scholarly journals Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition

2004 ◽  
Vol 117 (25) ◽  
pp. 6175-6183 ◽  
Author(s):  
T. Jordan
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fibers ◽  
Slow Muscle ◽  
Muscle Fiber Type ◽  
Fast Skeletal Muscle ◽  
Type Transition ◽  
Ryanodine Receptor 1

scholarly journals Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway

2019 ◽  
Vol 10 (6) ◽  
pp. 3334-3343 ◽  
Author(s):  
Qinyang Jiang ◽  
Xiaofang Cheng ◽  
Yueyue Cui ◽  
Qin Xia ◽  
Xueyu Yan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fibers ◽  
Underlying Mechanism ◽  
Skeletal Muscle Fiber ◽  
Muscle Fiber Type ◽  
Skeletal Muscle Fibers

This study was conducted to investigate the effect and underlying mechanism of Resveratrol (RES) in regulating skeletal muscle fiber-type switching.

Quercetin regulates skeletal muscle fiber type switching via adiponectin signaling

2021 ◽  
Author(s):  
Xiaoling Chen ◽  
Dahui Liang ◽  
Zhiqing Huang ◽  
Gang Jia ◽  
Hua Zhao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Molecular Mechanism ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Skeletal Muscle Fiber ◽  
Muscle Fiber Type ◽  
Type Transition

This study aimed to investigate the role and underlying molecular mechanism of quercetin in regulating skeletal muscle fiber type transition. We found that dietary quercetin supplementation in mice significantly increased...

The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity

Development ◽  
2000 ◽  
Vol 127 (10) ◽  
pp. 2189-2199 ◽  
Author(s):  
M.J. Barresi ◽  
H.L. Stickney ◽  
S.H. Devoto
Keyword(s):  
Muscle Fiber ◽  
Hedgehog Signaling ◽  
Fiber Type ◽  
Muscle Fibers ◽  
Muscle Cells ◽  
Fiber Development ◽  
Slow Muscle ◽  
Dominant Negative ◽  
Muscle Fiber Type ◽  
Wild Type

Hedgehog proteins mediate many of the inductive interactions that determine cell fate during embryonic development. Hedgehog signaling has been shown to regulate slow muscle fiber type development. We report here that mutations in the zebrafish slow-muscle-omitted (smu) gene disrupt many developmental processes involving Hedgehog signaling. smu(−/−) embryos have a 99% reduction in the number of slow muscle fibers and a complete loss of Engrailed-expressing muscle pioneers. In addition, mutant embryos have partial cyclopia, and defects in jaw cartilage, circulation and fin growth. The smu(−/−) phenotype is phenocopied by treatment of wild-type embryos with forskolin, which inhibits the response of cells to Hedgehog signaling by indirect activation of cAMP-dependent protein kinase (PKA). Overexpression of Sonic hedgehog (Shh) or dominant negative PKA (dnPKA) in wild-type embryos causes all somitic cells to develop into slow muscle fibers. Overexpression of Shh does not rescue slow muscle fiber development in smu(−/−) embryos, whereas overexpression of dnPKA does. Cell transplantation experiments confirm that smu function is required cell-autonomously within the muscle precursors: wild-type muscle cells rescue slow muscle fiber development in smu(−/−) embryos, whereas mutant muscle cells cannot develop into slow muscle fibers in wild-type embryos. Slow muscle fiber development in smu mutant embryos is also rescued by expression of rat Smoothened. Therefore, Hedgehog signaling through Slow-muscle-omitted is necessary for slow muscle fiber type development. We propose that smu encodes a vital component in the Hedgehog response pathway.

scholarly journals Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Silvia Giannattasio ◽  
Giacomo Giacovazzo ◽  
Agnese Bonato ◽  
Carla Caruso ◽  
Siro Luvisetto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Endurance Performance ◽  
Skeletal Muscle Fiber ◽  
Muscle Fiber Type ◽  
Cyclin D3 ◽  
Type Shifting
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