scholarly journals Coordination of cell growth and cell division: a mathematical modeling study

2004 ◽  
Vol 117 (18) ◽  
pp. 4199-4207 ◽  
Author(s):  
Z. Qu
Keyword(s):  
Mathematical Modeling ◽  
Cell Division ◽  
Cell Growth ◽  
Modeling Study

scholarly journals Evaluation of work resumption strategies after COVID-19 reopening in the Chinese city of Shenzhen: a mathematical modeling study

Public Health ◽  
2021 ◽  
Author(s):  
Lu Bai ◽  
Haonan Lu ◽  
Hailin Hu ◽  
M. Kumi Smith ◽  
Katherine Harripersaud ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Chinese City ◽  
Work Resumption ◽  
Modeling Study

Relations between cell growth and cell division

1961 ◽  
Vol 23 (2) ◽  
pp. 354-360 ◽  
Author(s):  
I.L. Cameron ◽  
D.M. Prescott
Keyword(s):  
Cell Division ◽  
Cell Growth

Mathematical modeling of cell growth in a 3D scaffold and validation of static and dynamic cultures

2016 ◽  
Vol 16 (3) ◽  
pp. 290-298 ◽  
Author(s):  
Fatemeh Mokhtari-Jafari ◽  
Ghassem Amoabediny ◽  
Nooshin Haghighipour ◽  
Reza Zarghami ◽  
Alireza Saatchi ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Cell Growth ◽  
3D Scaffold

scholarly journals Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division

2018 ◽  
Author(s):  
Evgeny Zatulovskiy ◽  
Daniel F. Berenson ◽  
Benjamin R. Topacio ◽  
Jan M. Skotheim
Keyword(s):  
Cell Cycle ◽  
Cell Division ◽  
Cell Growth ◽  
Cell Size ◽  
Mammalian Cells ◽  
Molecular Mechanisms ◽  
Inverse Correlation ◽  
Cell Types ◽  
Similar Amount ◽  
Cell Cycle Inhibitor

Cell size is fundamental to function in different cell types across the human body because it sets the scale of organelle structures, biosynthesis, and surface transport1,2. Tiny erythrocytes squeeze through capillaries to transport oxygen, while the million-fold larger oocyte divides without growth to form the ~100 cell pre-implantation embryo. Despite the vast size range across cell types, cells of a given type are typically uniform in size likely because cells are able to accurately couple cell growth to division3–6. While some genes whose disruption in mammalian cells affects cell size have been identified, the molecular mechanisms through which cell growth drives cell division have remained elusive7–12. Here, we show that cell growth acts to dilute the cell cycle inhibitor Rb to drive cell cycle progression from G1 to S phase in human cells. In contrast, other G1/S regulators remained at nearly constant concentration. Rb is a stable protein that is synthesized during S and G2 phases in an amount that is independent of cell size. Equal partitioning to daughter cells of chromatin bound Rb then ensures that all cells at birth inherit a similar amount of Rb protein. RB overexpression increased cell size in tissue culture and a mouse cancer model, while RB deletion decreased cell size and removed the inverse correlation between cell size at birth and the duration of G1 phase. Thus, Rb-dilution by cell growth in G1 provides a long-sought cell autonomous molecular mechanism for cell size homeostasis.

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