scholarly journals Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors

Development ◽  
2019 ◽  
Vol 146 (23) ◽  
pp. dev183400 ◽  
Author(s):  
Merve Deniz Abdusselamoglu ◽  
Lisa Landskron ◽  
Sarah K. Bowman ◽  
Elif Eroglu ◽  
Thomas Burkard ◽  
...  
Keyword(s):  
Stem Cell ◽  
Brain Tumors ◽  
Neural Stem Cell ◽  
Histone Modifications ◽  
Cell Lineages

scholarly journals Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors

2019 ◽  
Author(s):  
Merve Deniz Abdusselamoglu ◽  
Lisa Landskron ◽  
Sarah K. Bowman ◽  
Elif Eroglu ◽  
Thomas Burkard ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Neural Stem Cell ◽  
Histone Modifications ◽  
Cell Types ◽  
Polycomb Group ◽  
Epigenetic Landscape ◽  
Cell Lineages

AbstractDuring central nervous system (CNS) development, spatiotemporal gene expression programs mediate specific lineage decisions to generate neuronal and glial cell types from neural stem cells (NSCs). However, little is known about the epigenetic landscape underlying these highly complex developmental events. Here, we perform ChIP-seq on distinct subtypes of Drosophila FACS-purified neural stem cells (NSCs) and their differentiated progeny to dissect the epigenetic changes accompanying the major lineage decisions in vivo. By analyzing active and repressive histone modifications, we show that stem cell identity genes are silenced during differentiation by loss of their activating marks and not via repressive histone modifications. Our analysis also uncovers a new set of genes specifically required for altering lineage patterns in type II neuroblasts, one of the two main Drosophila NSC identities. Finally, we demonstrate that this subtype specification in NBs, unlike NSC differentiation, requires Polycomb-group (PcG)-mediated repression.Summary statementDynamic epigenetic landscape of Drosophila neural stem cell lineages.

Histone modifications controlling native and induced neural stem cell identity

2015 ◽  
Vol 34 ◽  
pp. 95-101 ◽  
Author(s):  
Vania Broccoli ◽  
Gaia Colasante ◽  
Alessandro Sessa ◽  
Alicia Rubio
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Histone Modifications ◽  
Cell Identity ◽  
Induced Neural Stem Cell

Flow Cytometric Analysis of Neural Stem Cell Markers on Pediatric Brain Tumors

Neurosurgery ◽  
2005 ◽  
Vol 57 (2) ◽  
pp. 434-434
Author(s):  
Samuel Cheshier ◽  
Laurie E. Ailles ◽  
Michael Lim ◽  
Paul Laddis ◽  
Victor C.K. Tse ◽  
...  
Keyword(s):  
Stem Cell ◽  
Brain Tumors ◽  
Neural Stem Cell ◽  
Flow Cytometric Analysis ◽  
Pediatric Brain Tumors ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Flow Cytometric ◽  
Pediatric Brain

scholarly journals Neural stem cell-based dual suicide gene delivery for metastatic brain tumors

2012 ◽  
Vol 19 (11) ◽  
pp. 796-801 ◽  
Author(s):  
C Wang ◽  
A Natsume ◽  
H J Lee ◽  
K Motomura ◽  
Y Nishimira ◽  
...  
Keyword(s):  
Stem Cell ◽  
Gene Delivery ◽  
Brain Tumors ◽  
Neural Stem Cell ◽  
Suicide Gene ◽  
Metastatic Brain Tumors

scholarly journals miR-17~92 exerts stage-specific effects in adult V-SVZ neural stem cell lineages

2021 ◽  
Author(s):  
Fabrizio Favaloro ◽  
Annina DeLeo ◽  
Ana Delgado ◽  
Fiona Doetsch
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Oligodendrocyte Progenitor Cells ◽  
Dependent Manner ◽  
Cell Lineages ◽  
Conditional Deletion ◽  
Specific Effects ◽  
Cell Type Specific

In the adult mouse brain, neural stem cells (NSCs) in the ventricular-subventricular zone (V-SVZ) generate neurons and glia throughout life. microRNAs are important regulators of cell states, frequently acting in a stage- or context-dependent manner. Here, miRNA profiling of FACS-purified populations identified miR-17~92 as highly upregulated in activated NSCs and transit amplifying cells (TACs) in comparison to quiescent NSCs. Conditional deletion of miR-17~92 in NSCs reduced stem cell proliferation both in vitro and in vivo. In contrast, in TACs, miR-17~92 deletion caused a selective shift from neurogenic DLX2+ TACs towards oligodendrogenic OLIG2+ TACs, resulting in increased oligodendrogenesis to the corpus callosum. miR-17~92 deletion also decreased proliferation and maturation of intraventricular oligodendrocyte progenitor cells. Together, these findings reveal stage- and cell-type- specific functions of the miR-17~92 cluster within adult V-SVZ neural stem cell lineages.

scholarly journals Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

Cell Reports ◽  
2019 ◽  
Vol 26 (2) ◽  
pp. 394-406.e5 ◽  
Author(s):  
Dogukan Mizrak ◽  
Hanna Mendes Levitin ◽  
Ana C. Delgado ◽  
Valerie Crotet ◽  
Jinzhou Yuan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Cell ◽  
Neural Stem Cell ◽  
Regional Differences ◽  
Single Cell Analysis ◽  
Cell Analysis ◽  
Cell Lineages

scholarly journals N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

2018 ◽  
Vol 21 (2) ◽  
pp. 195-206 ◽  
Author(s):  
Yang Wang ◽  
Yue Li ◽  
Minghui Yue ◽  
Jun Wang ◽  
Sandeep Kumar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Histone Modifications ◽  
Rna Modification ◽  
Self Renewal ◽  
Embryonic Neural Stem Cell
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