scholarly journals Modelling of a targeted nanotherapeutic 'stroma' to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt- -catenin signalling, for use in human fetal dopaminergic grafts in Parkinson's disease

2014 ◽  
Vol 7 (10) ◽  
pp. 1193-1203 ◽  
Author(s):  
J.-W. Zhao ◽  
S. C. Dyson ◽  
C. Kriegel ◽  
P. Tyers ◽  
X. He ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Potent Inhibitor ◽  
Dopaminergic Grafts ◽  
Cytokine Lif

scholarly journals A Sequential Intrastriatal Dopaminergic Graft Strategy in the Rodent Model for Parkinson's Disease: Implications for Graft Survival and Targeting

2002 ◽  
Vol 11 (3) ◽  
pp. 185-193 ◽  
Author(s):  
K. A. Baker ◽  
M. B. Purdy ◽  
D. Sadi ◽  
K. Mukhida ◽  
I. Mendez
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optimal Placement ◽  
Nigrostriatal Pathway ◽  
Total N ◽  
Dopaminergic Grafts ◽  
6 Hydroxydopamine ◽  
The Right ◽  
Final Group ◽  
Important Clinical Implication

Optimal placement of intrastriatal dopaminergic grafts is likely crucial to optimize clinical recovery in Parkinson's disease (PD). The target sites of dopaminergic grafts vary among clinical trials and may partially explain the variable results in clinical efficacy reported thus far. In this study we hypothesized that a subsequent dopaminergic graft may promote functional recovery following a suboptimal initial graft. To test this hypothesis, rats with unilateral 6-hydroxydopamine lesions of the right nigrostriatal pathway were randomly divided into three groups. The first group received 900,000 fetal nigral cells in the medial striatum only (n = 6). The second group received 900,000 cells in both the medial and lateral striatum simultaneously (1.8 million total; n = 8). The final group received a second graft of 900,000 cells in the lateral striatum 6 weeks following initial transplantation of a medial graft (n = 6). Amphetamine-induced circling behavior was significantly reduced in both simultaneous and sequential graft groups at 9 and 12 weeks following transplantation of the initial graft. However, no recovery was noted in the single medial graft group at those time points. Furthermore, increased survival of dopaminergic cells was observed in the lateral graft of sequentially grafted animals compared with the medial graft. We conclude that a well-positioned subsequent graft can restore function in animals with a suboptimal initial graft and that the initial graft may improve survival of the second graft. These results are further discussed in relation to their important clinical implication for neural transplantation in PD.

Restorative potential of dopaminergic grafts in presence of antioxidants in rat model of Parkinson's disease

2004 ◽  
Vol 28 (4) ◽  
pp. 253-264 ◽  
Author(s):  
A.K. Agrawal ◽  
R.K. Chaturvedi ◽  
S. Shukla ◽  
K. Seth ◽  
S. Chauhan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Dopaminergic Grafts

Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease

1997 ◽  
Vol 42 (1) ◽  
pp. 95-107 ◽  
Author(s):  
Gregor K. Wenning ◽  
Per Odin ◽  
Paul Morrish ◽  
Stig Rehncrona ◽  
Håkan Widner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Term Survival ◽  
Long Term Survival ◽  
Short And Long Term ◽  
Dopaminergic Grafts ◽  
And Function

Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts

2000 ◽  
Vol 48 (5) ◽  
pp. 689-695 ◽  
Author(s):  
Paola Piccini ◽  
Olle Lindvall ◽  
Anders Bj�rklund ◽  
Patrik Brundin ◽  
Peter Hagell ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cortical Function ◽  
Delayed Recovery ◽  
Dopaminergic Grafts

Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease

1994 ◽  
Vol 35 (2) ◽  
pp. 172-180 ◽  
Author(s):  
Olle Lindvall ◽  
Guy Sawle ◽  
Håkan Widner ◽  
John C. Rothwell ◽  
Anders Björklund ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Term Survival ◽  
Long Term Survival ◽  
Dopaminergic Grafts ◽  
And Function

The effect of subthalamic nucleus inhibition in the survival of dopaminergic grafts in a rat model of Parkinson's disease

Basal Ganglia ◽  
2013 ◽  
Vol 3 (1) ◽  
pp. 46
Author(s):  
L. Furlanetti ◽  
K. Cordeiro ◽  
J. Cordeiro ◽  
J. Garcia ◽  
C. Winkler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Rat Model ◽  
Dopaminergic Grafts

Temporo-spatial expression of bFGF and TGFβ2 in embryonic dopaminergic grafts in a rat model of Parkinson's disease

1999 ◽  
Vol 69 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Clemens Sommer ◽  
Michael Sabel ◽  
Wolfgang H Oertel ◽  
Marika Kiessling ◽  
Jürgen Sautter
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Spatial Expression ◽  
Dopaminergic Grafts
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