The development and evolution of bristle patterns in Diptera

Development ◽  
1999 ◽  
Vol 126 (7) ◽  
pp. 1349-1364 ◽  
Author(s):  
P. Simpson ◽  
R. Woehl ◽  
K. Usui
Keyword(s):  
Gene Expression ◽  
Spatial Distribution ◽  
Life Cycle ◽  
Genetic Regulation ◽  
Growth Period ◽  
Genetic Pathways ◽  
Current State ◽  
Bristle Patterns ◽  
Bristle Pattern ◽  
Development And Evolution

The spatial distribution of sensory bristles on the notum of different species of Diptera is compared. Species displaying ancestral features have a simple organization of randomly distributed, but uniformly spaced, bristles, whereas species thought to be more derived bear patterns in which the bristles are aligned into longitudinal rows. The number of rows of large bristles on the scutum was probably restricted to four early on in the evolution of cyclorraphous Brachyceran flies. Most species have stereotyped patterns based on modifications of these four rows. The possible constraints placed upon the patterning mechanisms due to growth and moulting within the Diptera are discussed, as well as within hemimetabolous insects. The holometabolic life cycle and the setting aside of groups of imaginal cells whose function is not required during the growth period, may have provided the freedom necessary for the evolution of elaborate bristle patterns. We briefly review the current state of knowledge concerning the complex genetic pathways regulating achaete-scute gene expression and bristle pattern in Drosophila melanogaster, and consider mechanisms for the genetic regulation of the bristle patterns of other species of Diptera.

Modeling spatial distribution of the unionid mussels and the core-satellite hypothesis

1998 ◽  
Vol 38 (7) ◽  
pp. 73-79 ◽  
Author(s):  
Hooi-Ling Lee ◽  
Donald DeAngelis ◽  
Hock-Lye Koh
Keyword(s):  
Spatial Distribution ◽  
Life Cycle ◽  
Success Rate ◽  
Distribution Patterns ◽  
Fish Host ◽  
Limited Movement ◽  
Unionid Mussels ◽  
Species Characteristics ◽  
Major Factors ◽  
Fish Hosts

This paper discusses the spatial distribution patterns of the various species of the Unionid mussels as functions of their respective life-cycle characteristics. Computer simulations identify two life-cycle characteristics as major factors governing the abundance of a species, namely the movement range of their fish hosts and the success rate of the parasitic larval glochidia in finding fish hosts. Core mussels species have fish hosts with large movement range to disperse the parasitic larval glochidia to achieve high levels of abundance. Species associated with fish host of limited movement range require high success rate of finding fish host to achieve at least an intermediate level of abundance. Species with low success rate of finding fish hosts coupled with fish hosts having limited movement range exhibit satellite species characteristics, namely rare in numbers and sparse in distributions.

Life cycle assessment of carbon capture and storage/utilization: From current state to future research directions and opportunities

2021 ◽  
Vol 108 ◽  
pp. 103309
Author(s):  
Tatiane Tobias da Cruz ◽  
José A. Perrella Balestieri ◽  
João M. de Toledo Silva ◽  
Mateus R.N. Vilanova ◽  
Otávio J. Oliveira ◽  
...  
Keyword(s):  
Life Cycle Assessment ◽  
Life Cycle ◽  
Carbon Capture ◽  
Carbon Capture And Storage ◽  
Future Research ◽  
Research Directions ◽  
Current State ◽  
Future Research Directions ◽  
And Storage

scholarly journals Long non-coding RNAs in brain tumors

NAR Cancer ◽  
2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Keisuke Katsushima ◽  
George Jallo ◽  
Charles G Eberhart ◽  
Ranjan J Perera
Keyword(s):  
Gene Expression ◽  
Brain Tumors ◽  
Brain Cancer ◽  
Regulation Of Gene Expression ◽  
Therapeutic Targets ◽  
Diagnostic Biomarkers ◽  
Cancer Pathogenesis ◽  
Current State ◽  
Non Coding Rnas ◽  
Post Transcriptional Regulation

Abstract Long non-coding RNAs (lncRNAs) have been found to be central players in the epigenetic, transcriptional and post-transcriptional regulation of gene expression. There is an accumulation of evidence on newly discovered lncRNAs, their molecular interactions and their roles in the development and progression of human brain tumors. LncRNAs can have either tumor suppressive or oncogenic functions in different brain cancers, making them attractive therapeutic targets and biomarkers for personalized therapy and precision diagnostics. Here, we summarize the current state of knowledge of the lncRNAs that have been implicated in brain cancer pathogenesis, particularly in gliomas and medulloblastomas. We discuss their epigenetic regulation as well as the prospects of using lncRNAs as diagnostic biomarkers and therapeutic targets in patients with brain tumors.

