scholarly journals Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation

Development ◽  
2017 ◽  
Vol 144 (10) ◽  
pp. 1798-1806 ◽  
Author(s):  
S. F. Gabriel Krens ◽  
Jim H. Veldhuis ◽  
Vanessa Barone ◽  
Daniel Čapek ◽  
Jean-Léon Maître ◽  
...  
Keyword(s):  
Surface Tension ◽  
Progenitor Cell ◽  
Interstitial Fluid ◽  
Tissue Surface ◽  
Tissue Surface Tension ◽  
Cell Segregation ◽  
Differential Tissue

scholarly journals Measuring accurately liquid and tissue surface tension with a compression plate tensiometer

HFSP Journal ◽  
2009 ◽  
Vol 3 (3) ◽  
pp. 213-221 ◽  
Author(s):  
Abbas Mgharbel ◽  
Hélène Delanoë‐Ayari ◽  
Jean‐Paul Rieu
Keyword(s):  
Surface Tension ◽  
Compression Plate ◽  
Tissue Surface ◽  
Tissue Surface Tension

scholarly journals Quantitative differences in tissue surface tension influence zebrafish germ layer positioning

HFSP Journal ◽  
2008 ◽  
Vol 2 (1) ◽  
pp. 42-56 ◽  
Author(s):  
Eva‐Maria Schötz ◽  
Rebecca D. Burdine ◽  
Frank Jülicher ◽  
Malcolm S. Steinberg ◽  
Carl‐Philipp Heisenberg ◽  
...  
Keyword(s):  
Surface Tension ◽  
Germ Layer ◽  
Tissue Surface ◽  
Tissue Surface Tension

scholarly journals Coaction of intercellular adhesion and cortical tension specifies tissue surface tension

2010 ◽  
Vol 107 (28) ◽  
pp. 12517-12522 ◽  
Author(s):  
M. Lisa Manning ◽  
Ramsey A. Foty ◽  
Malcolm S. Steinberg ◽  
Eva-Maria Schoetz
Keyword(s):  
Surface Tension ◽  
Intercellular Adhesion ◽  
Cortical Tension ◽  
Tissue Surface ◽  
Tissue Surface Tension

scholarly journals Can tissue surface tension drive somite formation?

2007 ◽  
Vol 307 (2) ◽  
pp. 248-257 ◽  
Author(s):  
Ramon Grima ◽  
Santiago Schnell
Keyword(s):  
Surface Tension ◽  
Tissue Surface ◽  
Somite Formation ◽  
Tissue Surface Tension

scholarly journals Tuning intercellular adhesion with membrane-anchored oligonucleotides

2019 ◽  
Vol 16 (159) ◽  
pp. 20190299
Author(s):  
Ian T. Hoffecker ◽  
Yusuke Arima ◽  
Hiroo Iwata
Keyword(s):  
Protein Expression ◽  
Force Feedback ◽  
Artificial Cell ◽  
Tissue Surface ◽  
Integral Role ◽  
Tissue Surface Tension ◽  
Adhesive Interactions ◽  
Cell Interface ◽  
Adhesion Control ◽  
Cell Cell

Adhesive interactions between cells play an integral role in development, differentiation and regeneration. Existing methods for controlling cell–cell cohesion and adhesion by manipulating protein expression are constrained by biological interdependencies, e.g. coupling of cadherins to actomyosin force-feedback mechanisms. We use oligonucleotides conjugated to PEGylated lipid anchors (ssDNAPEGDPPE) to introduce artificial cell–cell adhesion that is largely decoupled from the internal cytoskeleton. We describe cell–cell doublets with a mechanical model based on isotropic, elastic deformation of spheres to estimate the adhesion at the cell–cell interface. Physical manipulation of adhesion by modulating the PEG-lipid to ssDNAPEGDPPE ratio, and conversely treating with actin-depolymerizing cytochalasin D, resulted in decreases and increases in doublet contact area, respectively. Our data are relevant to the ongoing discussion over mechanisms of tissue surface tension and in agreement with models based on opposing cortical and cohesive forces. PEG-lipid modulation of doublet geometries resulted in a well-defined curve indicating continuity, enabling prescriptive calibration for controlling doublet geometry. Our study demonstrates tuning of basic doublet adhesion, laying the foundation for more complex multicellular adhesion control independent of protein expression.

Sign in / Sign up

Export Citation Format

Share Document