Lethality of radioisotopes in early mouse embryos

Hilary A. Macqueen

doi:10.1242/dev.52.1.203

Lethality of radioisotopes in early mouse embryos

Development ◽

10.1242/dev.52.1.203 ◽

1979 ◽

Vol 52 (1) ◽

pp. 203-208

Author(s):

Hilary A. Macqueen

Keyword(s):

Mouse Embryos ◽

Highly Sensitive ◽

Path Lengths ◽

Early Mouse

The development of pre-implantation mouse embryos was found to be prevented by exposure of the embryos to [35S]methionine, but not to [3H]methionine. Such embryos have also been shown to be highly sensitive to [3H]thymidine. These observations are discussed with reference to the path lengths and energies of electrons emitted from the different radioisotopes.

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Faculty Opinions recommendation of mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1020418.232572 ◽

2004 ◽

Author(s):

Michael Hall

Keyword(s):

Stem Cells ◽

Embryonic Stem Cells ◽

Embryonic Stem ◽

Mouse Embryos ◽

Early Mouse

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Faculty Opinions recommendation of External mechanical cues trigger the establishment of the anterior-posterior axis in early mouse embryos.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718163324.793489568 ◽

2014 ◽

Author(s):

Herbert Steinbeisser

Keyword(s):

Mouse Embryos ◽

Early Mouse ◽

Anterior Posterior ◽

Anterior Posterior Axis

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Expression of fibroblast growth factor receptors by embryonal carcinoma cells and early mouse embryos

In Vitro Cellular & Developmental Biology ◽

10.1007/bf02631080 ◽

1992 ◽

Vol 28 (1) ◽

pp. 61-66 ◽

Cited By ~ 10

Author(s):

Wendy J. Campbell ◽

Keith A. Miller ◽

Todd M. Anderson ◽

James D. Shull ◽

Angie Rizzino

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Embryonal Carcinoma ◽

Growth Factor Receptors ◽

Mouse Embryos ◽

Carcinoma Cells ◽

Fibroblast Growth ◽

Embryonal Carcinoma Cells ◽

Fibroblast Growth Factor Receptors ◽

Early Mouse

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TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos

Cell Death and Differentiation ◽

10.1038/sj.cdd.4402228 ◽

2007 ◽

Vol 15 (2) ◽

pp. 420-422 ◽

Cited By ~ 16

Author(s):

M T Fiorenza ◽

S Torcia ◽

S Canterini ◽

A Bevilacqua ◽

M G Narducci ◽

...

Keyword(s):

Nuclear Transfer ◽

Mouse Embryos ◽

Early Mouse

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The Explanation for the Blockade of Glycolysis in Early Mouse Embryos

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.71.4.1056 ◽

1974 ◽

Vol 71 (4) ◽

pp. 1056-1060 ◽

Cited By ~ 81

Author(s):

E. K. Barbehenn ◽

R. G. Wales ◽

O. H. Lowry

Keyword(s):

Mouse Embryos ◽

Early Mouse

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Cell division and cell allocation in early mouse development

Development ◽

10.1242/dev.48.1.37 ◽

1978 ◽

Vol 48 (1) ◽

pp. 37-51

Author(s):

S. J. Kelly ◽

J. G. Mulnard ◽

C. F. Graham

Keyword(s):

Cell Division ◽

Tritiated Thymidine ◽

Mouse Embryos ◽

Mouse Development ◽

Stages Of Development ◽

Cell Stage ◽

Cell Cycles ◽

Short Cell ◽

Early Mouse

Cell division was observed in intact and dissociated mouse embryos between the 2-cell stage and the blastocyst in embryos developing in culture. Division to the 4-cell stage was usually asynchronous. The first cell to divide to the 4-cell stage produced descendants which tended to divide ahead of those cells produced by its slow partner at all subsequent stages of development up to the blastocyte stage. The descendants of the first cell to divide to the 4-cell stage did not subsequently have short cell cycles. The first cell or last cell to divide from the 4-cell stage was labelled with tritiated thymidine. The embryo was reassembled, and it was found that the first pair of cells to reach the 8-cell stage contributed disproportionately more descendants to the ICM when compared with the last cell to divide to the 8-cell stage.

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