scholarly journals Nuclear RNA export

2003 ◽  
Vol 116 (4) ◽  
pp. 587-597 ◽  
Author(s):  
B. R. Cullen
Keyword(s):  
Nuclear Rna ◽  
Rna Export ◽  
Nuclear Rna Export

scholarly journals Mutational Definition of Functional Domains within the Rev Homolog Encoded by Human Endogenous Retrovirus K

2000 ◽  
Vol 74 (20) ◽  
pp. 9353-9361 ◽  
Author(s):  
Hal P. Bogerd ◽  
Heather L. Wiegand ◽  
Jin Yang ◽  
Bryan R. Cullen
Keyword(s):  
Nuclear Export ◽  
Biological Activities ◽  
Endogenous Retrovirus ◽  
Viral Rna ◽  
Human Endogenous Retrovirus ◽  
Nuclear Rna ◽  
Rna Export ◽  
Nuclear Rna Export ◽  
Hiv 1 ◽  
Rev Protein

ABSTRACT Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related to the exogenous retrovirus HIV-1, was recently shown to also encode a Crm1-dependent nuclear RNA export factor, termed K-Rev. Although HIV-1 Rev and K-Rev display little sequence identity, they share the ability not only to bind to Crm1 and to RNA but also to form homomultimers and shuttle between nucleus and cytoplasm. We have used mutational analysis to identify sequences in the 105-amino-acid K-Rev protein required for each of these distinct biological activities. While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export. Although several nonfunctional K-Rev mutants acted as dominant negative inhibitors of K-Rev-, but not HIV-1 Rev-, dependent RNA export, these were not defined by their inability to bind to Crm1, as is seen with HIV-1 Rev. In total, this analysis suggests a functional architecture for K-Rev that is similar to, but distinct from, that described for HIV-1 Rev and raises the possibility that viral RNA export mediated by the ∼25 million-year-old K-Rev protein may require an additional cellular cofactor that is not required for HIV-1 Rev function.

scholarly journals 68P Deciphering the interplay between nuclear RNA export factors and long non-coding RNAs in breast cancer metabolism

2020 ◽  
Vol 31 ◽  
pp. S38
Author(s):  
C. Klec ◽  
D. Schwarzenbacher ◽  
B. Gottschalk ◽  
R. Margit ◽  
F. Prinz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Metabolism ◽  
Nuclear Rna ◽  
Rna Export ◽  
Non Coding Rnas ◽  
Nuclear Rna Export ◽  
Rna Export Factors

scholarly journals ExportAid: database of RNA elements regulating nuclear RNA export in mammals

2014 ◽  
Vol 31 (2) ◽  
pp. 246-251 ◽  
Author(s):  
M. Giulietti ◽  
S. A. Milantoni ◽  
T. Armeni ◽  
G. Principato ◽  
F. Piva
Keyword(s):  
Nuclear Rna ◽  
Rna Export ◽  
Rna Elements ◽  
Nuclear Rna Export

Nuclear RNA export: Possible role of an RNA unwindase activity

1990 ◽  
Vol 14 ◽  
pp. 128
Author(s):  
H SCHRODER ◽  
D UGARKOVIC ◽  
M BACHMANN ◽  
W MULLER
Keyword(s):  
Nuclear Rna ◽  
Rna Export ◽  
Nuclear Rna Export

scholarly journals NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation

2001 ◽  
Vol 11 (18) ◽  
pp. 1381-1391 ◽  
Author(s):  
Lin Jun ◽  
Suzanna Frints ◽  
Hein Duhamel ◽  
Andrea Herold ◽  
Jose Abad-Rodrigues ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Male Patient ◽  
Nuclear Rna ◽  
Rna Export ◽  
Nuclear Rna Export

Real-time quantification of nuclear RNA export using an intracellular relocation probe

2021 ◽  
Author(s):  
Jie Shen ◽  
Juan Chen ◽  
Dong Wang ◽  
Zhengjie Liu ◽  
Guangmei Han ◽  
...  
Keyword(s):  
Real Time ◽  
Nuclear Rna ◽  
Rna Export ◽  
Nuclear Rna Export

scholarly journals Nuclear RNA export in yeast

FEBS Letters ◽  
1999 ◽  
Vol 452 (1-2) ◽  
pp. 77-81 ◽  
Author(s):  
Katja Sträßer ◽  
Ed Hurt
Keyword(s):  
Nuclear Rna ◽  
Rna Export ◽  
Nuclear Rna Export
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