scholarly journals Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment

2008 ◽  
Vol 121 (18) ◽  
pp. 3042-3051 ◽  
Author(s):  
A. Corradi ◽  
A. Zanardi ◽  
C. Giacomini ◽  
F. Onofri ◽  
F. Valtorta ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Synapsin I ◽  
Synapsin Ii ◽  
Age Dependent

scholarly journals Age-Dependent Association Between Elevated Homocysteine and Cognitive Impairment in a Post-stroke Population: A Prospective Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Shengnan Zhou ◽  
Jiahao Chen ◽  
Lin Cheng ◽  
Kaili Fan ◽  
Minjie Xu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Multivariate Regression Analysis ◽  
Logistic Regression Models ◽  
Post Stroke ◽  
Stroke Population ◽  
Age Dependent ◽  
Independent Association ◽  
A Prospective Study ◽  
State Examination

Background and Purpose: The results regarding the independent association between homocysteine (Hcy) levels and post-stroke cognitive impairment (PSCI) were inconsistent. The effect of age on this association has yet to be explored. This study aims to determine the relationship between Hcy levels, age, and cognitive impairment in a post-stroke population.Methods: A total of 592 patients with acute ischemic stroke (AIS) completed follow-up. Serum Hcy levels were measured enzymatically by spectrophotometry within 24 h of admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) 1 month after stroke, and the scores ≤ 24 were considered as cognitive impairment. Our study was dichotomized into two groups by a cut-off of 65 years. Multivariate logistic regression models were used to determine the association between baseline Hcy levels and cognitive impairment.Results: According to the MMSE score, 317 (53.5%) patients had cognitive impairment. Patients with higher levels of Hcy were more prone to have cognitive impairment 1 month after stroke than patients with lower levels of Hcy (p < 0.001). The optimal cut-off points of Hcy level (μmol/L) were (T1) ≤ 8, (T2) 8–12, and (T3) ≥ 12. After adjusting for confounding factors, the multivariate regression analysis showed that the third Hcy tertile was independently associated with cognitive impairment [odds ratio (OR) = 2.057, 95% confidence interval (CI) = 1.133–3.735, p = 0.018). A stronger association [T2 (OR = 2.266, 95% CI = 1.042–4.926, p = 0.039); T3 (OR =3.583, 95% CI = 1.456–8.818, p = 0.005)] was found in the younger group. However, the independent association was not confirmed in the older group.Conclusions: Elevated Hcy levels in the acute phase of ischemic stroke were independently associated with cognitive impairment in a post-stroke population. Furthermore, the association was age-dependent and more meaningful in a younger population aged below 65. So, Hcy levels in patients with stroke should be well-monitored, especially in younger patients.

scholarly journals Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue

2009 ◽  
Vol 11 (3) ◽  
pp. 347-362 ◽  
Author(s):  
Catherine H. Choi ◽  
Sean M. J. McBride ◽  
Brian P. Schoenfeld ◽  
David A. Liebelt ◽  
David Ferreiro ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Fragile X ◽  
Age Dependent

scholarly journals Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

1998 ◽  
Vol 4 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Adriana Ferreira ◽  
Lih-Shen Chin ◽  
Lian Li ◽  
Lorene M. Lanier ◽  
Kenneth S. Kosik ◽  
...  
Keyword(s):  
Neuronal Development ◽  
Synapsin I ◽  
Synapsin Ii

P3-209: COGNITIVE IMPAIRMENT IS ASSOCIATED WITH PREMATURE ARTERIAL STIFFENING, AORTIC WALL FIBROSIS AND INCREASED BLOOD PRESSURE: A NOVEL RAT MODEL OF AGE-DEPENDENT VASCULAR DEMENTIA

2006 ◽  
Vol 14 (7S_Part_21) ◽  
pp. P1149-P1150
Author(s):  
Olga V. Fedorova ◽  
Yulia Grigorova ◽  
Madeleine Hagood ◽  
Jeffrey Long ◽  
Ross McDevitt ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
Vascular Dementia ◽  
Rat Model ◽  
Aortic Wall ◽  
Arterial Stiffening ◽  
Age Dependent

ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment

2021 ◽  
Vol 143 ◽  
pp. 292-301
Author(s):  
Jing Zhang ◽  
Lanyan Lin ◽  
Xiaoman Dai ◽  
Nai'an Xiao ◽  
Qinyong Ye ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Age Dependent
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