scholarly journals Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis

Development ◽  
2020 ◽  
Vol 147 (15) ◽  
pp. dev192070
Author(s):  
Kazuya Ono ◽  
Lisa L. Sandell ◽  
Paul A. Trainor ◽  
Doris K. Wu
Keyword(s):  
Retinoic Acid ◽  
Inner Ear ◽  
Acid Synthesis ◽  
Vestibular Organs

scholarly journals CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development

JCI Insight ◽  
2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Hui Yao ◽  
Sophie F. Hill ◽  
Jennifer M. Skidmore ◽  
Ethan D. Sperry ◽  
Donald L. Swiderski ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Inner Ear ◽  
Acid Synthesis ◽  
Ear Development ◽  
Inner Ear Development

Citral, an inhibitor of retinoic acid synthesis, modifies pattern formation during limb regeneration in the axolotl Ambystoma mexicanum

1999 ◽  
Vol 77 (11) ◽  
pp. 1835-1837 ◽  
Author(s):  
Steven R Scadding
Keyword(s):  
Retinoic Acid ◽  
Pattern Formation ◽  
Limb Regeneration ◽  
Acid Synthesis ◽  
Ambystoma Mexicanum

While the effects of exogenous retinoids on amphibian limb regeneration have been studied extensively, the role of endogenous retinoids is not clear. Hence, I wished to investigate the role of endogenous retinoic acid during axolotl limb regeneration. Citral is a known inhibitor of retinoic acid synthesis. Thus, I treated regenerating limbs of the larval axolotl Ambystoma mexicanum with citral. The result of this inhibition of retinoic acid synthesis was that limb regeneration became extremely irregular and hypomorphic, with serious pattern defects, or was inhibited altogether. I conclude that endogenous retinoic acid plays an important role in pattern formation during limb regeneration.

Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin

2021 ◽  
Author(s):  
Helen B. Everts ◽  
Kathleen A. Silva ◽  
Adriana N. Schmidt ◽  
Susan Opalenikx ◽  
F. Jason Duncan ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Binding Proteins ◽  
Mouse Skin ◽  
Acid Synthesis

scholarly journals Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis

Immunity ◽  
2018 ◽  
Vol 49 (6) ◽  
pp. 1103-1115.e6 ◽  
Author(s):  
Mayara Grizotte-Lake ◽  
Guo Zhong ◽  
Kellyanne Duncan ◽  
Jay Kirkwood ◽  
Namrata Iyer ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cell ◽  
Intestinal Epithelial Cell ◽  
Acid Synthesis ◽  
Intestinal Epithelial ◽  
Interleukin 22 ◽  
Microbial Dysbiosis

Anti-apoptotic role of retinoic acid in the inner ear of noise-exposed mice

2005 ◽  
Vol 335 (2) ◽  
pp. 485-490 ◽  
Author(s):  
Joong Ho Ahn ◽  
Hun Hee Kang ◽  
Young-Jin Kim ◽  
Jong Woo Chung
Keyword(s):  
Retinoic Acid ◽  
Inner Ear

scholarly journals Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice

2003 ◽  
Vol 100 (4) ◽  
pp. 1763-1768 ◽  
Author(s):  
J. Vermot ◽  
K. Niederreither ◽  
J.-M. Garnier ◽  
P. Chambon ◽  
P. Dolle
Keyword(s):  
Retinoic Acid ◽  
Digeorge Syndrome ◽  
Acid Synthesis ◽  
Newborn Mice

Retinoic acid modulation of the early development of the inner ear is associated with the control of c-fos expression

Development ◽  
1990 ◽  
Vol 110 (4) ◽  
pp. 1081-1090 ◽  
Author(s):  
J. Represa ◽  
A. Sanchez ◽  
C. Miner ◽  
J. Lewis ◽  
F. Giraldez
Keyword(s):  
Cell Proliferation ◽  
Retinoic Acid ◽  
Inner Ear ◽  
Early Development ◽  
Otic Vesicle ◽  
Low Concentrations ◽  
Full Effect ◽  
20 Nm ◽  
Otic Vesicles

The effects of retinoic acid (RA) on the early development of the inner ear were studied in vitro using isolated chick embryo vesicles. Low concentrations of RA (1–50 nM) inhibited vesicular growth in stage 18 otic vesicles that were made quiescent and then reactivated by either serum or bombesin. Growth inhibition was concentration-dependent and was paralleled by a reduction in the rate of DNA synthesis as measured by [3H]thymidine incorporation. Half-inhibition occurred between 1 and 10 nM RA, and the full effect at 20 nM. Retinoic acid, in the presence of serum, induced the precocious differentiation of (1) secretory epithelium, the tegmentum vasculosum and endolymphatic sac and (2) early sensory and supporting epithelia. These structures were positioned in their corresponding normal presumptive areas. The overall direction of growth was reversed by RA and the ratio of the internal to the external vesicular surface area increased with RA concentration. The expression of the nuclear proto-oncogene c-fos in the developing otic vesicle was transient and stage-dependent. High levels of c-fos mRNA were positively correlated with cell proliferation. Incubation of growth-arrested otic vesicles with bombesin plus insulin at concentrations that induced cell proliferation produced a strong induction of c-fos. This mitogen-induced expression was suppressed by 25 nM RA. The results suggest (1) a role for retinoic acid in controlling the early development of the inner ear and (2) that this control is effected through the regulation of the proto-oncogene c-fos.

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