scholarly journals Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

Development ◽  
2016 ◽  
Vol 143 (17) ◽  
pp. 3050-3060 ◽  
Author(s):  
Jason S. L. Yu ◽  
Wei Cui
Keyword(s):  
Cell Fate ◽  
Cell Fate Determination ◽  
Fate Determination ◽  
Mtor Signalling

scholarly journals Jagged–Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype

2015 ◽  
Vol 112 (5) ◽  
pp. E402-E409 ◽  
Author(s):  
Marcelo Boareto ◽  
Mohit Kumar Jolly ◽  
Mingyang Lu ◽  
José N. Onuchic ◽  
Cecilia Clementi ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Target Genes ◽  
Tumor Stroma ◽  
Notch Receptor ◽  
Toggle Switch ◽  
Cell Fate Determination ◽  
Asymmetric Effect ◽  
Fate Determination

Notch signaling pathway mediates cell-fate determination during embryonic development, wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the ligand Jagged of one cell interacts with the Notch receptor of its neighboring cell, releasing the Notch Intracellular Domain (NICD) that activates many downstream target genes. NICD affects ligand production asymmetrically––it represses Delta, but activates Jagged. Although the dynamical role of Notch–Jagged signaling remains elusive, it is widely recognized that Notch–Delta signaling behaves as an intercellular toggle switch, giving rise to two distinct fates that neighboring cells adopt––Sender (high ligand, low receptor) and Receiver (low ligand, high receptor). Here, we devise a specific theoretical framework that incorporates both Delta and Jagged in Notch signaling circuit to explore the functional role of Jagged in cell-fate determination. We find that the asymmetric effect of NICD renders the circuit to behave as a three-way switch, giving rise to an additional state––a hybrid Sender/Receiver (medium ligand, medium receptor). This phenotype allows neighboring cells to both send and receive signals, thereby attaining similar fates. We also show that due to the asymmetric effect of the glycosyltransferase Fringe, different outcomes are generated depending on which ligand is dominant: Delta-mediated signaling drives neighboring cells to have an opposite fate; Jagged-mediated signaling drives the cell to maintain a similar fate to that of its neighbor. We elucidate the role of Jagged in cell-fate determination and discuss its possible implications in understanding tumor–stroma cross-talk, which frequently entails Notch–Jagged communication.

Dominant role of the niche in melanocyte stem-cell fate determination

Nature ◽  
2002 ◽  
Vol 416 (6883) ◽  
pp. 854-860 ◽  
Author(s):  
Emi K. Nishimura ◽  
Siobhán A. Jordan ◽  
Hideo Oshima ◽  
Hisahiro Yoshida ◽  
Masatake Osawa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Dominant Role ◽  
Cell Fate Determination ◽  
Stem Cell Fate ◽  
Fate Determination ◽  
Melanocyte Stem Cell

Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs)

2016 ◽  
Vol 104 (3) ◽  
pp. 324-329 ◽  
Author(s):  
Shin’ichiro Yasunaga ◽  
Yoshinori Ohno ◽  
Naoto Shirasu ◽  
Bo Zhang ◽  
Kyoko Suzuki-Takedachi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Cell Fate ◽  
Cell Fate Determination ◽  
Hematopoietic Stem ◽  
Fate Determination

Role of extracellular matrix and YAP/TAZ in cell fate determination

2014 ◽  
Vol 26 (2) ◽  
pp. 186-191 ◽  
Author(s):  
Jin Hao ◽  
Yueling Zhang ◽  
Yating Wang ◽  
Rui Ye ◽  
Jingyi Qiu ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Fate ◽  
Cell Fate Determination ◽  
Fate Determination

scholarly journals Role of miRNAs and epigenetics in neural stem cell fate determination

Epigenetics ◽  
2013 ◽  
Vol 9 (1) ◽  
pp. 90-100 ◽  
Author(s):  
Miguel Alejandro Lopez-Ramirez ◽  
Stefania Nicoli
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Cell Fate Determination ◽  
Stem Cell Fate ◽  
Fate Determination
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