scholarly journals The EGFR signaling pathway controls gut progenitor differentiation during planarian regeneration and homeostasis

Development ◽  
2016 ◽  
Vol 143 (12) ◽  
pp. 2089-2102 ◽  
Author(s):  
Sara Barberán ◽  
Susanna Fraguas ◽  
Francesc Cebrià
Keyword(s):  
Signaling Pathway ◽  
Egfr Signaling ◽  
Planarian Regeneration ◽  
Egfr Signaling Pathway

scholarly journals Reactive oxygen species rescue regeneration after silencing the MAPK–ERK signaling pathway in Schmidtea mediterranea

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
V. Jaenen ◽  
S. Fraguas ◽  
K. Bijnens ◽  
M. Heleven ◽  
T. Artois ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Signaling Pathway ◽  
Reactive Oxygen ◽  
Light Therapy ◽  
Erk Signaling ◽  
Model Organisms ◽  
Ros Production ◽  
Oxygen Species ◽  
Planarian Regeneration ◽  
Egfr Signaling Pathway

AbstractDespite extensive research on molecular pathways controlling the process of regeneration in model organisms, little is known about the actual initiation signals necessary to induce regeneration. Recently, the activation of ERK signaling has been shown to be required to initiate regeneration in planarians. However, how ERK signaling is activated remains unknown. Reactive Oxygen Species (ROS) are well-known early signals necessary for regeneration in several models, including planarians. Still, the probable interplay between ROS and MAPK/ERK has not yet been described. Here, by interfering with major mediators (ROS, EGFR and MAPK/ERK), we were able to identify wound-induced ROS, and specifically H2O2, as upstream cues in the activation of regeneration. Our data demonstrate new relationships between regeneration-related ROS production and MAPK/ERK activation at the earliest regeneration stages, as well as the involvement of the EGFR-signaling pathway. Our results suggest that (1) ROS and/or H2O2 have the potential to rescue regeneration after MEK-inhibition, either by H2O2-treatment or light therapy, (2) ROS and/or H2O2 are required for the activation of MAPK/ERK signaling pathway, (3) the EGFR pathway can mediate ROS production and the activation of MAPK/ERK during planarian regeneration.

scholarly journals β1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells

Oncotarget ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 3673-3684 ◽  
Author(s):  
Mei-Ieng Che ◽  
John Huang ◽  
Ji-Shiang Hung ◽  
Yo-Chuen Lin ◽  
Miao-Juei Huang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colon Cancer Cells ◽  
Egfr Signaling ◽  
Cancer Stemness ◽  
Egfr Signaling Pathway

Tu1606 Galectin-3 Regulates Gastric Cancer Cell Proliferation Through EGFR Signaling Pathway.

2013 ◽  
Vol 144 (5) ◽  
pp. S-804
Author(s):  
Nobuko Serizawa ◽  
Akihito Nagahara ◽  
Shunhei Yamashina ◽  
Gentaro Taniguchi ◽  
Sumio Watanabe
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Egfr Signaling ◽  
Egfr Signaling Pathway ◽  
Galectin 3 ◽  
Gastric Cancer Cell Proliferation

scholarly journals miR-20b reduces 5-FU resistance by suppressing the ADAM9/EGFR signaling pathway in colon cancer

2016 ◽  
Vol 37 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Qiang Fu ◽  
Jing Cheng ◽  
Jindai Zhang ◽  
Yonglei Zhang ◽  
Xiaobing Chen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Signaling Pathway ◽  
Egfr Signaling ◽  
Egfr Signaling Pathway

Interaction of the EGFR signaling pathway with porcine cumulus oocyte complexes and oviduct cells in a coculture system

2018 ◽  
Vol 234 (4) ◽  
pp. 4030-4043 ◽  
Author(s):  
Seok Hee Lee ◽  
Hyun Ju Oh ◽  
Min Jung Kim ◽  
Erif maha Nugraha Setyawan ◽  
Byeong Chun Lee
Keyword(s):  
Signaling Pathway ◽  
Egfr Signaling ◽  
Egfr Signaling Pathway ◽  
Coculture System
Sign in / Sign up

Export Citation Format

Share Document