scholarly journals Role of beta3-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor

2002 ◽  
Vol 115 (20) ◽  
pp. 3879-3888 ◽  
Author(s):  
F. Besta
Keyword(s):  
Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Plasminogen Activator Receptor ◽  
Nf Kappab

Urokinase-type plasminogen activator receptor is associated with the development of adipose tissue

2010 ◽  
Vol 104 (12) ◽  
pp. 1124-1132 ◽  
Author(s):  
Hiroyuki Matsuno ◽  
Eri Kawashita ◽  
Kiyotaka Okada ◽  
Hidetaka Suga ◽  
Shigeru Ueshima ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Plasminogen Activator ◽  
Adipocyte Differentiation ◽  
Cellular Adhesion ◽  
Wild Type ◽  
Tissue Mass ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Plasminogen Activator Receptor

SummaryUrokinase-type plasminogen activator receptor (uPAR) plays a role in cellular responses which include cellular adhesion, differentiation, proliferation and migration. The aim of this study was to clarify the role of uPAR on the development of adipose tissue. To clarify the role of uPAR on adipogenesis, we examined the effect of uPAR overexpression and uPAR deficiency on the adipocyte differentiation. Adipocyte differentiation was induced by incubation of 3T3-L1 cells with differentiation media containing insulin, dexamethasone, and 1-methyl-3-isobutylxanthin. uPAR overexpression by transfection of uPAR expression vector induced adipocyte differentiation. In addition, we examined the difference in adipocyte differentiation of mesenchymal stem cells from wild-type mice and uPAR knockout (uPAR-/-) mice. The uPAR deficiency attenuated differentiation media-induced adipocyte differentiation. Moreover, we found that the inhibition of phosphatidylinositol 3-kinase (PI3K) pathway attenuated uPAR overexpression-induced adipocyte differentiation, and uPAR overexpression induced the activation of Akt. We also found that an increase of the adipose tissue mass in uPAR-/- mice was less than that observed in wild-type mice. The present results suggest that uPAR plays a pivotal role in the development of adipose tissue through PI3K/Akt pathway.

Proteolysis and invasiveness of brain tumors: Role of urokinase-type plasminogen activator receptor

1994 ◽  
Vol 22 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Sanjeeva Mohanam ◽  
Raymond E. Sawaya ◽  
Masaaki Yamamoto ◽  
Janet M. Bruner ◽  
Garth L. Nicholson ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Plasminogen Activator Receptor
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