scholarly journals Nuclear factor- B signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells

2010 ◽  
Vol 123 (12) ◽  
pp. 2135-2143 ◽  
Author(s):  
N. Gavert ◽  
A. Ben-Shmuel ◽  
V. Lemmon ◽  
T. Brabletz ◽  
A. Ben-Ze'ev
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Nuclear Factor ◽  
Colon Cancer Cells ◽  
Factor B

scholarly journals Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells

2015 ◽  
Vol 10 (3) ◽  
pp. 1287-1292 ◽  
Author(s):  
XIAO-QIAN ZHAO ◽  
YI-FEI ZHANG ◽  
YI-FANG XIA ◽  
ZHONG-MEI ZHOU ◽  
YING-QING CAO
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Related Factor ◽  
Nuclear Factor ◽  
Drug Resistant ◽  
Colon Cancer Cells

scholarly journals α-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-κB Signaling in Colon Cancer Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Dongdong Sun ◽  
Weixing Shen ◽  
Feng Zhang ◽  
Huisen Fan ◽  
Jiani Tan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Nuclear Translocation ◽  
Cyclin B1 ◽  
New Drugs ◽  
Nuclear Factor ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Sw620 Cells

Colon cancer represents the third most common malignancy worldwide. New drugs with high efficaciousness and safety for the treatment of colon cancer are urgently needed in clinical context. Here, we were aimed to evaluate the antitumor activity of the natural compound α-hederin in human colon cancer cells. We treated SW620 cells with interleukin-6 (IL-6) in vitro to mimic the paracrine inflammatory microenvironment of tumor cells. α-Hederin concentration dependently reduced the viability of IL-6-stimulated SW620 cells. α-Hederin increased the number of IL-6-stimulated SW620 cells at the G2/M phase and reduced the mRNA and protein expression of cyclin B1 and CDK1. Moreover, α-hederin induced apoptosis and loss of mitochondrial membrane potential in IL-6-stimulated SW620 cells. α-Hederin downregulated Bcl-2 expression, upregulated Bax expression, and promoted cytochrome c release from mitochondria into cytoplasm. Additionally, α-hederin elevated the levels of cleaved-caspase-9, cleaved-caspase-3, and cleaved-PARP, but had little effects on the levels of cleaved-caspase-8. Moreover, α-hederin prevented the nuclear translocation of nuclear factor-κB (NF-κB) and reduced the phosphorylation of IκBα and IKKα, suggesting the blockade of NF-κB signaling. NF-κB inhibitor PDTC not only produced similar proapoptotic effects on IL-6-stimulated SW620 cells as α-hederin did, but also synergistically enhanced α-hederin’s proapoptotic effects. Furthermore, α-hederin inhibited the phosphorylation of ERK in IL-6-stimulated SW620 cells, which was involved in α-hederin blockade of NF-κB nuclear translocation. Altogether, α-hederin suppressed viability, induced G2/M cell cycle arrest, and stimulated mitochondrial and caspase-dependent apoptosis in colon cancer cells, which were associated with disruption of NF-κB and ERK pathways, suggesting α-hederin as a promising candidate for intervention of colon cancer.

Effect of the dietary compound fisetin on nuclear factor‐kappa B (NF‐κB) signaling in HT‐29 colon cancer cells

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Mi Ra Seon ◽  
Han Jin Cho ◽  
Il‐Jun Kang ◽  
Hye‐Mi Kim ◽  
Seung‐Kyoung Jeung ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Colon Cancer Cells ◽  
Nuclear Factor Kappa ◽  
Ht 29

Apoptotic effect of genistein on human colon cancer cells via inhibiting the nuclear factor-kappa B (NF-κB) pathway

Tumor Biology ◽  
2014 ◽  
Vol 35 (11) ◽  
pp. 11483-11488 ◽  
Author(s):  
Yi Luo ◽  
Sheng-xiang Wang ◽  
Ze-quan Zhou ◽  
Zheng Wang ◽  
Yan-gao Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Kappa B ◽  
Human Colon ◽  
Nuclear Factor ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Nuclear Factor Kappa ◽  
Apoptotic Effect ◽  
Human Colon Cancer Cells
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