The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila

Development ◽  
2001 ◽  
Vol 128 (22) ◽  
pp. 4545-4552 ◽  
Author(s):  
G. C. Teg Pipes ◽  
Qing Lin ◽  
Stephanie E. Riley ◽  
Corey S. Goodman
Keyword(s):  
Axon Guidance ◽  
Specific Growth ◽  
Growth Cones ◽  
Beat Generation ◽  
Genetic Screen ◽  
Genetic Interactions ◽  
Membrane Bound ◽  
Adhesive Factor ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

A previous genetic screen led to the identification of the beaten path (beat Ia) gene in Drosophila. Beat Ia contains two immunoglobulin (Ig) domains and appears to function as an anti-adhesive factor secreted by specific growth cones to promote axon defasciculation. We identify a family of 14 beat-like genes in Drosophila. In contrast to beat Ia, four novel Beat-family genes encode membrane-bound proteins. Moreover, mutations in each gene lead to much more subtle guidance phenotypes than observed in beat Ia. Genetic interactions between beat Ic and beat Ia reveal complementary functions. Our data suggest a model whereby Beat Ic (and perhaps other membrane-bound family members) functions in a pro-adhesive fashion to regulate fasciculation, while Beat Ia (the original secreted Beat) functions in an anti-adhesive fashion to regulate defasciculation.

scholarly journals Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Kentarou Baba ◽  
Wataru Yoshida ◽  
Michinori Toriyama ◽  
Tadayuki Shimada ◽  
Colleen F Manning ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Axon Guidance ◽  
Cell Adhesion Molecule ◽  
Growth Cones ◽  
Spatial Cues ◽  
Commissural Axons ◽  
Guidance Cues ◽  
Cell Adhesion Molecule L1 ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

Growth cones navigate axonal projection in response to guidance cues. However, it is unclear how they can decide the migratory direction by transducing the local spatial cues into protrusive forces. Here we show that knockout mice of Shootin1 display abnormal projection of the forebrain commissural axons, a phenotype similar to that of the axon guidance molecule netrin-1. Shallow gradients of netrin-1 elicited highly polarized Pak1-mediated phosphorylation of shootin1 within growth cones. We demonstrate that netrin-1–elicited shootin1 phosphorylation increases shootin1 interaction with the cell adhesion molecule L1-CAM; this, in turn, promotes F-actin–adhesion coupling and concomitant generation of forces for growth cone migration. Moreover, the spatially regulated shootin1 phosphorylation within growth cones is required for axon turning induced by netrin-1 gradients. Our study defines a mechano-effector for netrin-1 signaling and demonstrates that shootin1 phosphorylation is a critical readout for netrin-1 gradients that results in a directional mechanoresponse for axon guidance.

LOTUS, a novel axon guidance molecule, functions as a negative regulator of Nogo signaling in LOT formation

2009 ◽  
Vol 65 ◽  
pp. S94
Author(s):  
Masumi Iketani ◽  
Megumi Yamaguchi ◽  
Yuko Arie ◽  
Yuji Kurihara ◽  
Yasufumi Sato ◽  
...  
Keyword(s):  
Axon Guidance ◽  
Negative Regulator ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

Abstract 3574: Novel roles of an axon-guidance molecule, semaphorin 3E, in pancreatic cancer

2015 ◽  
Author(s):  
Lin-Kin Yong ◽  
Dali Li ◽  
Ethan Poteet ◽  
Zhengdong Liang ◽  
William Fisher ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Axon Guidance ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

Phenotype of V2-derived interneurons and their relationship to the axon guidance molecule EphA4 in the developing mouse spinal cord

2007 ◽  
Vol 26 (11) ◽  
pp. 2989-3002 ◽  
Author(s):  
Line Lundfald ◽  
C. Ernesto Restrepo ◽  
Simon J. B. Butt ◽  
Chian-Yu Peng ◽  
Steven Droho ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Axon Guidance ◽  
Mouse Spinal Cord ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

Promotion of neurite outgrowth by a novel axon guidance molecule LOTUS

2009 ◽  
Vol 65 ◽  
pp. S94
Author(s):  
Yuji Kurihara ◽  
Yuko Arie ◽  
Megumi Yamaguchi ◽  
Masumi Iketani ◽  
Fumio Nakamura ◽  
...  
Keyword(s):  
Axon Guidance ◽  
Neurite Outgrowth ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

Structural and functional analysis of the axon guidance molecule Sema3A and its receptor

2004 ◽  
Vol 2004 (Fall) ◽  
Author(s):  
Claudia Hoemme ◽  
Jens Schwamborn ◽  
Alexander Antipenko ◽  
Dimitar B. Nikolov ◽  
Andreas W. P�schel
Keyword(s):  
Functional Analysis ◽  
Axon Guidance ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

LOTUS, a novel axon guidance molecule

2009 ◽  
Vol 65 ◽  
pp. S94
Author(s):  
Yasufumi Sato ◽  
Megumi Yamaguchi ◽  
Masumi Iketani ◽  
Yuko Arie ◽  
Yuji Kurihara ◽  
...  
Keyword(s):  
Axon Guidance ◽  
Axon Guidance Molecule ◽  
Guidance Molecule
Sign in / Sign up

Export Citation Format

Share Document