scholarly journals Lineage-specific control of convergent differentiation by a Forkhead repressor

Development ◽  
2021 ◽  
Author(s):  
Karolina Mizeracka ◽  
Julia M. Rogers ◽  
Jonathan D. Rumley ◽  
Shai Shaham ◽  
Martha L. Bulyk ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Human Homolog ◽  
Cell Type ◽  
Forkhead Transcription Factor ◽  
C Elegans ◽  
A Cell ◽  
Identical Cell ◽  
Cell Type Specific ◽  
Activate Cell ◽  
Specific Control

During convergent differentiation, multiple developmental lineages produce a highly similar or identical cell type. However, few molecular players that drive convergent differentiation are known. Here, we show that the C. elegans Forkhead transcription factor UNC-130 is required in only one of three convergent lineages that produce the same glial cell type. UNC-130 acts transiently as a repressor in progenitors and newly-born terminal cells to allow the proper specification of cells related by lineage rather than by cell type or function. Specification defects correlate with UNC-130:DNA binding, and UNC-130 can be functionally replaced by its human homolog, the neural crest lineage determinant FoxD3. We propose that, in contrast to terminal selectors that activate cell-type specific transcriptional programs in terminally differentiating cells, UNC-130 acts early and specifically in one convergent lineage to produce a cell type that also arises from molecularly distinct progenitors in other lineages.

scholarly journals Lineage-specific control of convergent differentiation by a Forkhead repressor

2019 ◽  
Author(s):  
Karolina Mizeracka ◽  
Julia M. Rogers ◽  
Jonathan D. Rumley ◽  
Shai Shaham ◽  
Martha L. Bulyk ◽  
...  
Keyword(s):  
Cell Types ◽  
Human Homolog ◽  
Cell Type ◽  
Forkhead Transcription Factor ◽  
C Elegans ◽  
Identical Cell ◽  
Cell Type Specific ◽  
Activate Cell ◽  
Type Specification ◽  
Specific Control

ABSTRACTDuring convergent differentiation, multiple developmental lineages produce a highly similar or identical cell type. However, the molecular players that drive convergent differentiation are not known. Here, we show that the C. elegans Forkhead transcription factor UNC-130 is required in only one of three convergent lineages that produce the same glial cell type. UNC-130 acts transiently as a repressor in progenitors and newly-born terminal cells to allow the proper specification of cells related by lineage rather than by cell type. Specification defects correlate with UNC-130:DNA binding, and UNC-130 can be functionally replaced by its human homolog, the neural crest lineage determinant FoxD3. We propose that, in contrast to terminal selectors that activate cell-type specific transcriptional programs in terminally differentiating cells, UNC-130 acts earlier to enable molecularly distinct progenitors to produce equivalent cell types. These findings provide evidence that convergent differentiation involves distinct transcriptional paths leading to the same cell type.

The Promoter Activity of the Phospholipase C-γ2 Gene Is Regulated by a Cell-Type-Specific Control Element

1997 ◽  
Vol 16 (4) ◽  
pp. 485-492 ◽  
Author(s):  
SEUNG-JAE LEE ◽  
YOUNG YIL BAHK ◽  
DOO HEE YUN ◽  
HE-JIN LEE ◽  
YOUNG HAN LEE ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Promoter Activity ◽  
Control Element ◽  
Cell Type ◽  
A Cell ◽  
Cell Type Specific ◽  
Specific Control ◽  
Γ2 Gene

scholarly journals Regulation of a Cell Type-specific Silencer in the Human Interleukin-3 Gene Promoter by the Transcription Factor YY1 and an AP2 Sequence-recognizing Factor

1999 ◽  
Vol 274 (38) ◽  
pp. 26661-26667 ◽  
Author(s):  
Jianping Ye ◽  
Howard A. Young ◽  
Xiaoying Zhang ◽  
Vince Castranova ◽  
Val Vallyathan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Gene Promoter ◽  
Cell Type ◽  
Interleukin 3 ◽  
A Cell ◽  
Cell Type Specific ◽  
Transcription Factor Yy1

scholarly journals Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain.

1995 ◽  
Vol 15 (5) ◽  
pp. 2849-2857 ◽  
Author(s):  
A P Bradford ◽  
K E Conrad ◽  
C Wasylyk ◽  
B Wasylyk ◽  
A Gutierrez-Hartmann
Keyword(s):  
Transcription Factor ◽  
Molecular Mechanism ◽  
Specific Gene ◽  
Ras Signaling ◽  
Cell Type ◽  
Functional Interaction ◽  
Amino Terminal ◽  
Ras Activation ◽  
A Cell ◽  
Cell Type Specific

The mechanism by which activation of common signal transduction pathways can elicit cell-specific responses remains an important question in biology. To elucidate the molecular mechanism by which the Ras signaling pathway activates a cell-type-specific gene, we have used the pituitary-specific rat prolactin (rPRL) promoter as a target of oncogenic Ras and Raf in GH4 rat pituitary cells. Here we show that expression of either c-Ets-1 or the POU homeo-domain transcription factor GHF-1/Pit-1 enhance the Ras/Raf activation of the rPRL promoter and that coexpression of the two transcription factors results in an even greater synergistic Ras response. By contrast, the related GHF-1-dependent rat growth hormone promoter fails to respond to Ras or Raf, indicating that GHF-1 alone is insufficient to mediate the Ras/Raf effect. Using amino-terminal truncations of c-Ets-1, we have mapped the c-Ets-1 region required to mediate the optimal Ras response to a 40-amino-acid segment which contains a putative mitogen-activated protein kinase site. Finally, dominant-negative Ets and GHF constructs block Ras activation of the rPRL promoter, and each blocks the synergistic activation mediated by the other partner protein, further corroborating that a functional interaction between c-Ets-1 and GHF-1 is required for an optimal Ras response. Thus, the functional interaction of a pituitary-specific transcription factor, GHF-1, with a widely expressed nuclear proto-oncogene product, c-Ets-1, provides one important molecular mechanism by which the general Ras signaling cascade can be interpreted in a cell-type-specific manner.

IFIH1-deficiency results in a cell-type specific alteration of autophagic activity in response to S. typhimurium

2017 ◽  
Vol 55 (05) ◽  
pp. e28-e56
Author(s):  
S Macheiner ◽  
R Gerner ◽  
A Pfister ◽  
A Moschen ◽  
H Tilg
Keyword(s):  
Cell Type ◽  
A Cell ◽  
Cell Type Specific ◽  
Autophagic Activity ◽  
Specific Alteration
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