scholarly journals Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells

2005 ◽  
Vol 118 (13) ◽  
pp. 2849-2858 ◽  
Author(s):  
A.-M. Marzesco
Keyword(s):  
Stem Cell ◽  
Epithelial Cells ◽  
Neural Progenitors ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Membrane Particles

scholarly journals Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1

2007 ◽  
Vol 176 (4) ◽  
pp. 483-495 ◽  
Author(s):  
Véronique Dubreuil ◽  
Anne-Marie Marzesco ◽  
Denis Corbeil ◽  
Wieland B. Huttner ◽  
Michaela Wilsch-Bräuninger
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Primary Cilium ◽  
Neural Progenitors ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Membrane Particles ◽  
Membrane Microdomain ◽  
Neuroepithelial Cells ◽  
Stem And Progenitor Cells

Expansion of the neocortex requires symmetric divisions of neuroepithelial cells, the primary progenitor cells of the developing mammalian central nervous system. Symmetrically dividing neuroepithelial cells are known to form a midbody at their apical (rather than lateral) surface. We show that apical midbodies of neuroepithelial cells concentrate prominin-1 (CD133), a somatic stem cell marker and defining constituent of a specific plasma membrane microdomain. Moreover, these apical midbodies are released, as a whole or in part, into the extracellular space, yielding the prominin-1–enriched membrane particles found in the neural tube fluid. The primary cilium of neuroepithelial cells also concentrates prominin-1 and appears to be a second source of the prominin-1–bearing extracellular membrane particles. Our data reveal novel origins of extracellular membrane traffic that enable neural stem and progenitor cells to avoid the asymmetric inheritance of the midbody observed for other cells and, by releasing a stem cell membrane microdomain, to potentially influence the balance of their proliferation versus differentiation.

Human Corneal Basal Epithelial Cells Express an Embryonic Stem Cell Marker OCT4

2010 ◽  
Vol 35 (11) ◽  
pp. 978-985 ◽  
Author(s):  
Shi-you Zhou ◽  
Cheng Zhang ◽  
Ebrahimi Baradaran ◽  
Roy S. Chuck
Keyword(s):  
Stem Cell ◽  
Epithelial Cells ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Basal Epithelial Cells

The Corneal Epithelial Stem Cell Marker - Novel Combination of High Expression of p63 and a Large N/C Ratio

2008 ◽  
Vol 1 (3) ◽  
pp. 95-105
Author(s):  
Arpitha P. ◽  
Prajna N. V. ◽  
Srinivasan M. ◽  
Muthukkaruppan V. R.
Keyword(s):  
Stem Cell ◽  
High Expression ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Corneal Epithelial ◽  
Epithelial Stem Cell ◽  
Large N
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