scholarly journals Changing chromatin dynamics and nuclear organization during differentiation in Drosophila larval tissue

2005 ◽  
Vol 118 (5) ◽  
pp. 951-960 ◽  
Author(s):  
R. Thakar
Keyword(s):  
Nuclear Organization ◽  
Chromatin Dynamics ◽  
Larval Tissue

Impact of a selfish B chromosome on chromatin dynamics and nuclear organization in Nasonia

2012 ◽  
Vol 125 (21) ◽  
pp. 5241-5249 ◽  
Author(s):  
M. M. Swim ◽  
K. E. Kaeding ◽  
P. M. Ferree
Keyword(s):  
Nuclear Organization ◽  
B Chromosome ◽  
Chromatin Dynamics

Nuclear organization and chromatin dynamics in yeast: Biophysical models or biologically driven interactions?

2012 ◽  
Vol 1819 (6) ◽  
pp. 468-481 ◽  
Author(s):  
Benjamin Albert ◽  
Isabelle Léger-Silvestre ◽  
Christophe Normand ◽  
Olivier Gadal
Keyword(s):  
Nuclear Organization ◽  
Chromatin Dynamics ◽  
Biophysical Models

Nuclear organization and chromatin dynamics – Sp1, Sp3 and histone deacetylases

2008 ◽  
Vol 48 (1) ◽  
pp. 189-208 ◽  
Author(s):  
James R. Davie ◽  
Shihua He ◽  
Lin Li ◽  
Anoushe Sekhavat ◽  
Paula Espino ◽  
...  
Keyword(s):  
Histone Deacetylases ◽  
Nuclear Organization ◽  
Chromatin Dynamics

Quantitative Model-Based Image Analysis of NuMa Distribution Links Nuclear Organization with Cell Phenotype

2001 ◽  
Vol 7 (S2) ◽  
pp. 578-579
Author(s):  
David W. Knowles ◽  
Sophie A. Lelièvre ◽  
Carlos Ortiz de Solόrzano ◽  
Stephen J. Lockett ◽  
Mina J. Bissell ◽  
...  
Keyword(s):  
Image Analysis ◽  
Mammary Epithelial Cells ◽  
Nuclear Organization ◽  
Critical Role ◽  
Quantitative Model ◽  
Mammary Epithelial ◽  
Cell Phenotype ◽  
Proliferating Cells ◽  
Mitotic Apparatus ◽  
Model Based

The extracellular matrix (ECM) plays a critical role in directing cell behaviour and morphogenesis by regulating gene expression and nuclear organization. Using non-malignant (S1) human mammary epithelial cells (HMECs), it was previously shown that ECM-induced morphogenesis is accompanied by the redistribution of nuclear mitotic apparatus (NuMA) protein from a diffuse pattern in proliferating cells, to a multi-focal pattern as HMECs growth arrested and completed morphogenesis . A process taking 10 to 14 days.To further investigate the link between NuMA distribution and the growth stage of HMECs, we have investigated the distribution of NuMA in non-malignant S1 cells and their malignant, T4, counter-part using a novel model-based image analysis technique. This technique, based on a multi-scale Gaussian blur analysis (Figure 1), quantifies the size of punctate features in an image. Cells were cultured in the presence and absence of a reconstituted basement membrane (rBM) and imaged in 3D using confocal microscopy, for fluorescently labeled monoclonal antibodies to NuMA (fαNuMA) and fluorescently labeled total DNA.

Chromatin dynamics and DNA repair

10.2741/1013 ◽  
2003 ◽  
Vol 8 (6) ◽  
pp. s149-155 ◽  
Author(s):  
Vasily V Ogryzko
Keyword(s):  
Dna Repair ◽  
Chromatin Dynamics
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