scholarly journals The perennial organelle: assembly and disassembly of the primary cilium

2010 ◽  
Vol 123 (4) ◽  
pp. 511-518 ◽  
Author(s):  
E. S. Seeley ◽  
M. V. Nachury
Keyword(s):  
Primary Cilium ◽  
Organelle Assembly

Growth factors and the primary cilium in BALB/c 3T3 cells

1987 ◽  
Vol 45 ◽  
pp. 830-831
Author(s):  
R. W. Tucker ◽  
N. S. More ◽  
S. Jayaraman
Keyword(s):  
Growth Factors ◽  
Primary Cilium ◽  
Cultured Cells ◽  
Morphological Changes ◽  
Calcium Ionophore ◽  
Growth Stimulation ◽  
Calcium Ionophore A23187 ◽  
Ionophore A23187 ◽  
3T3 Cells ◽  
Microtubule Depolymerization

The mechanisms by which polypeptide growth factors Induce DNA synthesis in cultured cells is not understood, but morphological changes Induced by growth factors have been used as clues to Intracellular messengers responsible for growth stimulation. One such morphological change has been the transient disappearance of the primary cilium, a “9 + 0” cilium formed by the perinuclear centriole in interphase cells. Since calcium ionophore A23187 also produced both mitogenesis and ciliary changes, microtubule depolymerization might explain ciliary disappearance monitored by indirect immunofluorescence with anti-tubulin antibody. However, complete resorption and subsequent reformation of the primary cilium occurs at mitosis, and might also account for ciliary disappearance induced by growth factors. To settle this issue, we investigated the ultrastructure of the primary cilium using serial thin-section electron microscopy of quiescent BALB/c 3T3 cells before and after stimulation with serum.

scholarly journals A primary cilium in oligodendrocytes: a fine structure signal of repairs in thalamic Osmotic Demyelination Syndrome (ODS)

2021 ◽  
pp. 1-30
Author(s):  
Jacques Gilloteaux ◽  
Joanna Bouchat ◽  
Valery Bielarz ◽  
Jean-Pierre Brion ◽  
Charles Nicaise
Keyword(s):  
Fine Structure ◽  
Primary Cilium ◽  
Osmotic Demyelination Syndrome ◽  
Osmotic Demyelination

Shear stress-induced Ca2+ mobilization in MDCK cells is ATP dependent, no matter the primary cilium

Cell Calcium ◽  
2013 ◽  
Vol 53 (5-6) ◽  
pp. 327-337 ◽  
Author(s):  
Lise Rodat-Despoix ◽  
Jizhe Hao ◽  
Mathieu Dandonneau ◽  
Patrick Delmas
Keyword(s):  
Shear Stress ◽  
Primary Cilium ◽  
Mdck Cells
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