scholarly journals A Notch-regulated proliferative stem cell zone in the developing spinal cord is an ancestral vertebrate trait

Development ◽  
2018 ◽  
Vol 146 (1) ◽  
pp. dev166595 ◽  
Author(s):  
Ricardo Lara-Ramirez ◽  
Carlos Pérez-González ◽  
Chiara Anselmi ◽  
Cedric Patthey ◽  
Sebastian M. Shimeld
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Ancestral Vertebrate ◽  
Developing Spinal Cord ◽  
Cell Zone

Stem Cell Transplantation: A Promising Therapy for Spinal Cord Injury

2020 ◽  
Vol 15 (4) ◽  
pp. 321-331 ◽  
Author(s):  
Zhe Gong ◽  
Kaishun Xia ◽  
Ankai Xu ◽  
Chao Yu ◽  
Chenggui Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Potential ◽  
Embryonic Stem ◽  
Current Status ◽  
Cord Injury

Spinal Cord Injury (SCI) causes irreversible functional loss of the affected population. The incidence of SCI keeps increasing, resulting in huge burden on the society. The pathogenesis of SCI involves neuron death and exotic reaction, which could impede neuron regeneration. In clinic, the limited regenerative capacity of endogenous cells after SCI is a major problem. Recent studies have demonstrated that a variety of stem cells such as induced Pluripotent Stem Cells (iPSCs), Embryonic Stem Cells (ESCs), Mesenchymal Stem Cells (MSCs) and Neural Progenitor Cells (NPCs) /Neural Stem Cells (NSCs) have therapeutic potential for SCI. However, the efficacy and safety of these stem cellbased therapy for SCI remain controversial. In this review, we introduce the pathogenesis of SCI, summarize the current status of the application of these stem cells in SCI repair, and discuss possible mechanisms responsible for functional recovery of SCI after stem cell transplantation. Finally, we highlight several areas for further exploitation of stem cells as a promising regenerative therapy of SCI.

scholarly journals EP Receptor Expression in Human Intestinal Epithelium and Localization Relative to the Stem Cell Zone of the Crypts

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e26816 ◽  
Author(s):  
Lene Th. Olsen Hult ◽  
Charlotte R. Kleiveland ◽  
Kjetil Fosnes ◽  
Morten Jacobsen ◽  
Tor Lea
Keyword(s):  
Stem Cell ◽  
Intestinal Epithelium ◽  
Receptor Expression ◽  
Ep Receptor ◽  
Human Intestinal Epithelium ◽  
Cell Zone

scholarly journals Dorsal commissural axon guidance in the developing spinal cord

2020 ◽  
Author(s):  
Sandy Alvarez ◽  
Supraja G. Varadarajan ◽  
Samantha J. Butler
Keyword(s):  
Spinal Cord ◽  
Axon Guidance ◽  
Commissural Axon ◽  
Developing Spinal Cord

Pentapeptide IKVAV-engineered hydrogels for neural stem cell attachment

2021 ◽  
Author(s):  
Yixia Yin ◽  
Wenwu Wang ◽  
Qi Shao ◽  
Binbin Li ◽  
Dan Yu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Attachment ◽  
Injury Repair ◽  
Cord Injury ◽  
Proliferation Ability

A IKVAV-functionalized hydrogel is developed. It not only enhances neural stem cell (NSC) attachment, growth, and differentiation, but also maintains the proliferation ability of the NSC spheroids in the hydrogel for spinal cord injury repair.

scholarly journals 19-P013 Regeneration of the spinal cord from a single neural stem cell

2009 ◽  
Vol 126 ◽  
pp. S295
Author(s):  
Levan Mchedlishvili ◽  
Shahryar Khattak ◽  
Elly Tanaka
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Neural Stem Cell

scholarly journals Expression and Cellular Distribution of Ubiquitin in Response to Injury in the Developing Spinal Cord of Monodelphis domestica

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62120 ◽  
Author(s):  
Natassya M. Noor ◽  
Kjeld Møllgård ◽  
Benjamin J. Wheaton ◽  
David L. Steer ◽  
Jessie S. Truettner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Monodelphis Domestica ◽  
Cellular Distribution ◽  
Developing Spinal Cord
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