scholarly journals Novel guidance cues during neuronal pathfinding in the early scaffold of axon tracts in the rostral brain

Development ◽  
1999 ◽  
Vol 126 (9) ◽  
pp. 1859-1868
Author(s):  
R.B. Anderson ◽  
B. Key
Keyword(s):  
Axon Guidance ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Soluble Carbohydrates ◽  
Vertebrate Brain ◽  
Cell Surface Carbohydrate ◽  
Neural Cell Adhesion ◽  
A Cell ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

A scaffold of axons consisting of a pair of longitudinal tracts and several commissures is established during early development of the vertebrate brain. We report here that NOC-2, a cell surface carbohydrate, is selectively expressed by a subpopulation of growing axons in this scaffold in Xenopus. NOC-2 is present on two glycoproteins, one of which is a novel glycoform of the neural cell adhesion molecule N-CAM. When the function of NOC-2 was perturbed using either soluble carbohydrates or anti-NOC-2 antibodies, axons expressing NOC-2 exhibited aberrant growth at specific points in their pathway. NOC-2 is the first-identified axon guidance molecule essential for development of the axon scaffold in the embryonic vertebrate brain.

scholarly journals Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1

1998 ◽  
Vol 8 (1) ◽  
pp. 26-33 ◽  
Author(s):  
N.R. Cohen ◽  
J.S.H. Taylor ◽  
L.B. Scott ◽  
R.W. Guillery ◽  
P. Soriano ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Axon Guidance ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Neural Cell Adhesion ◽  
Cell Adhesion Molecule L1

scholarly journals Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Kentarou Baba ◽  
Wataru Yoshida ◽  
Michinori Toriyama ◽  
Tadayuki Shimada ◽  
Colleen F Manning ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Axon Guidance ◽  
Cell Adhesion Molecule ◽  
Growth Cones ◽  
Spatial Cues ◽  
Commissural Axons ◽  
Guidance Cues ◽  
Cell Adhesion Molecule L1 ◽  
Axon Guidance Molecule ◽  
Guidance Molecule

Growth cones navigate axonal projection in response to guidance cues. However, it is unclear how they can decide the migratory direction by transducing the local spatial cues into protrusive forces. Here we show that knockout mice of Shootin1 display abnormal projection of the forebrain commissural axons, a phenotype similar to that of the axon guidance molecule netrin-1. Shallow gradients of netrin-1 elicited highly polarized Pak1-mediated phosphorylation of shootin1 within growth cones. We demonstrate that netrin-1–elicited shootin1 phosphorylation increases shootin1 interaction with the cell adhesion molecule L1-CAM; this, in turn, promotes F-actin–adhesion coupling and concomitant generation of forces for growth cone migration. Moreover, the spatially regulated shootin1 phosphorylation within growth cones is required for axon turning induced by netrin-1 gradients. Our study defines a mechano-effector for netrin-1 signaling and demonstrates that shootin1 phosphorylation is a critical readout for netrin-1 gradients that results in a directional mechanoresponse for axon guidance.

BOC, brother of CDO, is a dorsoventral axon-guidance molecule in the embryonic vertebrate brain

2005 ◽  
Vol 485 (1) ◽  
pp. 32-42 ◽  
Author(s):  
Robin M. Connor ◽  
Chelsea L. Allen ◽  
Christine A. Devine ◽  
Christina Claxton ◽  
Brian Key
Keyword(s):  
Axon Guidance ◽  
Vertebrate Brain ◽  
Axon Guidance Molecule ◽  
Guidance Molecule
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