scholarly journals Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation

2009 ◽  
Vol 122 (9) ◽  
pp. 1322-1333 ◽  
Author(s):  
L. Formigli ◽  
C. Sassoli ◽  
R. Squecco ◽  
F. Bini ◽  
M. Martinesi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Muscle Differentiation ◽  
Skeletal Muscle Differentiation ◽  
C2c12 Myoblasts ◽  
Transient Receptor Potential Canonical ◽  
Sphingosine 1 Phosphate ◽  
Transient Receptor

scholarly journals Examining the role of transient receptor potential canonical 5 (TRPC5) in osteoarthritis

2020 ◽  
Vol 2 (4) ◽  
pp. 100119
Author(s):  
João de Sousa Valente ◽  
Khadija M. Alawi ◽  
Patrik Keringer ◽  
Sabah Bharde ◽  
Faseeha Ayaz ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Canonical ◽  
Transient Receptor

scholarly journals Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Qian Wang ◽  
Xuefei Tian ◽  
Yuyang Wang ◽  
Yan Wang ◽  
Jialin Li ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Actin Cytoskeleton ◽  
Diabetic Kidney Disease ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Diabetic Kidney ◽  
Transient Receptor Potential Canonical ◽  
Transient Receptor ◽  
Cytoskeleton Rearrangement

Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed to be the key process resulting in glomerular injury. Many studies have recently shown that transient receptor potential canonical channel 6 (TRPC6) in podocyte plays a critical role in the development and progression of proteinuric kidney disease by regulating its actin cytoskeleton rearrangement. This review is aimed at summarizing the role of TRPC6 on DKD by regulating the podocyte actin cytoskeleton rearrangement, thereby help further broaden our views and understanding on the mechanism of DKD and provide a theoretic basis for exploring new therapeutic targets for DKD patients.

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