scholarly journals RPSA, a candidate gene for isolated congenital asplenia, is required for pre-rRNA processing and spleen formation in Xenopus

Development ◽  
2018 ◽  
Vol 145 (20) ◽  
pp. dev166181 ◽  
Author(s):  
John N. Griffin ◽  
Samuel B. Sondalle ◽  
Andrew Robson ◽  
Emily K. Mis ◽  
Gerald Griffin ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Rrna Processing ◽  
Isolated Congenital Asplenia

Nuclear coiled bodies and the nucleolus

1994 ◽  
Vol 52 ◽  
pp. 20-21
Author(s):  
K. Brasch ◽  
J. Williams ◽  
D. Gallo ◽  
T. Lee ◽  
R. L. Ochs
Keyword(s):  
Mouse Liver ◽  
Nuclear Body ◽  
Nuclear Bodies ◽  
Model Systems ◽  
Coiled Body ◽  
Rrna Processing ◽  
Malignant Cells ◽  
Sm Proteins ◽  
Coiled Bodies ◽  
Unique Protein

Though first described in 1903 by Ramon-y-Cajal as silver-staining “accessory bodies” to nucleoli, nuclear bodies were subsequently rediscovered by electron microscopy about 30 years ago. Nuclear bodies are ubiquitous, but seem most abundant in hyperactive and malignant cells. The best studied type of nuclear body is the coiled body (CB), so termed due to characteristic morphology and content of a unique protein, p80-coilin (Fig.1). While no specific functions have as yet been assigned to CBs, they contain spliceosome snRNAs and proteins, and also the nucleolar protein fibrillarin. In addition, there is mounting evidence that CBs arise from or are generated near the nucleolus and then migrate into the nucleoplasm. This suggests that as yet undefined links may exist, between nucleolar pre-rRNA processing events and the spliceosome-associated Sm proteins in CBs.We are examining CB and nucleolar changes in three diverse model systems: (1) estrogen stimulated chick liver, (2) normal and neoplastic cells, and (3) polyploid mouse liver.

A candidate gene study in predicted severe acute pancretitis

2001 ◽  
Vol 120 (5) ◽  
pp. A468-A468 ◽  
Author(s):  
G GALLAGHER ◽  
P CHONG ◽  
J ESKDALE ◽  
A COOK ◽  
S CAIMS ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Candidate Gene Study ◽  
Gene Study ◽  
Acute Pancretitis

The cholesterol transporter Abcg1, a candidate gene for obesity: deletion of Abcg1 in mice corrects diet-induced insulin resistance

2007 ◽  
Vol 2 (S 1) ◽  
Author(s):  
J Buchmann ◽  
C Meyer ◽  
S Neschen ◽  
R Kluge ◽  
R Wehr ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Candidate Gene

GIRK2 – A novel candidate gene for attention deficit hyperactivity disorder

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
C Röser ◽  
TJ Renner ◽  
S Walitza ◽  
A Dempfle ◽  
T Nguyen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Candidate Gene ◽  
Attention Deficit ◽  
Hyperactivity Disorder

Glucokinase and NIDDM. A candidate gene that paid off

Diabetes ◽  
1992 ◽  
Vol 41 (11) ◽  
pp. 1367-1372 ◽  
Author(s):  
M. A. Permutt ◽  
K. C. Chiu ◽  
Y. Tanizawa
Keyword(s):  
Candidate Gene

Molecular Analysis of KCNJ10 on 1q as a Candidate Gene for Type 2 Diabetes in Pima Indians

Diabetes ◽  
2002 ◽  
Vol 51 (11) ◽  
pp. 3342-3346 ◽  
Author(s):  
V. S. Farook ◽  
R. L. Hanson ◽  
J. K. Wolford ◽  
C. Bogardus ◽  
M. Prochazka
Keyword(s):  
Type 2 Diabetes ◽  
Candidate Gene ◽  
Molecular Analysis ◽  
Pima Indians

Candidate Gene Discovery for Dog Cryptorchidism

2008 ◽  
Author(s):  
Xia Zhao ◽  
Kim Glenn ◽  
Zhiqiang Du ◽  
Max F. Rothschild
Keyword(s):  
Candidate Gene ◽  
Gene Discovery
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