scholarly journals Notch signaling functions in lymphatic valve formation

Development ◽  
2014 ◽  
Vol 141 (12) ◽  
pp. 2446-2451 ◽  
Author(s):  
A. Murtomaki ◽  
M. K. Uh ◽  
C. Kitajewski ◽  
J. Zhao ◽  
T. Nagasaki ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Lymphatic Valve ◽  
Valve Formation

scholarly journals Integrin Alpha-9 Mediates Lymphatic Valve Formation in Corneal Lymphangiogenesis

2015 ◽  
Vol 56 (11) ◽  
pp. 6313 ◽  
Author(s):  
Eda Altiok ◽  
Tatiana Ecoiffier ◽  
Roberto Sessa ◽  
Don Yuen ◽  
Sammy Grimaldo ◽  
...  
Keyword(s):  
Lymphatic Valve ◽  
Corneal Lymphangiogenesis ◽  
Valve Formation

scholarly journals Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function

2014 ◽  
Vol 7 (347) ◽  
pp. ra97-ra97 ◽  
Author(s):  
X. Liu ◽  
S. Pasula ◽  
H. Song ◽  
K. L. Tessneer ◽  
Y. Dong ◽  
...  
Keyword(s):  
Spatial Regulation ◽  
Lymphatic Valve ◽  
Temporal And Spatial ◽  
And Function ◽  
Valve Formation

scholarly journals The Ebb and Flow of Lymphatic Valve Formation

2012 ◽  
Vol 22 (2) ◽  
pp. 242-243 ◽  
Author(s):  
Ryan S. Udan ◽  
Mary E. Dickinson
Keyword(s):  
Lymphatic Valve ◽  
Valve Formation ◽  
Ebb And Flow

scholarly journals Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Anne-Laure Duchemin ◽  
Hélène Vignes ◽  
Julien Vermot
Keyword(s):  
Notch Signaling ◽  
Heart Valve ◽  
Notch Signaling Pathway ◽  
Outflow Tract ◽  
Mechanical Forces ◽  
Valve Development ◽  
Signaling Axis ◽  
Cell Layers ◽  
Valve Formation

Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layers. Furthermore, we show that Piezo and TRP mechanosensitive channels are important factors modulating these pathways. In addition, live reporters reveal that Piezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle progenitors to coordinate OFT valve morphogenesis. Together, this work identifies a unique morphogenetic program during OFT valve formation and places Piezo as a central modulator of the cell response to forces in this process.

scholarly journals FOXO1 represses lymphatic valve formation and maintenance via PRDM1

Cell Reports ◽  
2021 ◽  
Vol 37 (9) ◽  
pp. 110048
Author(s):  
Kenta Niimi ◽  
Jun Nakae ◽  
Shinobu Inagaki ◽  
Tatsuo Furuyama
Keyword(s):  
Lymphatic Valve ◽  
Valve Formation

scholarly journals Corneal Lymphatic Valve Formation in Relation to Lymphangiogenesis

2014 ◽  
Vol 55 (3) ◽  
pp. 1876 ◽  
Author(s):  
Tan Truong ◽  
Eric Huang ◽  
Don Yuen ◽  
Lu Chen
Keyword(s):  
Lymphatic Valve ◽  
Valve Formation

scholarly journals Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

Blood ◽  
2013 ◽  
Vol 122 (4) ◽  
pp. 598-607 ◽  
Author(s):  
Sandrine Levet ◽  
Delphine Ciais ◽  
Galina Merdzhanova ◽  
Christine Mallet ◽  
Teresa A. Zimmers ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Lymphatic Vessel ◽  
Morphogenetic Protein ◽  
Key Points ◽  
Lymphatic Valve ◽  
Bone Morphogenetic Protein 9 ◽  
Vessel Maturation ◽  
Valve Formation

Key Points BMP9 is required for lymphatic valve formation. Mice deficient in Bmp9 exhibit reduction in lymphatic draining efficiency.

scholarly journals Mechanically activated Piezo channels control outflow tract valve development through Yap1 and Klf2-Notch signaling axis

2019 ◽  
Author(s):  
Anne Laure Duchemin ◽  
Hélène Vignes ◽  
Julien Vermot
Keyword(s):  
Notch Signaling ◽  
Heart Valve ◽  
Notch Signaling Pathway ◽  
Outflow Tract ◽  
Mechanical Forces ◽  
Valve Development ◽  
Signaling Axis ◽  
Cell Layers ◽  
Valve Formation

AbstractMechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layers. Furthermore, we show that Piezo and TRP mechanosensitive channels are essential for regulating these pathways. In addition, live reporters reveal that piezo controls Klf2 and Notch activity in the endothelium and Yap1 expression in the smooth muscle progenitors to coordinate OFT valve morphogenesis. Together, this work identifies a unique morphogenetic program during OFT valve formation and places Piezo as a central modulator of the cell response to forces in this process.

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