scholarly journals Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis

2019 ◽  
Vol 12 (12) ◽  
pp. dmm040998 ◽  
Author(s):  
Yong Chen ◽  
Yuhki Koike ◽  
Lijun Chi ◽  
Abdalla Ahmed ◽  
Hiromu Miyake ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Formula Feeding ◽  
Intestinal Hypoxia

scholarly journals Enteral feeding strategy for newborns with necrotizing enterocolitis

2020 ◽  
Vol 18 (4) ◽  
pp. 17-28
Author(s):  
A.I. Aminova ◽  
◽  
P.A. Bobkova ◽  
E.I. Belova ◽  
N.V. Zaytseva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parenteral Nutrition ◽  
Necrotizing Enterocolitis ◽  
Enteral Feeding ◽  
Gestational Age ◽  
Reproductive Technologies ◽  
Formula Feeding ◽  
Study Objective ◽  
Maternal Risk ◽  
Group I

Study objective. To optimize the recommendations on the strategy of enteral feeding for newborn babies with necrotizing enterocolitis (NEC). Patients and methods. A single-centre, observational, prospective, analytical, cohort study of 186 infants aged from 2 days to 2 months (96 boys, 90 girls) with the verified diagnosis of NEC of varied severity, who were treated at the neonatal pathology department of Moscow G.N.Speransky Children’s City Clinical Hospital No 9 in 2016-2018. The patients were divided into 2 groups, depending on disease staging according to the Walsh and Kliegman classification: group I – 124 (66.7%) newborns with mild NEC (stage 1A, B and 2A) and group II – 62 (33.3%) patients with a severe course (stages 2B and 3A, B). Results. As has been found, maternal risk factors for the development of severe forms of NEC in newborns are: maternal age over 40 years (OR = 1.40, 95% CI 0.83–2.17), assisted reproductive technologies (OR = 2.62, 95% CI 1.79–3.66), bad obstetrical-gynaecological history (OR = 1.80, 95% CI 1.03–2.97), infectious diseases during pregnancy (OR = 1.37, 95% CI 0.69–1.90). The ranking of the risk factors present in babies themselves permitted to find a causative relation with such factors as bacteriological contamination of biological media (OR = 2.80, 95% CI 1.3–4.0), bacteremia, viremia (OR = 5.80, 95% CI 2.99–7.13), gestational age 30–32 wks (OR = 2.35, 95% CI 1.01–3.94), which were significant only for mild forms of NEC. A minimal number of severe cases was diagnosed for a combination of breastfeeding and parenteral nutrition (16.7%), development of severe NEC was more often noted when feeding was started within 5 days: breastfeeding (26.3%), formula feeding (33.3 %), mixed breast and formula feeding (5%), or in infants who did not receive feeding due to their severe condition after birth (33%) (р < 0.05). The minimal number of severe NEC cases was found among babies who remained on breast (11.1%) and mixed (11.1%) feeding after the 5th day (р < 0.05), the maximal number – in infants who started from enteral feeding and were transferred to formula feeding (50%). Prolonged enteral feeding was three times more often associated with a severe course of NEC (р < 0.001). Conclusion. As has been found, the frequency of developing severe NEC depends on the character of the first feed after birth. A risk of developing severe forms of NEC decreases in newborns on breast- or mixed feeding, in combination of breast feeding and parenteral nutrition, short courses of enteral pauses, alternation of enteral feeding and enteral pauses. The results might be used in the clinical practice of neonatologists and paediatricians for prevention and management of NEC and its possible complications in newborn infants. Key words: necrotising enterocolitis, enteral pause, enteral nutrition, neonatology, birth weight, gestational age, premature infants

Necrotizing enterocolitis: clinical characteristics and outcome of a cohort of 106 cases at a children’s hospital in North China

2020 ◽  
Vol 7 (2) ◽  
pp. 77-84
Author(s):  
Li Hui Rong ◽  
Si Xi Yao ◽  
Jay Narayan Shah ◽  
Jiao Fu Yong
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Gestational Hypertension ◽  
Placenta Previa ◽  
Abdominal Distension ◽  
Altered Mental Status ◽  
Formula Feeding ◽  
Clinical Profile ◽  
Severe Stage

