scholarly journals Functional antagonism of voltage-gated K+channel α-subunits in the developing brain ventricular system

Development ◽  
2016 ◽  
Vol 143 (22) ◽  
pp. 4249-4260 ◽  
Author(s):  
Hongyuan Shen ◽  
Elke Bocksteins ◽  
Igor Kondrychyn ◽  
Dirk Snyders ◽  
Vladimir Korzh
Keyword(s):  
Ventricular System ◽  
Developing Brain ◽  
K Channel ◽  
Voltage Gated ◽  
Functional Antagonism ◽  
Brain Ventricular System ◽  
Α Subunits

Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel β-subunit

2002 ◽  
Vol 283 (1) ◽  
pp. F142-F149 ◽  
Author(s):  
Shulan Tian ◽  
Weimin Liu ◽  
Yanling Wu ◽  
Hamid Rafi ◽  
Alan S. Segal ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
K Channel ◽  
Kinetic Properties ◽  
Functional Assay ◽  
Accessory Proteins ◽  
Amino Acid Homology ◽  
Α Subunit ◽  
Voltage Gated ◽  
Kv Channels ◽  
Α Subunits

Voltage-gated K+ (Kv) channels are heteromultimeric complexes consisting of pore-forming α-subunits and accessory β-subunits. Several β-subunits have been identified and shown to interact with specific α-subunits to modify their levels of expression or some of their kinetic properties. The aim of the present study was to isolate accessory proteins for KCNA10, a novel Kv channel α-subunit functionally related to Kv and cyclic nucleotide-gated cation channels. Because one distinguishing feature of KCNA10 is a putative cyclic nucleotide-binding domain located at the COOH terminus, the entire COOH-terminal region was used to probe a human cardiac cDNA library using the yeast two-hybrid system. Interacting clones were then rescreened in a functional assay by coinjection with KCNA10 in Xenopus oocytes. One of these clones (KCNA4B), when injected alone in oocytes, produced no detectable current. However, when coinjected with KCNA10, it increased KCNA10 current expression by nearly threefold. In addition, the current became more sensitive to activation by cAMP. KCNA4B can be coimmunoprecipitated with the COOH terminus of KCNA10 and full-length KCNA10. It encodes a soluble protein (141 aa) with no amino acid homology to known β-subunits but with limited structural similarity to the NAD(P)H-dependent oxidoreductase superfamily. KCNA4Bis located on chromosome 13 and spans ∼16 kb, and its coding region is made up of five exons. In conclusion, KCNA4B represents the first member of a new class of accessory proteins that modify the properties of Kv channels.

Structural Influence of Hanatoxin Binding on the Carboxyl Terminus of S3 Segment in Voltage-Gated K + -Channel Kv2.1

2002 ◽  
Vol 8 (2) ◽  
pp. 79-85 ◽  
Author(s):  
P. T. Huang ◽  
T. Y. Chen ◽  
L. J. Tseng ◽  
K. L. Lou ◽  
H. H. Liou ◽  
...  
Keyword(s):  
Carboxyl Terminus ◽  
K Channel ◽  
Voltage Gated ◽  
S3 Segment ◽  
Structural Influence

TNF-α inhibits the CD3-mediated upregulation of voltage-gated K+ channel (Kv1.3) in human T cells

2010 ◽  
Vol 391 (1) ◽  
pp. 909-914 ◽  
Author(s):  
Bo Pang ◽  
Haifeng Zheng ◽  
Dong Hoon Shin ◽  
Kyeong Cheon Jung ◽  
Jae Hong Ko ◽  
...  
Keyword(s):  
T Cells ◽  
K Channel ◽  
Voltage Gated ◽  
Human T Cells ◽  
Tnf Α

scholarly journals The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen

Platelets ◽  
2021 ◽  
pp. 1-11
Author(s):  
Joy R Wright ◽  
Sarah Jones ◽  
Sasikumar Parvathy ◽  
Leonard K Kaczmarek ◽  
Ian Forsythe ◽  
...  
Keyword(s):  
K Channel ◽  
Voltage Gated ◽  
Α2β1 Integrin

scholarly journals Complex distribution patterns of voltage-gated calcium channel α-subunits in the spiral ganglion

2011 ◽  
Vol 278 (1-2) ◽  
pp. 52-68 ◽  
Author(s):  
Wei Chun Chen ◽  
Hui Zhong Xue ◽  
Yun (Lucy) Hsu ◽  
Qing Liu ◽  
Shail Patel ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Spiral Ganglion ◽  
Distribution Patterns ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Α Subunits ◽  
Complex Distribution

Hanging Gondola Structure of the T1 Domain in a Voltage-Gated K+Channel†

Biochemistry ◽  
2000 ◽  
Vol 39 (34) ◽  
pp. 10347-10352 ◽  
Author(s):  
William R. Kobertz ◽  
Carole Williams ◽  
Christopher Miller
Keyword(s):  
K Channel ◽  
Voltage Gated ◽  
T1 Domain

scholarly journals Regulation of the Voltage Gated K+Channel Kv1.3by Recombinant Human Klotho Protein

2014 ◽  
Vol 39 (6) ◽  
pp. 609-622 ◽  
Author(s):  
Ahmad Almilaji ◽  
Sabina Honisch ◽  
Guilai Liu ◽  
Bernat Elvira ◽  
Sumant Singh Ajay ◽  
...  
Keyword(s):  
K Channel ◽  
Voltage Gated ◽  
Klotho Protein
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