scholarly journals Species diversity and spatial distribution of CL/VL vectors: assessing bioclimatic effect on expression plasticity of genes possessing vaccine properties isolated from wild-collected sand flies in endemic areas of Iran

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali Bordbar ◽  
Parviz Parvizi
Keyword(s):  
Gene Expression ◽  
Spatial Distribution ◽  
Interpolation Method ◽  
Diversity Index ◽  
Fold Change ◽  
Control Measures ◽  
Pcr Analysis ◽  
Physiological Status ◽  
Sand Flies ◽  
Risk Maps

Abstract Background Leishmaniasis is one of the ten most important neglected tropical diseases worldwide. Understanding the distribution of vectors of visceral and cutaneous leishmaniasis (VL/CL) is one of the significant strategic frameworks to control leishmaniasis. In this study, the extent of the bioclimatic variability was investigated to recognize a rigorous cartographic of the spatial distribution of VL/CL vectors as risk-maps using ArcGIS modeling system. Moreover, the effect of bioclimatic diversity on the fold change expression of genes possessing vaccine traits (SP15 and LeIF) was evaluated in each bioclimatic region using real-time PCR analysis. Methods The Inverse Distance Weighting interpolation method was used to obtain accurate geography map in closely-related distances. Bioclimatic indices were computed and vectors spatial distribution was analyzed in ArcGIS10.3.1 system. Species biodiversity was calculated based on Shannon diversity index using Rv.3.5.3. Expression fold change of SP15 and LeIF genes was evaluated using cDNA synthesis and RT-qPCR analysis. Results Frequency of Phlebotomus papatasi was predominant in plains areas of Mountainous bioclimate covering the CL hot spots. Mediterranean region was recognized as an important bioclimate harboring prevalent patterns of VL vectors. Semi-arid bioclimate was identified as a major contributing factor to up-regulate salivary-SP15 gene expression (P = 0.0050, P < 0.05). Also, Mediterranean bioclimate had considerable effect on up-regulation of Leishmania-LeIF gene in gravid and semi-gravid P. papatasi population (P = 0.0109, P < 0.05). Conclusions The diversity and spatial distribution of CL/VL vectors associated with bioclimatic regionalization obtained in our research provide epidemiological risk maps and establish more effectively control measures against leishmaniasis. Oscillations in gene expression indicate that each gene has its own features, which are profoundly affected by bioclimatic characteristics and physiological status of sand flies. Given the efficacy of species-specific antigens for vaccine production, it is essential to consider bioclimatic factors that have a fundamental role in affecting the regulatory regions of environmentally responsive loci for genes used in vaccine design.

Future trends in diagnosis using laboratory-on-a-chip technologies

Parasitology ◽  
1999 ◽  
Vol 117 (7) ◽  
pp. 191-203 ◽  
Author(s):  
M. S. TALARY ◽  
J. P. H. BURT ◽  
R. PETHIG
Keyword(s):  
Gene Expression ◽  
Lower Cost ◽  
Building Blocks ◽  
Cancer Diagnostics ◽  
Future Trends ◽  
Biotechnological Applications ◽  
Environmental Testing ◽  
Current State ◽  
Microelectronic Fabrication ◽  
Wide Range

There has been an enormous growth in the development of biotechnological applications, where advances in the techniques of microelectronic fabrication and the technologies of miniaturization and integration in semiconductor industries are being applied to the production of Laboratory-on-a-Chip devices. The aim of this development is to create devices that will perform the same processes that are currently carried out in the laboratory in reduced timescales, at a lower cost, requiring less reagents, and with a greater resolution of detection and specificity. The expectations of this Laboratory-on-a-Chip revolution is that this technology will facilitate rapid advances in gene discovery, genetic mapping and gene expression with broader applications ranging from infectious diseases and cancer diagnostics to food quality and environmental testing. A review of the current state of development in this field reveals the scale of the ongoing revolution and serves to highlight the advances that can be perceived in the development of Laboratory-on-a-Chip technologies. Since miniaturization can be applied to such a wide range of laboratory processes, some of the sub-units that can be used as building blocks in these devices are described, with a brief description of some of the fabrication processes that can be used to create them.

scholarly journals Dynamics of Wolbachia pipientis Gene Expression Across the Drosophila melanogaster Life Cycle

2015 ◽  
Vol 5 (12) ◽  
pp. 2843-2856 ◽  
Author(s):  
Florence Gutzwiller ◽  
Catarina R. Carmo ◽  
Danny E. Miller ◽  
Danny W. Rice ◽  
Irene L. G. Newton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Life Cycle ◽  
Wolbachia Pipientis
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