An Immunological Approach to the Problem of Lens Regeneration

Development ◽  
1959 ◽  
Vol 7 (4) ◽  
pp. 549-555
Author(s):  
J. Langman ◽  
B. D. Prescott
Keyword(s):  
Posterior Wall ◽  
Dorsal Part ◽  
Pigment Layer ◽  
Lens Regeneration ◽  
Immunological Approach

Lens regeneration from the dorsal rim of the iris has been observed after removal of the original lens in many species of the genus Triturus (Stone, 1952, 1954, 1958; Zalokar, 1944; Reyer, 1954). Transformation of the iris cells into lens starts with depigmentation and is followed by multiplication of the cells, which become arranged into a vesicle. Subsequently the cells in the posterior wall of the vesicle differentiate into lens fibres and, finally, a new lens is formed. Similarly in the chick (Van Deth, 1939, 1940) removal of the lens primordium from a 53-hour embryo and explantation of the eye-cup resulted in formation of a small lens from both iris epithelium and pigment layer of the retina. However, in the chick the lens-forming potency of the iris was not limited to the dorsal part, but extended also to the ventral rim.

An immuno-fluorescent study of lens regeneration in larval Xenopus laevis

Development ◽  
1965 ◽  
Vol 13 (2) ◽  
pp. 171-179
Author(s):  
John C. Campbell
Keyword(s):  
Xenopus Laevis ◽  
Cell Layer ◽  
Morphological Changes ◽  
Posterior Wall ◽  
Corneal Tissue ◽  
Lens Regeneration ◽  
Small Clump

It is well known that several species of amphibia, especially those of the genus Triturus, can regenerate a lens after removal of the original lens from the eye. In most of these species the regenerate develops from the iris (Reyer, 1954), but in larval Xenopus laevis (Overton &Freeman, 1960; Freeman & Overton, 1961, 1962; Freeman, 1963; Campbell, 1963) and possibly in early embryonic stages of Hynobius unnangso (Ikeda, 1936, 1939) the regenerating lens can be formed from corneal tissue. The morphological changes associated with regeneration of the lens from the cornea in X. laevis have been fully described by Freeman (1963), who has shown that the regenerate develops from the inner cell layer of the outer, or ectodermal, cornea, appearing initially as a small clump of cells in the midpupillary region. This aggregate organizes into a vesicle, from the posterior wall of which the primary lens fibres are formed.

Experimental Amyloidosis Induced by Immune Complex

1971 ◽  
Vol 29 ◽  
pp. 582-583
Author(s):  
A. Kawaoi
Keyword(s):  
Immune Complex ◽  
Systemic Amyloidosis ◽  
Human Diseases ◽  
Experimental Amyloidosis ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Immunological Approach ◽  
Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

Primary Peritoneal Serous Psammocarcinoma: a Case Report

2015 ◽  
Vol 24 (2) ◽  
pp. 253-256 ◽  
Author(s):  
Răzvan Dan Togănel ◽  
Ioan Şimon ◽  
Adriana Zolog ◽  
Răzvan Simescu ◽  
Angela Cozma ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Posterior Wall ◽  
Ca 125 ◽  
Low Grade ◽  
Abdominal Girth ◽  
Treatment Protocols ◽  
Standardized Treatment ◽  
Pelvic Peritonectomy ◽  
Optimal Debulking ◽  
Douglas Pouch

Background: Psammocarcinomas (PCas) are rare epithelial tumors, usually originating in the ovaries or the peritoneum. These tumors are morphologically characterized by extensive psammomatous calcifications, invasiveness and low-grade cytological features.Case report: We present the case of a 54-year-old woman who was referred to our department with an umbilical tumor and increasing abdominal girth. The patient had had an umbilical hernia for more than 20 years. The CA 125 level was normal. The CT scan showed small peritoneal nodules at the level of the Douglas pouch, including the posterior wall of the uterus, and the entire colon, as well as large nodules located on the caecum and the sigmoid colon. We performed partial enterectomy, total colectomy with ileo-rectal anastomosis, omentectomy, total histerectomy and bilateral adnexectomy, pelvic peritonectomy of the Douglas pouch. Pathology findings were consistent with F.I.G.O. stage IIIC peritoneal PCa. The patient received adjuvant chemotherapy with Taxol and Carboplatin. To date, twelve months after surgery, the follow-up shows no evidence of disease.Conclusion: Standardized treatment protocols are hindered by the rarity of the PCas. However, literature concludes that optimal debulking is mandatory, whereas the efficacy of adjuvant chemotherapy remains to be elucidated.

