scholarly journals Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing

Development ◽  
2018 ◽  
Vol 145 (21) ◽  
pp. dev163105 ◽  
Author(s):  
Leah B. Nantie ◽  
Randee E. Young ◽  
Wyatt G. Paltzer ◽  
Yan Zhang ◽  
Randy L. Johnson ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Alveolar Type ◽  
Type I ◽  
Air Breathing ◽  
Alveolar Type I Cell

scholarly journals Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung

2016 ◽  
Vol 414 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Xiaoru Wang ◽  
Yi Wang ◽  
Melinda E. Snitow ◽  
Kathleen M. Stewart ◽  
Shanru Li ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Wnt Signaling ◽  
Histone Deacetylase ◽  
Alveolar Type ◽  
Type I ◽  
Histone Deacetylase 3 ◽  
Alveolar Type I Cell

scholarly journals Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate

2018 ◽  
Vol 115 (10) ◽  
pp. 2407-2412 ◽  
Author(s):  
Yanjie Wang ◽  
Zan Tang ◽  
Huanwei Huang ◽  
Jiao Li ◽  
Zheng Wang ◽  
...  
Keyword(s):  
Cell Fate ◽  
Cell Population ◽  
Developmental Plasticity ◽  
Alveolar Type ◽  
Type I ◽  
Rna Seq ◽  
Cell Fates ◽  
Distinct Cell ◽  
Alveolar Surface ◽  
Alveolar Type I Cell

Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air–blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration. However, the development and heterogeneity of AT1 cells remain largely unknown. Here, we conducted a single-cell RNA-seq analysis to characterize postnatal AT1 cell development and identified insulin-like growth factor-binding protein 2 (Igfbp2) as a genetic marker specifically expressed in postnatal AT1 cells. The portion of AT1 cells expressing Igfbp2 increases during alveologenesis and in post pneumonectomy (PNX) newly formed alveoli. We found that the adult AT1 cell population contains both Hopx+Igfbp2+ and Hopx+Igfbp2− AT1 cells, which have distinct cell fates during alveolar regeneration. Using an Igfbp2-CreER mouse model, we demonstrate that Hopx+Igfbp2+ AT1 cells represent terminally differentiated AT1 cells that are not able to transdifferentiate into AT2 cells during post-PNX alveolar regeneration. Our study provides tools and insights that will guide future investigations into the molecular and cellular mechanism or mechanisms underlying AT1 cell fate during lung development and regeneration.

scholarly journals Unbiased Quantitation of Alveolar Type II to Alveolar Type I Cell Transdifferentiation during Repair after Lung Injury in Mice

2017 ◽  
Vol 57 (5) ◽  
pp. 519-526 ◽  
Author(s):  
Nicole L. Jansing ◽  
Jazalle McClendon ◽  
Peter M. Henson ◽  
Rubin M. Tuder ◽  
Dallas M. Hyde ◽  
...  
Keyword(s):  
Lung Injury ◽  
Alveolar Type ◽  
Type I ◽  
Type Ii ◽  
Cell Transdifferentiation ◽  
Alveolar Type I Cell

scholarly journals The Rho Pathway Mediates Transition to an Alveolar Type I Cell Phenotype During Static Stretch of Alveolar Type II Cells

2010 ◽  
Vol 67 (6) ◽  
pp. 585-590 ◽  
Author(s):  
Cherie D Foster ◽  
Linda S Varghese ◽  
Linda W Gonzales ◽  
Susan S Margulies ◽  
Susan H Guttentag
Keyword(s):  
Cell Phenotype ◽  
Alveolar Type ◽  
Type I ◽  
Type Ii Cells ◽  
Type Ii ◽  
Alveolar Type Ii Cells ◽  
Static Stretch ◽  
Alveolar Type I Cell

scholarly journals Cloning, Characterization, and Developmental Expression of a Rat Lung Alveolar Type I Cell Gene in Embryonic Endodermal and Neural Derivatives

1995 ◽  
Vol 167 (1) ◽  
pp. 294-306 ◽  
Author(s):  
A.K. Rishi ◽  
M. Joyce-Brady ◽  
J. Fisher ◽  
L.G. Dobbs ◽  
J. Floros ◽  
...  
Keyword(s):  
Developmental Expression ◽  
Alveolar Type ◽  
Type I ◽  
Rat Lung ◽  
Cell Gene ◽  
Alveolar Type I Cell

scholarly journals A Novel Alveolar Type I Cell–Specific Biochemical Marker of Human Acute Lung Injury

2000 ◽  
Vol 161 (3) ◽  
pp. 990-995 ◽  
Author(s):  
VALERIE NEWMAN ◽  
ROBERT F. GONZALEZ ◽  
MICHAEL A. MATTHAY ◽  
LELAND G. DOBBS
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Biochemical Marker ◽  
Alveolar Type ◽  
Type I ◽  
Alveolar Type I Cell
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