scholarly journals RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability

Development ◽  
2017 ◽  
Vol 144 (24) ◽  
pp. 4658-4672 ◽  
Author(s):  
Melissa A. Borgen ◽  
Dandan Wang ◽  
Brock Grill
Keyword(s):  
Growth Cone ◽  
Growth Cone Collapse ◽  
Microtubule Stability ◽  
Axon Termination

scholarly journals Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections

2014 ◽  
Vol 7 (340) ◽  
pp. ra81-ra81 ◽  
Author(s):  
K.-Y. Wu ◽  
M. He ◽  
Q.-Q. Hou ◽  
A.-L. Sheng ◽  
L. Yuan ◽  
...  
Keyword(s):  
Growth Cone ◽  
Semaphorin 3A ◽  
Growth Cone Collapse ◽  
Guanosine Triphosphatase

scholarly journals Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Nicolas Unsain ◽  
Martin D. Bordenave ◽  
Gaby F. Martinez ◽  
Sami Jalil ◽  
Catalina von Bilderling ◽  
...  
Keyword(s):  
Growth Cone ◽  
Axonal Degeneration ◽  
Growth Cone Collapse

scholarly journals Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse

1997 ◽  
Vol 17 (16) ◽  
pp. 6256-6263 ◽  
Author(s):  
Zhao Jin ◽  
Stephen M. Strittmatter
Keyword(s):  
Growth Cone ◽  
Growth Cone Collapse

scholarly journals Growth cone collapse and inhibition of neurite growth by Botulinum neurotoxin C1: a t-SNARE is involved in axonal growth.

1996 ◽  
Vol 134 (1) ◽  
pp. 205-215 ◽  
Author(s):  
M Igarashi ◽  
S Kozaki ◽  
S Terakawa ◽  
S Kawano ◽  
C Ide ◽  
...  
Keyword(s):  
Growth Cone ◽  
Axonal Growth ◽  
Normal Growth ◽  
Neurite Growth ◽  
Total Surface Area ◽  
Central Domain ◽  
Growth Cone Collapse ◽  
Gradual Disappearance ◽  
Microscopic Studies ◽  
Presynaptic Protein

The growth cone is responsible for axonal growth, where membrane expansion is most likely to occur. Several recent reports have suggested that presynaptic proteins are involved in this process; however, the molecular mechanism details are unclear. We suggest that by cleaving a presynaptic protein syntaxin, which is essential in targeting synaptic vesicles as a target SNAP receptor (t-SNARE), neurotoxin C1 of Clostridium botulinum causes growth cone collapse and inhibits axonal growth. Video-enhanced microscopic studies showed (a) that neurotoxin C1 selectively blocked the activity of the central domain (the vesicle-rich region) at the initial stage, but not the lamellipodia in the growth cone; and (b) that large vacuole formation occurred probably through the fusion of smaller vesicles from the central domain to the most distal segments of the neurite. The total surface area of the accumulated vacuoles could explain the membrane expansion of normal neurite growth. The gradual disappearance of the surface labeling by FITC-WGA on the normal growth cone, suggesting membrane addition, was inhibited by neurotoxin C1. The experiments using the peptides derived from syntaxin, essential for interaction with VAMP or alpha-SNAP, supported the results using neurotoxin C1. Our results demonstrate that syntaxin is involved in axonal growth and indicate that syntaxin may participate directly in the membrane expansion that occurs in the central domain of the growth cone, probably through association with VAMP and SNAPs, in a SNARE-like way.

scholarly journals Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse

1995 ◽  
Vol 15 (11) ◽  
pp. 7158-7167 ◽  
Author(s):  
L Theodore ◽  
D Derossi ◽  
G Chassaing ◽  
B Llirbat ◽  
M Kubes ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Growth Cone ◽  
Growth Cone Collapse ◽  
Kinase C
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