Introduction: Necrotizing enterocolitis (NEC) in neonates, especially in the preterm, is a life-threatening condition. This study aims to analyze the clinical profile of NEC to get an insight for better understanding and management. Method: This was a retrospective analysis of neonatal NEC during the six-year period from 2014 to 2019. The prevalence and time for the development of NEC, clinical profile (term and preterm, low birth weight, gender, breast and formula feeding, abdominal distension, vomiting, hematochezia, apnea, fever, altered mental status, blood transfusion, breast or formula-fed, intestinal perforation, Bell’s stage and time for the development of NEC) and maternal factors (gestational hypertension, diabetes, premature rupture of membranes PROM, intrauterine fetal distress, placenta previa) were analyzed. Features in preterm and term neonates were compared. Ethical approval was obtained. Result: There were 106 NEC (0.87% of 12,184 neonatal admissions), 62 (58.49%) male, 90 (84.91%) preterm, and 85 (80.19%) LBW. Overall, 88 (83.02%) were Bell’s stage II, and severe stage III was seen in eight (19.04%) out of 42 babies with formula feeding as compared to one (1.56%) out of 64 in breastfeeding. The median time for the development of NEC was 6 days of life. The yearly prevalence of NEC per thousand neonates admitted during 6-years increased from 2.90 in 2014 to 12.06 in 2019. Overall mortality was 14 (13.20%). Conclusion: The yearly incidence of NEC increased with a higher incidence in preterm, in low birth weight and formula-fed neonates.

To Determine the Frequency of Necrotizing Enterocolitis in Preterm Infants

2021 ◽  
Vol 15 (12) ◽  
pp. 3200-3201
Author(s):  
Nusrat Hussain ◽  
Suleman . ◽  
Amna Wajdan ◽  
Rabia Bashir ◽  
Rabia Saleem ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
High Frequency ◽  
Cross Sectional Study ◽  
Formula Feeding ◽  
Preterm Neonates ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medicine Department

Aim: To determine the frequency of necrotizing enterocolitis in preterm infants Place and duration of study: It is a descriptive cross-sectional study in Pediatric Medicine Department, Nishtar Hospital Multan from March, 2021 to August, 2021 Methodology: The preterm neonates were called for follow up every week for 4 weeks to diagnose Necrotizing enterocolitis. Results; Out of 174 cases, 101 (58%) were males while 73 (42%) were females. Necrotizing enterocolitis (NEC) was noted in 61 (35.1%) while NEC in breastfeeding infants was 14/74 (18.9%) and in formula feeding infants NEC was 47/100 (47%). Conclusion; High frequency of necrotizing enterocolitis was observed in this study among formula fed preterm infants as compared to breastfed preterm infants. Keywords; Breastfeeding, formula feeding, Necrotizing enterocolitis

Temporal Proteomic Analysis of Intestine Developing Necrotizing Enterocolitis following Enteral Formula Feeding to Preterm Pigs

2009 ◽  
Vol 8 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Pingping Jiang ◽  
Per T. Sangild ◽  
Wai-Hung Sit ◽  
Heidi Hoi-Yee Ngai ◽  
Ruojun Xu ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Proteomic Analysis ◽  
Formula Feeding ◽  
Enteral Formula

61. Formula Feeding Is Associated With Low Levels of Intestinal P-Glycoprotein in the Rat Model of Necrotizing Enterocolitis (NEC)

2008 ◽  
Vol 144 (2) ◽  
pp. 202-203
Author(s):  
Yigit S. Guner ◽  
Nikunj Chokshi ◽  
Diana H. Yu ◽  
Brian Lugo ◽  
Faisal Qureshi ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Rat Model ◽  
Formula Feeding ◽  
P Glycoprotein ◽  
Low Levels

scholarly journals The Small Intestine Proteome Is Changed in Preterm Pigs Developing Necrotizing Enterocolitis in Response to Formula Feeding

2008 ◽  
Vol 138 (10) ◽  
pp. 1895-1901 ◽  
Author(s):  
Pingping Jiang ◽  
Jayda Lee Ann Siggers ◽  
Heidi Hoi-Yee Ngai ◽  
Wai-Hung Sit ◽  
Per T. Sangild ◽  
...  
Keyword(s):  
Small Intestine ◽  
Necrotizing Enterocolitis ◽  
Formula Feeding

Necrotizing enterocolitis, formula feeding, and colostrum

JAMA ◽  
1979 ◽  
Vol 242 (8) ◽  
pp. 713-713
Author(s):  
H. C. Borresen
Keyword(s):  
Necrotizing Enterocolitis ◽  
Formula Feeding

S1709 Enteral Formula Feeding Causes Acute Intestinal Dysfunction and Inflammation in Preterm Pigs During Development of Necrotizing Enterocolitis

2008 ◽  
Vol 134 (4) ◽  
pp. A-254 ◽  
Author(s):  
Jayda L. Siggers ◽  
Richard H. Siggers ◽  
Kerstin Skovgaard ◽  
Thomas Thymann ◽  
Mette Boye ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Formula Feeding ◽  
Enteral Formula
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