggest Esr1 may regulate renin expression. Studies are in progress to assess if Esr1 stimulates renin expression on its own or acts by affecting the level of other nuclear receptors; and to determine if other co-regulated nuclear receptors also regulate expression of the renin gene.

scholarly journals Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
S. Greg Call ◽  
Ryan P. Duren ◽  
Anil K. Panigrahi ◽  
Loc Nguyen ◽  
Pablo R. Freire ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Small Molecule ◽  
Nr4a Nuclear Receptors

Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease

2015 ◽  
Vol 129 (7) ◽  
pp. 589-599 ◽  
Author(s):  
Joaquin Perez-Schindler ◽  
Andrew Philp
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Nuclear Receptors ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Function ◽  
Metabolic Diseases ◽  
Therapeutic Potential ◽  
Muscle Metabolism ◽  
Cellular Level ◽  
Expression Of Genes

Skeletal muscle metabolism is highly dependent on mitochondrial function, with impaired mitochondrial biogenesis associated with the development of metabolic diseases such as insulin resistance and type 2 diabetes. Mitochondria display substantial plasticity in skeletal muscle, and are highly sensitive to levels of physical activity. It is thought that physical activity promotes mitochondrial biogenesis in skeletal muscle through increased expression of genes encoded in both the nuclear and the mitochondrial genome; however, how this process is co-ordinated at the cellular level is poorly understood. Nuclear receptors (NRs) are key signalling proteins capable of integrating environmental factors and mitochondrial function, thereby providing a potential link between exercise and mitochondrial biogenesis. The aim of this review is to highlight the function of NRs in skeletal muscle mitochondrial biogenesis and discuss the therapeutic potential of NRs for the management and treatment of chronic metabolic disease.

scholarly journals Decreased expression of NR4A nuclear receptors in adenomyosis impairs endometrial decidualization

2016 ◽  
Vol 22 (9) ◽  
pp. 655-668 ◽  
Author(s):  
Yue Jiang ◽  
Ruiwei Jiang ◽  
Xi Cheng ◽  
Qun Zhang ◽  
Yali Hu ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Nr4a Nuclear Receptors

scholarly journals Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia

Leukemia ◽  
2018 ◽  
Vol 33 (1) ◽  
pp. 52-63 ◽  
Author(s):  
Seth P. Boudreaux ◽  
Ryan P. Duren ◽  
Steven G. Call ◽  
Loc Nguyen ◽  
Pablo R. Freire ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Nuclear Receptors ◽  
Drug Targeting ◽  
Myeloid Leukemia ◽  
Acute Myeloid ◽  
Nr4a Nuclear Receptors

scholarly journals NR4A nuclear receptors in cardiac remodeling and neurohormonal regulation

2019 ◽  
Vol 29 (8) ◽  
pp. 429-437 ◽  
Author(s):  
Lejla Medzikovic ◽  
Carlie J.M. de Vries ◽  
Vivian de Waard
Keyword(s):  
Nuclear Receptors ◽  
Cardiac Remodeling ◽  
Nr4a Nuclear Receptors

NR4A Nuclear Receptors in Atherosclerosis and Vein-Graft Disease

2007 ◽  
Vol 17 (3) ◽  
pp. 105-111 ◽  
Author(s):  
Peter I. Bonta ◽  
Thijs W.H. Pols ◽  
Carlie J.M. de Vries
Keyword(s):  
Nuclear Receptors ◽  
Vein Graft ◽  
Vein Graft Disease ◽  
Graft Disease ◽  
Nr4a Nuclear Receptors

scholarly journals Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Dawn Z Eichenfield ◽  
Ty Dale Troutman ◽  
Verena M Link ◽  
Michael T Lam ◽  
Han Cho ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Tissue Damage ◽  
Wound Repair ◽  
Macrophage Polarization ◽  
Expression Of Genes ◽  
Mouse Macrophages ◽  
Molecular Patterns ◽  
Damage Associated Molecular Patterns

Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, in vivo they encounter multiple signals that control their varied functions in homeostasis, immunity, and disease. Here, we identify roles of Rev-erb nuclear receptors in regulating responses of mouse macrophages to complex tissue damage signals and wound repair. Rather than reinforcing a specific program of macrophage polarization, Rev-erbs repress subsets of genes that are activated by TLR ligands, IL4, TGFβ, and damage-associated molecular patterns (DAMPS). Unexpectedly, a complex damage signal promotes co-localization of NF-κB, Smad3, and Nrf2 at Rev-erb-sensitive enhancers and drives expression of genes characteristic of multiple polarization states in the same cells. Rev-erb-sensitive enhancers thereby integrate multiple damage-activated signaling pathways to promote a wound repair phenotype.

The Drosophila nuclear receptors EcR and ERR jointly regulate the expression of genes involved in carbohydrate metabolism

2019 ◽  
Vol 112 ◽  
pp. 103184 ◽  
Author(s):  
Elena V. Kovalenko ◽  
Marina Yu Mazina ◽  
Aleksey N. Krasnov ◽  
Nadezhda E. Vorobyeva
Keyword(s):  
Carbohydrate Metabolism ◽  
Nuclear Receptors ◽  
Expression Of Genes
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