scholarly journals A zebrafish larval model reveals early tissue-specific innate immune responses to Mucor circinelloides

2015 ◽  
Vol 8 (11) ◽  
pp. 1375-1388 ◽  
Author(s):  
K. Voelz ◽  
R. L. Gratacap ◽  
R. T. Wheeler
Keyword(s):  
Immune Responses ◽  
Mucor Circinelloides ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Tissue Specific

scholarly journals Tissue-Specific Patterning of Host Innate Immune Responses by Staphylococcus aureus α-Toxin

2014 ◽  
Vol 6 (5) ◽  
pp. 619-631 ◽  
Author(s):  
Russell E.N. Becker ◽  
Bryan J. Berube ◽  
Georgia R. Sampedro ◽  
Andrea C. DeDent ◽  
Juliane Bubeck Wardenburg
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Tissue Specific

Tissue-specific Regulation of Innate Immune Responses by Human Cathelicidin LL-37

2018 ◽  
Vol 24 (10) ◽  
pp. 1079-1091 ◽  
Author(s):  
Panjit Chieosilapatham ◽  
Shigaku Ikeda ◽  
Hideoki Ogawa ◽  
Francois Niyonsaba
Keyword(s):  
Epithelial Cells ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Anatomical Distribution ◽  
Tissue Specific ◽  
Proliferation And Differentiation ◽  
Host Origin ◽  
Specific Factors ◽  
Specific Regulation

Cathelicidins form one of the major families of antimicrobial peptides and have been identified in many vertebrates, including humans. LL-37, the only human member of the cathelicidin family, is detected in most sites of the human body that is normally exposed to microbes, including the epithelial lining of the skin, gastrointestinal tract, genitourinary tract and lungs. This peptide is also expressed by a variety of epithelial cells and immune cells, such as neutrophils, monocytes and mast cells. LL-37 has emerged as a key component of innate immunity due to its direct antimicrobial activity against a broad spectrum of invading pathogens. It also exhibits diverse immunomodulatory functions by activating both pro- and anti-inflammatory mediators; inducing cell migration, proliferation and differentiation; and regulating apoptosis of epithelial cells and neutrophils. Given that the phenotypic and functional properties of immune compartments are different and significantly impacted by the anatomical sites, tissue-specific factors of host origin and microbial communities play important roles in the regulation of LL-37. This review summarizes the expression and biological functions of LL-37 and discusses its significant roles in the innate immune system based on its anatomical distribution.

scholarly journals Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Yinghong Xiao ◽  
Patrick Timothy Dolan ◽  
Elizabeth Faul Goldstein ◽  
Min Li ◽  
Mikhail Farkov ◽  
...  
Keyword(s):  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Tissue Specific

Tissue-specific features of microglial innate immune responses

2021 ◽  
Vol 142 ◽  
pp. 104924
Author(s):  
R. Timmerman ◽  
S.M. Burm ◽  
J.J. Bajramovic
Keyword(s):  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Tissue Specific

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

Innate immune responses and type 1 diabetes: A role for a long non-coding RNA?

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
MP Ashton ◽  
I Tan ◽  
L Mackin ◽  
C Elso ◽  
E Chu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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