scholarly journals Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia

2013 ◽  
Vol 6 (3) ◽  
pp. 734-744 ◽  
Author(s):  
M. Subramanian ◽  
S. K. Metya ◽  
S. Sadaf ◽  
S. Kumar ◽  
D. Schwudke ◽  
...  
Keyword(s):  
Lipid Homeostasis ◽  
Altered Lipid ◽  
Insp3 Receptor

scholarly journals Altered Lipid Homeostasis in Sertoli Cells Stressed by Mild Hyperthermia

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e91127 ◽  
Author(s):  
Ana S. Vallés ◽  
Marta I. Aveldaño ◽  
Natalia E. Furland
Keyword(s):  
Sertoli Cells ◽  
Lipid Homeostasis ◽  
Mild Hyperthermia ◽  
Altered Lipid

scholarly journals Increased lipolysis and altered lipid homeostasis protect  -synuclein-null mutant mice from diet-induced obesity

2012 ◽  
Vol 109 (51) ◽  
pp. 20943-20948 ◽  
Author(s):  
S. Millership ◽  
N. Ninkina ◽  
I. A. Guschina ◽  
J. Norton ◽  
R. Brambilla ◽  
...  
Keyword(s):  
Mutant Mice ◽  
Lipid Homeostasis ◽  
Null Mutant ◽  
Diet Induced Obesity ◽  
Null Mutant Mice ◽  
Altered Lipid

scholarly journals Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A.

2019 ◽  
Vol 210 ◽  
pp. 30-43 ◽  
Author(s):  
Kathryn A. Crawford ◽  
Bryan W. Clark ◽  
Wendy J. Heiger-Bernays ◽  
Sibel I. Karchner ◽  
Birgit G. Claus Henn ◽  
...  
Keyword(s):  
Fundulus Heteroclitus ◽  
Lipid Homeostasis ◽  
New Bedford Harbor ◽  
Altered Lipid ◽  
Atlantic Killifish

scholarly journals Autophagy is required for lipid homeostasis during dark-induced senescence in Arabidopsis

2020 ◽  
Author(s):  
Jessica AS Barros ◽  
Sahar Magen ◽  
Taly Lapidot-Cohen ◽  
Leah Rosental ◽  
Yariv Brotman ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Lipid Metabolism ◽  
Lipid Droplets ◽  
Metabolic Reprogramming ◽  
Eukaryotic Cells ◽  
Lipid Homeostasis ◽  
Evolutionarily Conserved ◽  
Altered Lipid ◽  
Starvation Conditions

Autophagy is an evolutionarily conserved mechanism that mediates the degradation of cytoplasmic components in eukaryotic cells. In plants, autophagy has been extensively associated with the recycling of proteins during carbon starvation conditions. Even tough lipids constitute a significant energy reserve, our understanding of the function of autophagy in the management of cell lipid reserves and components remains fragmented. To further investigate the significance of autophagy in lipid metabolism, we performed an extensive lipidomic characterization of Arabidopsis (Arabidopsis thaliana) autophagy mutants (atg) submitted to dark-induced senescence conditions. Our results revealed an altered lipid profile in atg mutants, suggesting that autophagy affects the homeostasis of multiple lipid components under dark-induced senescence. The acute degradation of chloroplast lipids coupled with the differential accumulation of triacylglycerols (TAGs) and plastoglobuli-related transcripts indicates an alternative metabolic reprogramming towards lipid storage in atg mutants. The imbalance of lipid metabolism compromises the production of cytosolic lipid droplets and the regulation of peroxisomal lipid oxidation pathways in atg mutants.

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