scholarly journals The zebrafish embryo as a model for assessing off-target drug effects

2010 ◽  
Vol 3 (11-12) ◽  
pp. 689-692 ◽  
Author(s):  
U. Strahle ◽  
C. Grabher
Keyword(s):  
Zebrafish Embryo ◽  
Drug Effects ◽  
Target Drug

Abstract 4907: Elucidating the role of retroactive signaling and kinase inhibitors on off-target drug effects

2011 ◽  
Author(s):  
Michelle L. Wynn ◽  
Alejandra C. Ventura ◽  
Hector Garcia ◽  
Jacques-A. Sepulchre ◽  
Sofia D. Merajver
Keyword(s):  
Kinase Inhibitors ◽  
Drug Effects ◽  
Target Drug

scholarly journals PREDICTION OF OFF-TARGET DRUG EFFECTS THROUGH DATA FUSION

2013 ◽  
Author(s):  
EMMANUEL R. YERA ◽  
ANN E. CLEVES ◽  
AJAY N. JAIN
Keyword(s):  
Data Fusion ◽  
Drug Effects ◽  
Target Drug

scholarly journals Dose-Response Metabolomics To Understand Biochemical Mechanisms and Off-Target Drug Effects with the TOXcms Software

2019 ◽  
Vol 92 (2) ◽  
pp. 1856-1864 ◽  
Author(s):  
Cong-Hui Yao ◽  
Lingjue Wang ◽  
Ethan Stancliffe ◽  
Miriam Sindelar ◽  
Kevin Cho ◽  
...  
Keyword(s):  
Dose Response ◽  
Drug Effects ◽  
Target Drug ◽  
Biochemical Mechanisms

scholarly journals Investigating the Cardiac Effects of Sildenafil loaded Nanoparticles on Heart Failure using the Zebrafish Embryo Model

2020 ◽  
Author(s):  
Heba Adel Mohamed Lotfy Moussa ◽  
Gawaher Saleh Abbas Mahgoub ◽  
Mashael Ali H I Al-Badr ◽  
Huseyin Cagatay Yalcin
Keyword(s):  
Heart Failure ◽  
Zebrafish Embryo ◽  
Drug Effects ◽  
Toxicity Assessment ◽  
Negative Control ◽  
Hatching Rate ◽  
Systematic Effect ◽  
Conventional Drug ◽  
Cardiovascular Therapy ◽  
Heart Injury

Background: Cardiovascular diseases (CVDs) are the first cause of death worldwide. Vasolidator agents are used to relax cardiac muscle, but their extremely short half-lifes limit their effectiveness. Sildenafil is such an agent used to relax the blood vessels muscles and increase the blood flow. The conventional drug can lead to serious problems in patients duo to the systematic drug delivery. Use of Nanomedicine potentially can enhance delivery of this agent while reducing the systematic effect of the drug. Aim: The purpose of the research is to examine the effectiveness sildenafil loaded nanoparticles in rescuing heart failure using zebrafish embryo model. Methods: There will be five experimental groups. The zebrafish will be treated with Aristolochic Acid (AA) at 24 hour per fertilization (hpf) to create the heart injury group. The treatment groups will be heart injury followed by a dose of either Sildenafil or Sildenafil loaded nanoparticles at 36 hpf. Two control groups will be the negative control (exposed to egg water) and vehicle control (exposed to the Dimethylsulfoxide (DMSO)).To evaluate the drug effects on embryo, toxicity assessment (Survival rate, tail flicking and hatching rate), cardiotoxicity assessment and gene expression of heart injury marker via RT-PCR will be conducted. Results: Preliminary findings demonstrate, loading Sildenafil to nanoparticles enhances its effectiveness dramatically. The experiments are ongoing to confirm the results. Conclusion: Nanomedicine is a powerful approach to enhance cardiovascular therapy. Vasodilator drugs in particular will benefit from this improvement as demonstrated with our findings

Off-Target drug effects resulting in altered gene expression events with epigenetic and ⿿Quasi-Epigenetic⿿ origins

2016 ◽  
Vol 107 ◽  
pp. 229-233 ◽  
Author(s):  
Stephen J. Anderson ◽  
Kristina M. Feye ◽  
Garrett R. Schmidt-McCormack ◽  
Emir Malovic ◽  
Gregory S.A. Mlynarczyk ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drug Effects ◽  
Altered Gene Expression ◽  
Target Drug ◽  
Altered Gene

Abstract 2012: Off-target drug effects due to retroactivity in signaling pathways

2010 ◽  
Author(s):  
Michelle Wynn ◽  
Alejandra Ventura ◽  
Hector Garcia ◽  
Sofia Merajver
Keyword(s):  
Signaling Pathways ◽  
Drug Effects ◽  
Target Drug
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