Effekt of blood flow shutdown on the vein damage when exposed to HIFU

2017 ◽  
pp. 46-50
Author(s):  
Н.Н. Петрищев ◽  
Д.Ю. Семенов ◽  
А.Ю. Цибин ◽  
Г.Ю. Юкина ◽  
А.Е. Беркович ◽  
...  
Keyword(s):  
Blood Flow ◽  
Structural Changes ◽  
Focused Ultrasound ◽  
Vena Cava ◽  
Posterior Wall ◽  
High Intensity Focused Ultrasound ◽  
Vein Wall ◽  
Ultrasound Exposure ◽  
Isolated Segment ◽  
The Impact

The purpose. In the study we investigated the impact of the partial blood flow shutdown on structural changes in the rabbit vena cava posterior wall after exposure to high-intensity focused ultrasound (HIFU). Methods. Ultrasound Exposure: frequency of 1.65 MHz, the ultrasound intensity in the focus of 13.6 kW/cm, the area of the focal spot 1 mm, continuous ultrasound, exposure for 3 seconds. Results. Immediately after HIFU exposure all layers of the vein wall showed characteristic signs of thermal damage. A week after exposure structural changes in the intima, media and adventitia was minimal in the part of vessel with preserved blood flow, and after 4 weeks the changes were not revealed. A week after HIFU exposure partial endothelium destruction, destruction of myocytes, disorganization and consolidation of collagen fibers of the adventitia were observed in an isolated segment of the vessel, and in 4 weeks endothelium restored and signs of damage in media and adventitia persisted, but were less obvious than in a week after exposure. Conclusion. The shutdown of blood flow after exposure to HIFU promotes persistent changes in the vein wall. Vein compression appears to be necessary for the obliteration of the vessel, when using HIFU-technology.

COMBINED CORRECTION OF THE CONDITION OF PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY

2020 ◽  
pp. 31-35
Author(s):  
Golovanov S.A. ◽  
Kuznetsov I.A. ◽  
Rasulov M.M.
Keyword(s):  
Posterior Wall ◽  
Biologically Active ◽  
Basic Therapy ◽  
Active Supplement ◽  
Functional Features ◽  
Dimensional Echocardiography ◽  
Stage 1 ◽  
Two Dimensional Echocardiography ◽  
Lipid Spectrum ◽  
Diastolic Functions

Patients from 30 to 50 years old, suffering from arterial hypertonia of stage 1-2 and obesity of 1-2 degree, were exam-ined. Pharmacological correction of cardiovascular disorders and changes in lipid metabolism with the use of dietary supplements "Triastin" against the background of basic therapy of patients with AH and OB with enalapril was car-ried out. In addition to the basic therapy, biologically active supplement Triastin was used in the amount of 2 cap-sules per day for 21 days in 2 cycles for 6 months as an additional hypolipidemic agent. Anthropometric research was carried out using unified methods. Obesity was assessed, as well as the lipid spectrum of the blood. The systolic and diastolic functions of the left ventricle, the size of the aorta, atria and right ventricle, the thickness of the interventric-ular septum in diastole (TMZhPd), the thickness of the posterior wall in diastole (TZSD) were determined using two-dimensional echocardiography. The study revealed a more pronounced and stable decrease in the level of blood pres-sure, lipid profile and side effects of basic therapy, improved myocardial remodeling and its functional features.

Combination of Huangqi Granule and Rosuvastatin Improves the Cardiac Function in Heart Failure

2020 ◽  
Vol 19 (2) ◽  
pp. 181-187
Author(s):  
Jing Li ◽  
Yun Zhang ◽  
Weizhong Huangfu ◽  
Yuhong Ma
Keyword(s):  
Heart Failure ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Wall Thickness ◽  
Posterior Wall ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Model Group ◽  
Ventricular Ejection Fraction ◽  
Posterior Wall Thickness

Using rat models of heart failure, we evaluated the effects of rosuvastatin and Huangqi granule alone and in combination on left ventricular end-diastolic dimension, left ventricular end-systolic dimension, left ventricular ejection fraction, left ventricular posterior wall thickness at end-diastole, and left ventricular posterior wall thickness at end-systole. Results showed that left ventricular end-diastolic dimension, left ventricular end-systolic dimension in the rosuvastatin + Huangqi granule group were significantly decreased (P ‹ 0.01), while left ventricular ejection fraction, left ventricular posterior wall thickness at end-diastole and left ventricular posterior wall thickness at end-systole were significantly increased (P ‹ 0.05). The serum IL-2, IFN-β, and TNF-α in rosuvastatin + Huangqi granule group were significantly lower than those in model group (P ‹ 0.05). However, the levels of S-methylglutathione and superoxide dismutase in rosuvastatin + Huangqi granule group were significantly higher, while nitric oxide was significantly lower than that in the model group (P ‹ 0.05). Also, compared to the model group, the apoptosis rate, and the autophagy protein LC3-II in the cardiomyocytes of rosuvastatin + Huangqi granule group was significantly decreased (P ‹ 0.01), while the level of p62 protein was significantly increased (P ‹ 0.01). The levels of AMPK and p-AMPK in cardiomyocytes were significantly lower in rosuvastatin + Huangqi granule group; however, the levels of mTOR and p-mTOR showed an opposite trend (P ‹ 0.05). To sum up, rosuvastatin + Huangqi granule could improve the cardiac function, decrease the level of oxidative stress, and inflammatory cytokines in rats with HF. The possible underlying mechanism might be inhibition of autophagy and reduced apoptosis in cardiomyocytes by regulating AMPK-mTOR signaling pathway.

Immunological Approach to the Identification and Development of Vaccines to Various Toxins

1990 ◽  
Author(s):  
Tran C. Chanh ◽  
Deborah Armstrong ◽  
Ronald C. Kennedy
Keyword(s):  
Immunological Approach
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