scholarly journals KDP-1 is a nuclear envelope KASH protein required for cell-cycle progression

2009 ◽  
Vol 122 (16) ◽  
pp. 2895-2905 ◽  
Author(s):  
M. D. McGee ◽  
I. Stagljar ◽  
D. A. Starr
Keyword(s):  
Cell Cycle ◽  
Nuclear Envelope ◽  
Cell Cycle Progression ◽  
Cycle Progression

scholarly journals Lamin B1 Polymorphism Influences Morphology of the Nuclear Envelope, Cell Cycle Progression, and Risk of Neural Tube Defects in Mice

PLoS Genetics ◽  
2012 ◽  
Vol 8 (11) ◽  
pp. e1003059 ◽  
Author(s):  
Sandra C. P. De Castro ◽  
Ashraf Malhas ◽  
Kit-Yi Leung ◽  
Peter Gustavsson ◽  
David J. Vaux ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nuclear Envelope ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Lamin B1

scholarly journals Spatial control of nucleoporin assembly by Fragile X-related proteins

2019 ◽  
Author(s):  
Arantxa Agote-Arán ◽  
Stephane Schmucker ◽  
Katerina Jerabkova ◽  
Inès Jmel Boyer ◽  
Alessandro Berto ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nuclear Envelope ◽  
Fragile X Syndrome ◽  
Cell Cycle Progression ◽  
Fragile X ◽  
Nuclear Pore ◽  
Nuclear Morphology ◽  
Nuclear Pore Complexes ◽  
Cycle Progression ◽  
Pore Complexes

SummaryNucleoporins (Nups) build highly organized Nuclear Pore Complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs to regulate nucleocytoplasmic exchange. In the cytoplasm, a large excess of soluble Nups has been reported, but how their assembly is restricted to the NE is currently unknown. Here we show that Fragile X-related protein 1 (FXR1) can interact with several Nups and facilitate their localization to the NE during interphase through a microtubule and dynein-dependent mechanism. Downregulation of FXR1 or closely related orthologs FXR2 and Fragile X mental retardation protein (FMRP) leads to the accumulation of cytoplasmic Nup protein condensates. Likewise, several models of Fragile X syndrome (FXS), characterized by a loss of FMRP, also accumulate cytoplasmic Nup aggregates. These aggregate-containing cells display aberrant nuclear morphology and a delay in G1 cell cycle progression. Our results reveal an unexpected role for the FXR protein family and dynein in the spatial regulation of nucleoporin assembly.HighlightsCytoplasmic nucleoporins are assembled by Fragile X-related (FXR) proteins and dyneinFXR-Dynein pathway downregulation induces aberrant cytoplasmic aggregation of nucleoporinsCellular models of Fragile X syndrome accumulate aberrant cytoplasmic nucleoporin aggregates.FXR-Dynein pathway regulates nuclear morphology and G1 cell cycle progressioneTOC BlurbNucleoporins (Nups) form Nuclear Pore Complexes (NPCs) at the nuclear envelope. Agote-Arán at al. show how cells inhibit aberrant assembly of Nups in the cytoplasm and identify Fragile X-related (FXR) proteins and dynein that facilitate localization of Nups to the nuclear envelope and control G1 cell cycle progression.Graphical abstract

LAP1 is a crucial protein for the maintenance of the nuclear envelope structure and cell cycle progression

2014 ◽  
Vol 399 (1-2) ◽  
pp. 143-153 ◽  
Author(s):  
Mariana Santos ◽  
Patrícia Costa ◽  
Filipa Martins ◽  
Edgar F. da Cruz e Silva ◽  
Odete A. B. da Cruz e Silva ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nuclear Envelope ◽  
Cell Cycle Progression ◽  
Cycle Progression

scholarly journals Centripetal nuclear shape fluctuations associate with chromatin condensation towards mitosis

2021 ◽  
Author(s):  
Viola Introini ◽  
Gururaj Rao Kidiyoor ◽  
Giancarlo Porcella ◽  
Marco Foiani ◽  
Pietro Cicuta ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nuclear Envelope ◽  
Cell Cycle Progression ◽  
Chromatin Condensation ◽  
Nuclear Shape ◽  
Cycle Progression ◽  
Cellular Processes ◽  
Nuclear Envelope Breakdown ◽  
Nuclear Mechanics ◽  
Nuclear Processes

The cell nucleus plays a central role in several key cellular processes, including chromosome organisation, replication and transcription. Recent work intriguingly suggests an association between nuclear mechanics and cell-cycle progression, but many aspects of this connection remain unexplored. Here, by monitoring nuclear shape fluctuations at different cell cycle stages, we uncover increasing inward fluctuations in late G2 and early mitosis, which are initially transient, but develop into instabilities that culminate into nuclear-envelope breakdown in mitosis. Perturbation experiments and correlation analysis reveal an association of these processes with chromatin condensation. We propose that the contrasting forces between an extensile stress and centripetal pulling from chromatin condensation could link mechanically chromosome condensation and nuclear-envelope breakdown, the two main nuclear processes during mitosis.

scholarly journals Nuclear envelope influences on cell-cycle progression

2011 ◽  
Vol 39 (6) ◽  
pp. 1742-1746 ◽  
Author(s):  
Vlastimil Srsen ◽  
Nadia Korfali ◽  
Eric C. Schirmer
Keyword(s):  
Cell Cycle ◽  
Nuclear Envelope ◽  
Cell Cycle Progression ◽  
Membrane System ◽  
Regulatory Proteins ◽  
Cycle Progression ◽  
Cytoplasmic Surface ◽  
Dynamic Interface ◽  
Gene Regulatory ◽  
Cycle Regulation

The nuclear envelope is a complex double membrane system that serves as a dynamic interface between the nuclear and cytoplasmic compartments. Among its many roles is to provide an anchor for gene regulatory proteins on its nucleoplasmic surface and for the cytoskeleton on its cytoplasmic surface. Both sets of anchors are proteins called NETs (nuclear envelope transmembrane proteins), embedded respectively in the inner or outer nuclear membranes. Several lines of evidence indicate that the nuclear envelope contributes to cell-cycle regulation. These contributions come from both inner and outer nuclear membrane NETs and appear to operate through several distinct mechanisms ranging from sequestration of gene-regulatory proteins to activating kinase cascades.

scholarly journals Nuclear envelope deformation controls cell cycle progression in response to mechanical force

EMBO Reports ◽  
2019 ◽  
Vol 20 (9) ◽  
Author(s):  
Julien Aureille ◽  
Valentin Buffière‐Ribot ◽  
Ben E Harvey ◽  
Cyril Boyault ◽  
Lydia Pernet ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nuclear Envelope ◽  
Cell Cycle Progression ◽  
Mechanical Force ◽  
Cycle Progression
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