scholarly journals Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle throughCdk6expression

Development ◽  
2018 ◽  
Vol 145 (17) ◽  
pp. dev163147 ◽  
Author(s):  
Kerstin Hasenpusch-Theil ◽  
Stephen West ◽  
Alexandra Kelman ◽  
Zrinko Kozic ◽  
Sophie Horrocks ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Glial Cell ◽  
Radial Glial Cell ◽  
Cortical Neurogenesis ◽  
Radial Glial

scholarly journals Minor spliceosome inactivation in the developing mouse cortex causes self-amplifying radial glial cell death and microcephaly

2017 ◽  
Author(s):  
Marybeth Baumgartner ◽  
Anouk M. Olthof ◽  
Katery C. Hyatt ◽  
Christopher Lemoine ◽  
Kyle Drake ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Glial Cell ◽  
Progenitor Cell ◽  
Intron Retention ◽  
Cortical Development ◽  
Conditional Knockout ◽  
Small Nuclear Rna ◽  
Radial Glial Cell ◽  
Nuclear Rna ◽  
Radial Glial

AbstractInactivation of the minor spliceosome has been linked to microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1). To interrogate how minor intron splicing regulates cortical development, we employed Emx1-Cre to ablate Rnu11, which encodes the minor spliceosome-specific U11 small nuclear RNA (snRNA), in the developing cortex (pallium). Rnu11 cKO mice were born with microcephaly, caused by death of self-amplifying radial glial cells (RGCs). However, both intermediate progenitor cells (IPCs) and neurons were produced in the U11-null pallium. RNAseq of the pallium revealed elevated minor intron retention in the mutant, particularly in genes regulating cell cycle. Moreover, the only downregulated minor intron-containing gene (MIG) was Spc24, which regulates kinetochore assembly. These findings were consistent with the observation of fewer RGCs entering cytokinesis prior to RGC loss, underscoring the requirement of minor splicing for cell cycle progression in RGCs. Overall, we provide a potential explanation of how disruption of minor splicing might cause microcephaly in MOPD1.Summary StatementHere we report the first mammalian model to investigate the role of the minor spliceosome in cortical development and microcephaly.List of abbreviations usedMOPD1=microcephalic osteodysplastic primordial dwarfism type 1; snRNA=small nuclear RNA; cKO=conditional knockout; NPC=neural progenitor cell; RGC=radial glial cell; IPC=intermediate progenitor cell; MIG=minor intron-containing gene

scholarly journals C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment

Development ◽  
2008 ◽  
Vol 135 (12) ◽  
pp. 2139-2149 ◽  
Author(s):  
A. K. Voss ◽  
J. M. Britto ◽  
M. P. Dixon ◽  
B. N. Sheikh ◽  
C. Collin ◽  
...  
Keyword(s):  
Cortical Neuron ◽  
Glial Cell ◽  
Cell Attachment ◽  
Radial Glial Cell ◽  
Neuron Migration ◽  
Radial Glial

scholarly journals Spatiotemporal transcriptome at single-cell resolution reveals key radial glial cell population in axolotl telencephalon development and regeneration

2021 ◽  
Author(s):  
Xiaoyu Wei ◽  
Sulei Fu ◽  
Hanbo Li ◽  
Yang Liu ◽  
Shuai Wang ◽  
...  
Keyword(s):  
Single Cell ◽  
Glial Cell ◽  
Cell Population ◽  
Cell Types ◽  
Mammalian Brain ◽  
Regeneration Ability ◽  
Radial Glial Cell ◽  
Cell Dynamics ◽  
Brain Regeneration ◽  
Radial Glial

Brain regeneration requires a precise coordination of complex responses in a time- and region-specific manner. Identifying key cell types and molecules that direct brain regeneration would provide potential targets for the advance of regenerative medicine. However, progress in the field has been hampered largely due to very limited regeneration capacity of the mammalian brain and understanding of the regeneration process at both cellular and molecular level. Here, using axolotl brain with astonishing regeneration ability upon injury, and the Stereo-seq (SpaTial Enhanced REsolution Omics-sequencing), we reconstruct the first architecture of axolotl telencephalon with gene expression profiling at single-cell resolution, and fine cell dynamics maps throughout development and regeneration. Intriguingly, we discover a marked heterogeneity of radial glial cell (RGC) types with distinct behaviors. Of note, one subtype of RGCs is activated since early regeneration stages and proliferates while other RGCs remain dormant. Such RGC subtype appears to be the major cell population involved in early wound healing response and gradually covers the injured area before presumably transformed into the lost neurons. Altogether, our work systematically decodes the complex cellular and molecular dynamics of axolotl telencephalon in development and regeneration, laying the foundation for studying the regulatory mechanism of brain regeneration in future.

scholarly journals Memo1 Tiles the Radial Glial Cell Grid

Neuron ◽  
2019 ◽  
Vol 103 (5) ◽  
pp. 750-752
Author(s):  
Ximena Contreras ◽  
Simon Hippenmeyer
Keyword(s):  
Glial Cell ◽  
Radial Glial Cell ◽  
Radial Glial

scholarly journals The role of the EG5 kinesin in regulating radial glial cell number

2007 ◽  
Vol 306 (1) ◽  
pp. 329-330
Author(s):  
Kristina M. DiPietrantonio ◽  
Alissa Ortman ◽  
Rolf Karlstrom ◽  
Adam Amsterdam ◽  
Nancy Hopkins ◽  
...  
Keyword(s):  
Glial Cell ◽  
Cell Number ◽  
Radial Glial Cell ◽  
Radial Glial

scholarly journals Radial Glial Cell-Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site

2015 ◽  
Vol 35 (43) ◽  
pp. 14517-14532 ◽  
Author(s):  
C. Xu ◽  
Y. Funahashi ◽  
T. Watanabe ◽  
T. Takano ◽  
S. Nakamuta ◽  
...  
Keyword(s):  
Glial Cell ◽  
Radial Glial Cell ◽  
Contact Site ◽  
Neuron Interaction ◽  
Radial Glial

Comparative analysis ofTsc1andTsc2single and double radial glial cell mutants

2013 ◽  
Vol 521 (16) ◽  
pp. 3817-3831 ◽  
Author(s):  
Ulrike Mietzsch ◽  
James McKenna ◽  
R. Michelle Reith ◽  
Sharon W. Way ◽  
Michael J. Gambello
Keyword(s):  
Comparative Analysis ◽  
Glial Cell ◽  
Radial Glial Cell ◽  
Radial Glial
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